Ueber die Verbreitung der Faserdegenerationen bei amyotrophischer Lateralsklerose mit besonderer Berücksichtigung der Veränderungen im Grosshirn

Ohne Zusammenfassung     

Comparison of sphingomyelinase activity in liver cell nuclei and in the brain

Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. A. M. Gor'kii Kharkov University. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 108, No. 9, pp. 287–289, September, 1989.     

Precise intraoperative location of gastrointestinal bleeding with a hand-held counter. Work in progress

The nuclear medicine bleeding scan is frequently insufficient to locate sites of bleeding precisely, in spite of its great sensitivity. A small, hand-held Geiger-Müller counter, placed directly on exposed intestine in the operating room, enables precise location of the probable bleeding site. In three patients, the technique allowed a minimal amount of intestine to be resected, distinguished between large- and small-intestinal hemorrhage, and eliminated other foci as sites of bleeding.     

Effects of agonists of NMDA and serotonin receptors at different stages of amnesia caused by impairment of long-term memory reconsolidation

Previously we showed that in snails that were conditioned for food aversion impairment of memory reconsolidation MK-801, an antagonist of N-methyl-D-aspartate (NMDA) receptors, induced amnesia, at the early stage of which (<10 days) memory was restored after repeated conditioning. In contrast, at the late stages (≥10 days) repeated training did not lead to memory restoration. In the present study, we induced amnesia by MK-801/reminding in snails 24 h after taste aversion conditioning, and then tested the effects of an agonist of NMDA receptors and a serotonin precursor 5-hydroxytryptophan (5-HTP) at the early (day 3) and late (day 12) stages of amnesia. We found that NMDA injection and reminding by conditioned food stimulus 3 days after amnesia induction did not lead to memory restoration. However, repeated conditioning 15 days after the amnesia induction led to the restoration of memory. NMDA injection alone, not followed by reexposure, did not influence amnesia development. NMDA injection combined with reminding 12 days after the amnesia induction, as well as 5-HTP injection combined with a reminding 3 days after amnesia induction were ineffective, and a second conditioning did not result in the restoration of the memory. Thus, we have demonstrated that NMDA receptor agonists have an antiamnestic effect only during the early phase of amnesia development, which is caused by memory reconsolidation disruption, whereas the late phase of amnesia is insensitive to the agonists.     

The entomological and acarological situation in Nizhegorod Province]

Ixodes, persulcatus, I. ricinus, D. reticulatus, D. marginatus, H. concinna were recorded in different regional environmental regions. The northern districts of the region are endemic for tick-borne encephalitis (TBE) and Ixodes tick-borne borreliosis (ITBB). The infection of ticks with TBE virus is 0.25%, that with Borrelia is 10.3% of the total number of the examinees. In 1997 TBE and TTBB morbidity rates were 1.91 and 2.0 per 100,000, respectively. Data on the phenology of prevailing Anopheles messeae are given. Human malaria contamination may take 99-102 days (the first ten days of June to the second ten days of September). The large size of malaria mosquitoes and the presence of imported cases of malaria make it possible to deteriorate the malaria epidemiological situation. The larvicidal activity of a preparation derived from shepherd's-purse (Capsella bursa pastoris) [correction of caseweed (Bursae pastoris)] was tested. 80-85% deaths of larvae of second-third ages occurred 48 hours after treatment with the preparation, 1 kg/ha.