全文获取类型
收费全文 | 7042篇 |
免费 | 297篇 |
国内免费 | 58篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 135篇 |
妇产科学 | 57篇 |
基础医学 | 859篇 |
口腔科学 | 106篇 |
临床医学 | 473篇 |
内科学 | 1947篇 |
皮肤病学 | 66篇 |
神经病学 | 432篇 |
特种医学 | 344篇 |
外科学 | 1036篇 |
综合类 | 58篇 |
一般理论 | 2篇 |
预防医学 | 199篇 |
眼科学 | 203篇 |
药学 | 372篇 |
中国医学 | 11篇 |
肿瘤学 | 1074篇 |
出版年
2023年 | 46篇 |
2022年 | 93篇 |
2021年 | 155篇 |
2020年 | 88篇 |
2019年 | 121篇 |
2018年 | 138篇 |
2017年 | 110篇 |
2016年 | 158篇 |
2015年 | 146篇 |
2014年 | 231篇 |
2013年 | 313篇 |
2012年 | 487篇 |
2011年 | 517篇 |
2010年 | 276篇 |
2009年 | 244篇 |
2008年 | 445篇 |
2007年 | 481篇 |
2006年 | 439篇 |
2005年 | 451篇 |
2004年 | 422篇 |
2003年 | 411篇 |
2002年 | 433篇 |
2001年 | 75篇 |
2000年 | 46篇 |
1999年 | 82篇 |
1998年 | 98篇 |
1997年 | 85篇 |
1996年 | 102篇 |
1995年 | 67篇 |
1994年 | 55篇 |
1993年 | 62篇 |
1992年 | 46篇 |
1991年 | 46篇 |
1990年 | 51篇 |
1989年 | 57篇 |
1988年 | 61篇 |
1987年 | 40篇 |
1986年 | 19篇 |
1985年 | 17篇 |
1984年 | 22篇 |
1983年 | 28篇 |
1982年 | 19篇 |
1981年 | 20篇 |
1980年 | 7篇 |
1978年 | 11篇 |
1977年 | 8篇 |
1974年 | 8篇 |
1970年 | 7篇 |
1968年 | 6篇 |
1966年 | 7篇 |
排序方式: 共有7397条查询结果,搜索用时 15 毫秒
81.
A case of primary malignant lymphoma of the duodenum successfully treated with dose escalating chemotherapy 总被引:3,自引:0,他引:3
Oshiro A Nagasaki A Nakachi A Uchima N Hasegawa H Nakazato T Nakamoto M Kinjo N Kinjo F Taira N Masuda M Takasu N 《Gan to kagaku ryoho. Cancer & chemotherapy》2003,30(8):1169-1173
A 65-year-old woman with diabetes mellitus was hospitalized for heart failure and anemia in August 2001, and recovered with conservative treatment. An endoscopic examination revealed an ulcerative mass located in the duodenal bulb to the 2nd portion. Abdominal CT scan demonstrated tumor involvement in the pancreas head. The diagnosis of a diffuse large B-cell lymphoma, clinical stage IIE, was made by endoscopic biopsy. Although surgical resection of the localized intestinal tumor would have been a common choice for initial treatment, polychemotherapy was selected; the patient had diabetes mellitus and preferred polychemotherapy to surgical operation. Because of bulky intestinal mass, transmural disease and sensitive histological type, standard-dose chemotherapy was considered to include a high risk of intestinal perforation. We performed dose-escalating chemotherapy: A half dose of THP-COP (pirarubicin, cyclophosphamide, vincristine) was given at the start in October 2001, 60% THP-COP as the next cycle, 80% THP-COP as the 3rd cycle and thereafter. Without serious complications of the intestine, she received a total of 6 cycles of chemotherapy and subsequent involved field radiation. There has been no evidence of recurrence of disease 14 months from the start of chemotherapy. When conditions make surgical treatment difficult, dose-escalating chemotherapy in a treatment cycle may be considered as an alternative. 相似文献
82.
