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141.
Solntseva S. V. Nikitin V. P. Kozyrev S. A. Nikitin P. V. 《Bulletin of experimental biology and medicine》2022,172(5):528-533
Bulletin of Experimental Biology and Medicine - Impairment of reconsolidation of conditioned food aversion memory led to the development of a specific anterograde amnesia: repeated training of... 相似文献
142.
Dodokhova M. A. Kotieva I. M. Safronenko A. V. Alkhusein-Kulyaginova M. S. Sukhorukova N. V. Kotieva V. M. Kotieva E. M. Starostin S. I. Shpakovsky D. B. Nikitin E. A. Milaeva E. R. 《Bulletin of experimental biology and medicine》2022,173(5):620-622
Bulletin of Experimental Biology and Medicine - We performed a comparative analysis of the pharmacological activity of the hybrid organotin compound... 相似文献
143.
Chalmers RM; Howard RS; Wiles CM; Hirsch NP; Miller DH; Williams A; Spencer GT 《QJM : monthly journal of the Association of Physicians》1996,89(6):469-476
Twenty-nine patients with a neuronopathic or neuropathic disorder were
referred for assessment of respiratory insufficiency between 1978 and 1994.
Diagnoses included spinal muscular atrophy (6), chronic idiopathic
demyelinating neuropathy (4), Vialetto-van Laere syndrome (3), hereditary
motor and sensory neuropathy (3) and a miscellaneous group (5). We also
describe seven patients with Guillain-Barre syndrome (GBS) who required
long-term ventilatory support for over 6 months to 7 years after the
initial illness. Respiratory insufficiency occurred as a consequence of
respiratory muscle weakness, impaired bulbar function and restrictive lung
defects. In some groups presentation was with progressive nocturnal
hypoventilation culminating in acute respiratory failure. Five patients
with GBS or chronic idiopathic demyelinating neuropathy were weaned from
ventilatory support up to 18 months after the initial illness. The
remaining 24 patients required continuous or nocturnal ventilatory support
using intermittent positive-pressure ventilation (13), negative pressure
ventilation (4), nasal-mask-delivered intermittent positive-pressure
ventilation (4), nasal-mask-delivered continuous positive-pressure
ventilation (3), mouthpiece-assisted ventilation by day (2) and rocking bed
(1). None have been weaned from support after a period of ventilation
ranging from one month to 10 years. Eight patients have subsequently died.
相似文献
144.
Alyssa Izquierdo BS Franziska Plessow PhD Kendra R. Becker PhD Christopher J. Mancuso BS Meghan Slattery NP Helen B. Murray BA Andrea S. Hartmann PhD Madhusmita Misra MD MPH Elizabeth A. Lawson MD Kamryn T. Eddy PhD Jennifer J. Thomas PhD 《The International journal of eating disorders》2019,52(4):419-427
145.
146.
Mahmoud Kaddoura PhD CAGS APRN NP‐C CNE Olga Van‐Dyke PhD CAGS MSN RN Qing Yang PhD 《Nursing & health sciences》2016,18(3):350-354
Nurses confront complex problems and decisions that require critical thinking in order to identify patient needs and implement best practices. An active strategy for teaching students the skills to think critically is the concept map. This study explores the development of critical thinking among nursing students in a required pathophysiology and pharmacology course during the first year of a Bachelor of Science in Nursing in response to concept mapping as an interventional strategy, using the Health Education Systems, Incorporated critical thinking test. A two‐group experimental study with a pretest and posttest design was used. Participants were randomly divided into a control group (n = 42) taught by traditional didactic lecturing alone, and an intervention group (n = 41), taught by traditional didactic lecturing with concept mapping. Students in the concept mapping group performed much better on the Health Education Systems, Incorporated than students in the control group. It is recommended that deans, program directors, and nursing faculties evaluate their curricula to integrate concept map teaching strategies in courses in order to develop critical thinking abilities in their students. 相似文献
147.
The effects of alpha and beta blockade on ventilatory responses to exercise in chronic heart failure 总被引:1,自引:0,他引:1
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Witte KK Thackray SD Nikitin NP Cleland JG Clark AL 《Heart (British Cardiac Society)》2003,89(10):1169-1173
Objective: To assess the influence of acute α and β blockade on ventilation and symptoms of breathlessness during exercise in patients with chronic heart failure and in controls. 相似文献
148.
Alexey G. Nikitin Dimitry A. Chistiakov Larissa O. Minushkina Dmitry A. Zateyshchikov Valery V. Nosikov 《Heart and vessels》2010,25(3):229-236
Abnormalities in lipid metabolism and enhanced oxidative stress are considered as major risk factors for coronary atherosclerosis.
