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61.
62.
Kayoko Sugawara Mie Inao Nobuaki Nakayama Satoshi Mochida 《Journal of gastroenterology》2014,49(2):363-368
Background
The significance of retinopathy during triple therapy with telaprevir is uncertain.Methods
Ophthalmologic examination was done prospectively before and every month during the therapy in 95 CHC patients.Results
Retinopathy was found in 46 (48.4 %), and the specialists recommended discontinuation of the therapy in 9 (9.5 %). Such lesions may develop as adverse effects by telaprevir, since the lesions disappeared following discontinuation of telaprevir in a 65-year-old man, in whom both pegylated-interferon (Peg-IFN) and ribavirin were continued, and reappeared when he took telaprevir again by his decision. Multivariate analysis revealed that interleukin 28B single-nucleotide polymorphism (IL28B SNP) and anemia development during the therapy were independent factors associating retinopathy.Conclusion
Ophthalmologic examinations should be done carefully during triple therapy, since the incidence was higher than that in previous Peg-IFN therapy, and lesions may develop as adverse effects by telaprevir, but not by Peg-IFN, especially in those showing preferable IL28B SNPs allele and/or anemia during the therapy. 相似文献63.
Hideki Ishibashi So Imakiire Maki Goto Ryohei Nomaru Mamoru Shibata Hiroki Matsuoka Hideki Yasuda Tomomi Yamashima Hideto Sakisaka Taro Tanabe Satoshi Matsuoka Nobuaki Kuno Koichi Abe Sadahiro Funakoshi Yasushi Takamatsu Fumihito Hirai Morishige Takeshita 《Internal medicine (Tokyo, Japan)》2022,61(3):329
A 60-year-old Japanese woman was diagnosed with celiac disease (CeD) and treated with a gluten-free diet. For five years, she had a good clinical course. However, she complained of inappetence and nausea. Colonoscopy revealed ulcerative tumors in the terminal ileum. A histological examination of biopsy specimens from the ulcerative tumor showed diffuse infiltration of large atypical lymphocytes. Immunohistologically, the atypical lymphoid cells were positive for cluster of differentiation (CD)10 and CD20. Many Epstein-Barr virus-encoded small RNA (EBER)-positive atypical lymphocytes were detected by in situ hybridization. This represents the first reported case of Epstein-Barr virus-positive intestinal diffuse large B-cell lymphoma complicated with CeD. 相似文献
64.
During mental rotation tasks using hand pictures, right-handers make left–right judgements by mentally rotating their own hand to an orientation of the presented hand image. Although strategy difference for the tasks between left- and right-handers has been suggested, the strategy of left-handers has been incompletely understood. In the present study we compared differences in reaction times between 15 left-handed and 16 right-handed normal individuals during a mental rotation task using simple hand pictures. Participants were required to identify pictures of a hand presented in four orientations (upright, counterclockwise rotated, clockwise rotated, and inverted) as either a right or a left hand. Right-handers recognised a right hand faster than a left hand, whereas no significant difference was seen for left-handers. Both left- and right-handers recognised a right hand faster than a left hand in counterclockwise-rotated images, and recognised a left hand faster than a right hand in clockwise-rotated images. The findings suggest that the differences in the reaction times between left- and right-handers depend on a laterality balance of hand motor skills. During mental rotation task using simple hand pictures, left-handers may mentally simulate their own hand to match the stimulus image as similar to right-handers. 相似文献
65.
Matsushima N Hirose S Iwata H Fukuma G Yonetani M Nagayama C Hamanaka W Matsunaka Y Ito M Kaneko S Mitsudome A Sugiyama H 《Epilepsy research》2002,48(3):181-186
To date five mutations in two major constituents of neuronal nicotinic acetylcholine receptor (nAChR) in the brain, i.e. alpha4 and beta2 subunits, have been identified to be associated with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). Among them, only Ser284Leu, a point mutation in alpha4 subunit identified in ADNFLE as well as in a sporadic case with nocturnal frontal lobe epilepsy, remains to be characterized electrophysiologically. We examined the properties of rat nAChR harboring Ser284Leu reconstituted on Xenopus oocytes. Currents elicited in response to application of acetylcholine to oocytes expressing wild type or mutant nAChR were measured by a standard two-microelectrode voltage clamp method. Compared with wild-type nAChR, the mutant nAChR had a comparable EC(50) value for acetylcholine whereas it showed faster desensitization and lower Cs(+)/Na(+) permeability ratio. Ser284Phe, a putative mutation constructed for comparison, exhibited similar properties. These findings indicate that Ser(284) plays an important role in gating of nAChR along with Thr(276) and Ser(280), and suggest that mutation at Ser(284) could reduce nAChR activity similar to other mutations of alpha4 subunit found in ADNFLE. 相似文献
66.