Takatoshi Aoki Toshihiro Miyamoto Yasuo Mori Goichi Yoshimoto Takuji Yamauchi Kenjiro Kamezaki Katsuto Takenaka Hiromi Iwasaki Naoki Harada Koji Nagafuji Nobuyuki Shimono Takanori Teshima Koichi Akashi 《Mycoses》2011,54(4):e255-e259
Invasive aspergillosis (IA) is an important cause of infectious morbidity and mortality in patients who undergo haematopoietic stem cell transplantation (HSCT). History of IA before allogeneic HSCT is still challenging because of the high risk of recurrence after HSCT. Recent advances in early‐stage diagnosis and new, more effective classes of antifungal agents have improved the management of IA in the HSCT recipients. We report two cases with acute myelogenous leukaemia after primary failure of induction chemotherapy with the patients developing pulmonary IA. They responded well to a combination of voriconazole (VCZ) and micafungin, resulting in a remarkable reduction of pulmonary IA lesions at short intervals. Thereafter, antifungal therapy was switched to liposomal amphotericin B (L‐AmB), followed by conditioning regimen for allogeneic HSCT, because of the possibility of VCZ altering the metabolism of chemotherapeutic agents and calcineurin inhibitors. Successful engraftment was achieved without severe adverse side‐effects or aggravation of IA after HSCT. Combining VCZ with micafungin followed by L‐AmB throughout HSCT could be advantageous in stabilising IA in HSCT patients. 相似文献
83.
84.
Yuki Mori Shuya Matsuda Mitsuaki Sato Masaru Muraoka Yuichiro Suzuki Akihisa Tatsumi Yasuhiro Nakayama Taisuke Inoue Shinya Maekawa Nobuyuki Enomoto 《Internal medicine (Tokyo, Japan)》2022,61(18):2721
Objective Owing to advances in direct-acting antiviral (DAA) therapy, a considerable number of patients with hepatitis C virus (HCV)-positive hepatocellular carcinoma (HCC) are now able to achieve a sustained viral response (SVR) after curative treatment of HCC. However, the beneficial effect of a DAA-SVR on the survival remains unclear. Methods A total of 205 patients with HCC who were HCV-positive with Child-Pugh A at the onset from 2008 to 2018 were categorized into 2 groups: 140 patients untreated for HCV throughout the entire course after HCC development (untreated group) and 65 patients treated for HCV with DAAs following HCC treatment who achieved an SVR (SVR group). After propensity score matching, 63 patients from each group were selected. Using these patients, the survival and maintenance of Child-Pugh A after HCC treatment were compared between the untreated group and SVR group. Results There was a significant difference in the overall survival (p<0.001) and the rate of maintaining Child-Pugh A (p<0.001) between the groups. The 5-year survival rates were 96% (SVR group) and 60% (untreated group), and the proportions of patients with Child-Pugh A at 5 years after HCC treatment were 96% (SVR group) and 38% (untreated group). Conclusion In patients with HCV-positive HCC, achieving a DAA-SVR after HCC treatment significantly improved the overall survival rate compared with HCV-untreated patients. The contribution of DAA-SVR during the course of HCC treatment to a longer survival is mainly due to the prevention of the progression of Child-Pugh A to B/C. Further research is needed to determine whether aggressive antiviral therapy is also effective for HCC patients with Child-Pugh B/C. 相似文献
85.