Functional genetic variations in genes whose products are involved in lipid metabolism and antioxidant defense could therefore
modulate risk of coronary artery disease (CAD). In this study, we evaluate whether the PPARGC1A Gly482Ser, PPARG3 (−681)C/G, PPARD +294T/C, and CYBA +242C/T gene variants confer the risk of CAD in a Russian population. A total of 313 CAD patients and 132 controls with no
clinical sign of CAD were studied. The polymorphic markers were tested using a TaqMan assay. Allele and genotype frequencies
in CAD patients and controls were compared using the Yates χ2 test. Association of the genetic markers with metabolic risk factors of arterial atherosclerosis was studied using the analysis
of variance test and then adjusted for conventional risk factors in the multiple regression analysis. For CYBA +242C/T, both the allele T and genotype T/T showed significant association with higher risk of CAD (odds ratio =1.49 and
3.89, respectively). The allele C and genotype C/C of the +294T/C marker of PPARD were associated with increased risk of CAD providing an odds ratio of 2.12 and 2.78, respectively. The risk variants of CYBA +242C/T and PPARD +294T/C markers were associated with higher low-density lipoprotein cholesterol and increased total serum cholesterol, respectively.
In conclusion, the CYBA +242C/T and PPARD +294T/C variants modulate risk of CAD through their associations with atherogenic serum lipid profiles. 相似文献
149.
Elissa M. Ozanne PhD rea Loberg Sherwood Hughes Christine Lawrence Brian Drohan MS Alan Semine MD Michael Jellinek MD Claire Cronin MD Frederick Milham MD MBA Dana Dowd RN NP Caroline Block MD Deborah Lockhart John Sharko MS Georges Grinstein PhD Kevin S. Hughes MD 《The breast journal》2009,15(2):155-162
Abstract: Despite advances in identifying genetic markers of high risk patients and the availability of genetic testing, it remains challenging to efficiently identify women who are at hereditary risk and to manage their care appropriately. HughesRiskApps, an open-source family history collection, risk assessment, and Clinical Decision Support (CDS) software package, was developed to address the shortcomings in our ability to identify and treat the high risk population. This system is designed for use in primary care clinics, breast centers, and cancer risk clinics to collect family history and risk information and provide the necessary CDS to increase quality of care and efficiency. This paper reports on the first implementation of HughesRiskApps in the community hospital setting. HughesRiskApps was implemented at the Newton-Wellesley Hospital. Between April 1, 2007 and March 31, 2008, 32,966 analyses were performed on 25,763 individuals. Within this population, 915 (3.6%) individuals were found to be eligible for risk assessment and possible genetic testing based on the 10% risk of mutation threshold. During the first year of implementation, physicians and patients have fully accepted the system, and 3.6% of patients assessed have been referred to risk assessment and consideration of genetic testing. These early results indicate that the number of patients identified for risk assessment has increased dramatically and that the care of these patients is more efficient and likely more effective. 相似文献
150.
Fagard RH Stolarz K Kuznetsova T Seidlerova J Tikhonoff V Grodzicki T Nikitin Y Filipovsky J Peleska J Casiglia E Thijs L Staessen JA Kawecka-Jaszcz K 《Journal of hypertension》2007,25(11):2280-2285
OBJECTIVE: To assess, in a population-based approach, sympathetic nervous system activity by the use of power spectral analysis of heart rate variability, in normotension, white-coat hypertension, masked hypertension and sustained hypertension. METHODS: The electrocardiographic RR interval was registered in the supine and standing positions and the low-frequency and high-frequency components of its variability were quantified. Cut-off values of 140/90 mmHg for conventional blood pressure and 135/85 mmHg for daytime ambulatory blood pressure were used to define the four blood pressure groups. RESULTS: After exclusion of patients with diabetes, myocardial infarction or treated hypertension, 1485 subjects with complete data remained for the analysis in the supine position. Age averaged 39 +/- 14 years; 54% were women. Conventional and ambulatory blood pressure averaged, respectively, 122 +/- 16/79 +/- 11 mmHg and 124 +/- 12/77 +/- 8 mmHg. After adjusting for demographic, anthropometric and lifestyle characteristics, the low-frequency to high-frequency ratio (geometric mean) averaged 0.81 in normotension and was significantly higher in white-coat hypertension (1.11; P < 0.001), based on a higher low-frequency component and a lower high-frequency component (P < 0.01). This ratio was not significantly different between normotension, masked hypertension (0.97) and sustained hypertension (0.93). The adjusted standing-to-supine ratio of the high-frequency component (geometric mean) was significantly higher in sustained hypertension (0.50) than in normotension (0.39; P < 0.01), but not in white-coat (0.40) and masked hypertension (0.45). CONCLUSION: The findings at rest are compatible with increased sympathetic activity and decreased parasympathetic modulation in white-coat hypertension, with normal autonomic cardiac regulation in masked and sustained hypertension. In addition, sustained hypertension is characterized by a blunted decrease of the high-frequency component on standing. 相似文献