全文获取类型
收费全文 | 4798篇 |
免费 | 188篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 50篇 |
儿科学 | 95篇 |
妇产科学 | 72篇 |
基础医学 | 759篇 |
口腔科学 | 82篇 |
临床医学 | 256篇 |
内科学 | 997篇 |
皮肤病学 | 49篇 |
神经病学 | 622篇 |
特种医学 | 160篇 |
外科学 | 776篇 |
综合类 | 35篇 |
预防医学 | 153篇 |
眼科学 | 69篇 |
药学 | 329篇 |
中国医学 | 10篇 |
肿瘤学 | 490篇 |
出版年
2023年 | 17篇 |
2022年 | 42篇 |
2021年 | 72篇 |
2020年 | 45篇 |
2019年 | 63篇 |
2018年 | 71篇 |
2017年 | 67篇 |
2016年 | 67篇 |
2015年 | 70篇 |
2014年 | 70篇 |
2013年 | 140篇 |
2012年 | 234篇 |
2011年 | 246篇 |
2010年 | 164篇 |
2009年 | 144篇 |
2008年 | 253篇 |
2007年 | 279篇 |
2006年 | 291篇 |
2005年 | 303篇 |
2004年 | 342篇 |
2003年 | 355篇 |
2002年 | 312篇 |
2001年 | 83篇 |
2000年 | 87篇 |
1999年 | 76篇 |
1998年 | 103篇 |
1997年 | 86篇 |
1996年 | 64篇 |
1995年 | 58篇 |
1994年 | 60篇 |
1993年 | 75篇 |
1992年 | 57篇 |
1991年 | 57篇 |
1990年 | 55篇 |
1989年 | 51篇 |
1988年 | 35篇 |
1987年 | 35篇 |
1986年 | 31篇 |
1985年 | 38篇 |
1984年 | 36篇 |
1983年 | 28篇 |
1982年 | 17篇 |
1981年 | 27篇 |
1980年 | 28篇 |
1979年 | 19篇 |
1978年 | 18篇 |
1977年 | 28篇 |
1976年 | 22篇 |
1975年 | 10篇 |
1974年 | 12篇 |
排序方式: 共有5004条查询结果,搜索用时 93 毫秒
91.
Novel PSTPIP1 gene mutation in pyoderma gangrenosum,acne and suppurative hidradenitis syndrome
下载免费PDF全文
![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
92.
The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is one of the most commonly deregulated pathways in human cancers. PI3K comprises a catalytic (p110α) and regulatory subunit (p85), and p110α is encoded by the PIK3CA gene. Here, we summarize the known genetic alterations, including amplifications and mutations, of the PIK3CA oncogene in oral cancer. We discuss in detail PIK3CA mutations and their mutual exclusivity with pathway genes in addition to the incidence of PIK3CA mutations in relation to ethnicity. We describe the constitutive activation of PI3K signaling, oncogenicity, and the genetic deregulation of the PIK3CA gene and its association with oral cancer disease stage. We emphasize the importance of therapeutically targeting the genetically deregulated PIK3CA oncogene and its signaling. We also discuss the implications of targeting Akt and/or mTOR, which are the downstream effectors of PI3K that may possibly pave the way for molecular therapeutic targets for PIK3CA-driven oral carcinogenesis. Furthermore, this critical review provides a complete picture of the PIK3CA oncogene and its deregulation in oral cancer, which may facilitate early diagnosis and improve prognosis through personalized molecular targeted therapy in oral cancer. 相似文献
93.
94.
95.
96.
97.
Masaru Kubota Koji Narita Tadayoshi Nakagomi Akira Tamura Hiroyuki Shimasaki Nobuo Ueta 《Neurological research》2013,35(4):337-341
AbstractTo better define the sphingolipid metabolism during focal brain ischemia, levels of ceramide, sphingomyelin, cerebroside and gangliosides were determined in rat cerebral cortex during focal ischemia produced by occlusion of the middle cerebral artery. Sphingomyelin began to decrease at 2 hours of ischemia and continued to decrease for 96 hours. In contrast, ceramide increased at 6 hours and increased to 4.2-fold at 96 hours after ischemia, and the fatty acid composition of ceramide was solely nonhydroxylated fatty acid similar to sphingomyelin. Hydroxylated fatty acid-linked cerebroside decreased at 6 hours of ischemia, whereas any significant decrease of nonhydroxylated fatty acid-linked cerebroside didn't occur for 96 hours of ischemia. There were no measurable changes in the levels of gangliosides. These results suggested that ceramide was produced in the cerebral cortex by the breakdown of sphingomyelin during early ischemia. [Neurol Res 1996; 18: 337-341] 相似文献
98.
Yoshiyuki Kurata Machiko Oshida Hironori Take Takayasu Furubayashi Hirohisa Nakao Yoshiaki Tomiyama Yoshio Kanayama Nobuo Nagao Yasuto Okubo Takeshi Yonezawa and Seiichiro Tarui 《Vox sanguinis》1989,57(3):199-204
A new method was studied for eliminating HLA class I antigens from the surface of platelets without damaging the cells. Platelets were exposed to an acid solution (pH 3.0) to eliminate the antigenicity of HLA class I antigens. The reduction in antigenicities of HLA class I common antigen and individual HLA class I antigens by acid treatment was marked. Patients' sera which contained multispecific HLA antibodies reacted with PBS-treated platelets, but not with acid-treated platelets. No changes were observed in the antigenicities of glycoprotein Ib or glycoprotein IIb/IIIa. The viability of acid-treated platelets was 83%. Ultrastructural investigations revealed no significant difference between the PBS-treated platelets and acid-treated platelets. The platelet function studies showed that the aggregation of acid-treated platelets induced by various agonists was only slightly reduced compared with PBS-treated platelets. We propose that acid-treated platelets are promising for clinical use in patients refractory to platelet transfusions and may be superior to chloroquine-treated platelets for analysis of the specificity of antiplatelet antibodies. 相似文献
99.
100.
Tanimoto TE Yamaguchi T Tanaka Y Saito A Tajima K Karasuno T Kasai M Kishi K Mori T Maseki N Morishima S Miyakoshi S Kasai M Ohno Y Kim SW Numata A Kami M Takaue Y Mori S Harada M 《British journal of haematology》2004,125(4):480-493
A reduced incidence of graft versus host disease (GvHD) has been documented among Japanese allogeneic bone marrow transplantation (BMT) patients, as the Japanese are genetically more homogeneous than western populations. To clarify whether this ethnic difference affects the results of allogeneic peripheral blood stem cell transplantation (PBSCT), we conducted a nationwide survey to compare clinical outcomes of allogeneic PBSCT (n = 214) and BMT (n = 295) from a human leucocyte antigen-identical-related donor in Japanese patients. The cumulative incidence of grades II-IV acute GvHD was 37.4% for PBSCT and 32.0% for BMT. The cumulative incidence of extensive chronic GvHD at 1 year was significantly higher after PBSCT than BMT (42% vs. 27%; P < 0.01). The organ involvement patterns of GvHD were different between the two groups. By multivariate analyses, the incidence of chronic GvHD was significantly increased in PBSCT, whereas the stem cell source did not affect the incidence of acute GvHD, transplant-related mortality, relapse or survival. We concluded that Japanese PBSCT patients have an increased risk of chronic GvHD compared with BMT patients, but the incidence of acute GvHD was still lower than in western populations. Thus, the choice of haematopoietic stem cell source should be considered based on data for individual ethnic populations. 相似文献