Takeshi YOSHIMOTO Hiroshi YAMAGAMI Nobuyuki SAKAI Kazunori TOYODA Yoichiro HASHIMOTO Teruyuki HIRANO Toru IWAMA Rei GOTO Kazumi KIMURA Satoshi KURODA Yuji MATSUMARU Susumu MIYAMOTO Kuniaki OGASAWARA Yasushi OKADA Yoshiaki SHIOKAWA Yasushi TAKAGI Teiji TOMINAGA Masaaki UNO Shinichi YOSHIMURA Nobuyuki OHARA Hirotoshi IMAMURA Chiaki SAKAI 《Neurologia medico-chirurgica》2022,62(8):369
This study aimed to measure the impact of the COVID-19 pandemic on the volumes of annual stroke admissions compared with those before the pandemic in Japan. We conducted an observational, retrospective nationwide survey across 542 primary stroke centers in Japan. The annual admission volumes for acute stroke within 7 days from onset between 2019 as the pre-pandemic period and 2020 as the pandemic period were compared as a whole and separately by months during which the epidemic was serious and prefectures of high numbers of infected persons. The number of stroke patients declined from 182,660 in 2019 to 178,083 in 2020, with a reduction rate of 2.51% (95% confidence interval [CI], 2.58%-2.44%). The reduction rates were 1.92% (95% CI, 1.85%-2.00%; 127,979-125,522) for ischemic stroke, 3.88% (95% CI, 3.70%-4.07%, 41,906-40,278) for intracerebral hemorrhage, and 4.58% (95% CI, 4.23%-4.95%; 13,020-12,424) for subarachnoid hemorrhage. The admission volume declined by 5.60% (95% CI, 5.46%-5.74%) during the 7 months of 2020 when the epidemic was serious, whereas it increased in the remaining 5 months (2.01%; 95% CI, 1.91%-2.11%). The annual decline in the admission volume was predominant in the five prefectures with the largest numbers of infected people per million population (4.72%; 95% CI, 4.53%-4.92%). In conclusion, the acute stroke admission volume declined by 2.51% in 2020 relative to 2019 in Japan, especially during the months of high infection, and in highly infected prefectures. Overwhelmed healthcare systems and infection control practices may have been associated with the decline in the stroke admission volume during the COVID-19 pandemic. 相似文献
86.
Yuzo Deguchi Takatoshi Maeno Yuichi Hori Nobuyuki Hiruta Daisuke Sasai Yukihiro Sato 《Case reports in ophthalmology》2014,5(2):226-230
Introduction
To report a case in which intraocular silicone oil migrated into the upper eyelid and caused ptosis.Methods
A 65-year-old woman presented with proliferative vitreoretinopathy in the right eye. Vitrectomies, injection of silicone oil and encircling were performed. Two months after the last operation, swelling of her right eyelid occurred.Result
Magnetic resonance imaging revealed moisture in the palpebral fat tissue. We incised the bulbar conjunctiva and confirmed silicone oil leakage from the vitreous cavity through the scleral button hole of the encircling suture. Postoperatively, the right upper eyelid swelling decreased. Histopathologically, dense macrophage infiltration was seen in the palpebral tissues.Conclusions
We report a rare case with a postoperative complication caused by silicone oil. In cases with swelling of the eyelid and decreased silicon oil in the vitreous cavity postoperatively, clinicians should consider the possibility of silicone oil leakage.Key words: Migration of silicone oil, Upper eyelid, Vitrectomy, Scleral buckling, Postoperative complication, Ptosis 相似文献87.
Bonpei Takase Katsumi Hayashi Satoko Takei Tetsuya Hisada Nobuyuki Masaki Masayoshi Nagata 《Internal medicine (Tokyo, Japan)》2022,61(14):2167
Coronavirus disease 2019 (COVID-19) has become a pandemic, and vaccines remain the only effective tools available for ending it. However, their side effects, such as syncope, which mimics sudden cardiac death, are serious concerns. We herein report 6 cases of delayed vasovagal syncope and presyncope (VVR) caused by COVID-19 vaccination among 25,530 COVID-19 patients. The prevalence of delayed VVR due to COVID-19 vaccination was 0.026%. In addition, no delayed VVR was found among 17,386 patients who received the influenza vaccine. Delayed VVR is likely to be overlooked if medical staff are not aware of this symptom. This report provides significant information regarding effects of COVID-19 vaccination. 相似文献
88.