Haruhiko Ogawa Masaki Fujimura Motoyasu Saito Tamotsu Matsuda Nobuaki Akao Kaoru Kondo 《Clinical autonomic research》1994,4(1-2):19-28
Eosinophilic bronchitis without asthma can cause a persistent non-productive cough which is resistant to bronchodilator therapy. To understand the mechanism of the cough in this disorder, an animal model of eosinophilic bronchitis was developed. Guinea-pigs were treated with transnasal administration of polymyxin B or saline twice a week for 3 weeks. The number of eosinophils in bronchoalveolar lavage fluid increased in polymyxin B-treated animals when compared with those treated with saline. In addition, histological examination showed that the number of eosinophils infiltrated into the tracheal epithelium increased; injury to the tracheal epithelium was greater in polymyxin B-treated animals. The numbers of coughs induced by saline and each concentration of capsaicin (10–18, 10–16, 10–14M) were greater in the polymyxin B-treated animals. FK-224 (a neurokinin receptor antagonist) decreased the heightened cough reflex in this animal model of eosinophilic bronchitis. These findings suggest that neuropeptides, and particularly neurokinins, are involved in the heightened cough receptor sensitivity in eosinophilic bronchitis without asthma. This has implications for better understanding of this disorder and its treatment. 相似文献
67.
Dr. Kunihiko Ohnishi MD Akihiko Mishima MD Motohide Takashi MD Seiji Tsuchiya MD Shinji Iida MD Shosuke Iwama MD Nobuaki Goto MD Kunihiko Kono MD Yukio Nakajima MD Naondo Suzuki MD Hirotaka Musha MD Kunio Okuda MD 《Digestive diseases and sciences》1983,28(3):201-206
To study the effects of intra- and extrahepatic portal-systemic shunts on insulin degradation, 11 patients with liver cirrhosis and 7 noncirrhotic patients with liver disease were studied with percutaneous transhepatic catheterization. Insulin levels in portal and peripheral blood were measured simultaneously for 1-2 hr after intravenous administration of glucose. The degrees of intra- and extrahepatic portal-systemic shunting were measured with this technique using 131I-macroaggregated albumin and 99mTc-macroaggregated albumin. The amount of insulin secreted and insulin degraded were assessed from the areas under blood concentration curves for portal and peripheral blood. Insulin degradation was significantly reduced in cirrhotics compared to noncirrhotics with liver disease, although there was no difference in the amount of insulin secreted between these two groups. It was also correlated significantly with the degree of intrahepatic shunting but not with the degree of extrahepatic shunting. These results suggest that intrahepatic shunting plays an important role in the reduction of insulin degradation in cirrhosis. 相似文献
68.
Nakayama Nobuaki Uemura Hayato Uchida Yoshihito Imai Yukinori Tomiya Tomoaki Terai Shuji Yoshiji Hitoshi Genda Takuya Ido Akio Inoue Kazuaki Kato Naoya Sakaida Isao Shimizu Masahito Takikawa Yasuhiro Abe Masanori Abe Ryuzo Chayama Kazuaki Hasegawa Kiyoshi Inui Ayano Kasahara Mureo Ohira Hiromasa Tanaka Atsushi Takikawa Hajime Mochida Satoshi 《Journal of gastroenterology》2021,56(12):1092-1106
Journal of Gastroenterology - The significance of the 2018 Japanese diagnostic criteria for acute-on-chronic liver failure (ACLF) has not yet been evaluated. A nationwide survey was performed for... 相似文献
69.
Analysis of mRNA with microsomal fractionation using a SAGE-based DNA microarray system facilitates identification of the genes encoding secretory proteins 总被引:1,自引:0,他引:1 下载免费PDF全文
Toyoda N Nagai S Terashima Y Motomura K Haino M Hashimoto S Takizawa H Matsushima K 《Genome research》2003,13(7):1728-1736
In the regulation of host defense responses such as inflammation and immunity, the secretory proteins, including membrane proteins, play central roles. Although many secretory proteins have been identified by using methods such as differential display, random screening, or the signal sequence trap method, each method suffers from poor reproducibility, low sensitivity, or time-consuming or laborious work. Therefore, the strategy for facilitating the selection of the genes encoding the secretory proteins is desired. In this paper, we describe a system for isolating the genes encoding secretory proteins by analyzing mRNAs with microsomal fractionation on serial analysis of gene expression (SAGE)-based DNA microarray system. This system succeeded in discriminating the genes encoding secretory proteins from ones encoding nonsecretory proteins with 80% accuracy. We applied this system to human T lymphocytes. As a result, we were able to identify the genes that are not only encoding secretory proteins but also expressing selectively in a specific subset of T lymphocytes. The SAGE-based DNA microarray system is a promising system to identify the genes encoding specific secretory proteins. 相似文献
70.
Medical procedures and outcomes of Japanese patients with trisomy 18 or trisomy 13: Analysis of a nationwide administrative database of hospitalized patients 下载免费PDF全文