Ryohei Yamamoto Hajime Yamazaki Seibi Kobara Hiromi Iizuka Yasukazu Hijikata Jun Miyashita Yuki Kataoka Nobuyuki Yajima Toshio Miyata Sugihiro Hamaguchi Takafumi Wakita Yosuke Yamamoto Shunichi Fukuhara 《Journal of general internal medicine》2023,38(5):1239
BackgroundThe burden of COVID-19 on healthcare workers (HCWs) is reported to be increasing, yet the psychometric scales now in use evaluate only single aspects; few measure the pandemic-specific burden on HCWs comprehensively.ObjectiveTo develop a scale to quantify the physical, mental, and socioeconomic burden of the COVID-19 pandemic on HCWs.DesignScale development and cross-sectional survey.ParticipantsConsenting HCWs aged ≥20.Main MeasuresDevelopment of an item-list based on literature reviews and HCW panel input, evaluation of content validity and item selection using the Delphi method, psychometric testing conducted on HCWs, validity assessment by factor analyses and hypothesis verification, internal consistency evaluation by Cronbach’s alpha, test-retest analysis, and interpretability assessment.Key ResultsThrough the Delphi process, a 29-item pilot scale was generated. In psychometric testing, data from 863 HCWs contributed to the development of the final version of this scale, called Pandemic Burden Index twenty for HCWs (PBI-20), a 20-item scale to measure six domains: fatigue, fear of infection, inadequacy as a medical professional, mental health concerns, prejudice or discrimination, and anxiety about one’s livelihood and daily life. Factor analysis showed each factor corresponded to the six domains of this scale. Hypothesis verification showed the PBI-20 total score to be moderately to highly correlated with the Short Form 36 vitality score and mental health score and with intention of turnover. The PBI-20 had good internal consistency (Cronbach’s alpha 0.92). Test-retest analysis showed the intraclass correlation coefficient to be 0.70 and the minimal important change to be −7.0.ConclusionsThe psychometrically sound questionnaire we developed to measure pandemic-specific burdens for HCWs provides an understanding of comprehensive burdens on HCWs and may serve to evaluate interventions to reduce the burdens.Supplementary InformationThe online version contains supplementary material available at 10.1007/s11606-023-08028-3.KEY WORDS: COVID-19, pandemic, burden, health personnel, psychometrics 相似文献
89.
Hirotomo Dochi Satoru Kondo Takayuki Murata Masaki Fukuyo Asuka Nanbo Kousho Wakae WenPing Jiang Toshihide HamabeHoriike Mariko Tanaka Takumi Nishiuchi Harue Mizokami Makiko MoriyamaKita Eiji Kobayashi Nobuyuki Hirai Takeshi Komori Takayoshi Ueno Yosuke Nakanishi Miyako Hatano Kazuhira Endo Hisashi Sugimoto Naohiro Wakisaka ShinHun Juang Masamichi Muramatsu Atsushi Kaneda Tomokazu Yoshizaki 《Cancer science》2022,113(8):2862
90.
Haruka Yoshida Hiroki Takahashi Hiromichi Akoshima Nobuyuki Chida Kenji Noguchi Nobukazu Tanabe Yutaka Mano Katsuaki Ukai Keiichi Tadokoro 《Clinical journal of gastroenterology》2013,6(3):231-236
In January 2008, a 67-year-old woman was admitted to our hospital because of hepatitis C virus-related cirrhosis and hepatocellular carcinoma (HCC). In February 2010, she had tarry stools and anemia resulting from gastric antral vascular ectasia (GAVE). Argon plasma coagulation (APC) treatment for GAVE was performed at that time. She revisited our hospital in July 2010 because of tarry stools and anemia caused by GAVE recurrence, which required 5 APC sessions and blood transfusion to control the bleeding. In October 2010, she arrived at our hospital by ambulance because of hemorrhagic shock resulting from GAVE recurrence. Despite performing 5 APC sessions and multiple blood transfusions, the tarry stools and anemia persisted during the hospitalization period. In December 2010 and January 2011, second-stage selective transcatheter arterial embolization (TAE) of the right gastric and right gastroepiploic arteries using microcoils was performed for the treatment of the refractory GAVE. Upper gastrointestinal endoscopy performed after TAE revealed the disappearance of mucosal diffuse spotty redness. In addition, no complications such as gastric ulcer and necrosis were observed. Selective TAE, effectively resolved the GAVE and anemia, and no recurrence has been observed during the last 24 months. Therefore, TAE may be a safe and radical treatment for refractory GAVE. 相似文献