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M. I. Ryakhovskaya E. V. Popova G. S. Grinenko A. I. Terekhina G. I. Gritsina V. B. Nikitin G. N. Engalycheva M. É. Kaminka R. G. Glushkov 《Pharmaceutical Chemistry Journal》1990,24(3):184-189
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 24, No. 3, pp. 26–29, March, 1990. 相似文献
14.
The authors review the results of estimating platelet spontaneous aggregation by Wu and Hoak's method and by its modifications. They describe a modification of the procedure that essentially improves the accuracy of investigation, is sufficiently sensitive, simple, and rapid. Its informative value was confirmed in experiments with spontaneous platelet aggregation in rabbits with cholesterolemia. 相似文献
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A M Zemskov V M Zemskov A V Nikitin V D Zazhire? E F Evstratova 《Terapevticheski? arkhiv》1989,61(3):65-68
Study of the immunologic reactivity of 104 patients with chronic obstructive bronchitis revealed the deficiency of cellular immunity for the most part. The use of timoptin, sodium nucleinate and their combined application raised the clinical efficacy of the treatment of patients with chronic obstructive bronchitis, significantly reduced the concentration of medium-weight molecules in blood serum, and corrected immunity disorders. 相似文献
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A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alphaC and follistatin during pregnancy 总被引:6,自引:1,他引:6
Fowler PA; Evans LW; Groome NP; Templeton A; Knight PG 《Human reproduction (Oxford, England)》1998,13(12):3530-3536
Maternal serum concentrations of inhibin-A, inhibin-B, activin-A,
activin-AB, pro-alphaC-related inhibin forms, total follistatin, steroids
and gonadotrophins were measured longitudinally in six normal singleton
pregnancies. Maternal venous blood was collected randomly during a
spontaneous follicular phase prior to donor insemination, at 5, 7, 9, 11,
16, 20, 24, 28, 32 and 36 weeks after the first missed menses and in the
early puerperium. Steroid and gonadotrophin profiles conformed to previous
reports. While at week 5 of gestation inhibin-A, activin-A and follistatin
concentrations were similar to those at the follicular phase, all three
increased progressively (P < 0.001) to maximal concentrations in week
36: approximately 48-fold (3740 +/- 1349 ng inhibin-A/ml), approximately
22-fold (6109 +/- 1443 ng activin-A/ml) and approximately 10-fold (3563 +/-
418 ng follistatin/ml) higher. Pro- alphaC concentrations reached a maximum
in weeks 5 (approximately 5- fold, P < 0.001) and 36 (1027 +/- 174
pg/ml, P < 0.01). Inhibin-B (71 +/- 23 pg/ml prior to pregnancy) was
undetectable (<12 pg/ml) between week 5-16 of gestation but increased
slightly in the third trimester (26 +/- 7 pg/ml in week 36). Activin-AB was
undetectable throughout pregnancy. Post-partum concentrations of inhibin-A
(41 +/- 12 ng/ml), inhibin-B (<12 pg/ml), activin-A (950 +/- 149 pg/ml),
pro-alphaC (128 +/- 22 pg/ml) and follistatin (990 +/- 79 ng/ml) were
substantially lower than at week 36 of gestation. The activin-A:follistatin
ratio increased from 0.5 in week 5 to 1.8 in week 36, suggesting that more
free activin-A is available in the maternal circulation during late
pregnancy.
相似文献
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Light and electron microscopy, histochemistry, histoautoradiography and vital staining were used to assess changes occurring in subcutaneous connective tissue surrounding a DMBA-containing pill in rats, samples being obtained at 2-week intervals until malignant fibrous histiocytoma became apparent. Initial tumor lesions developing against the background of alterative-inflammatory and reparative changes included apparently atypical pleomorphic cells showing cytologic signs of malignant transformation which remained virtually unchanged in developed sarcoma. The study, therefore, failed to identify the stage of "presarcoma". A complex of morphologic and functional characteristics of the atypical cells revealed their fibroblastic nature. Progression of tumor was associated with appearance of cells of histiocytic pattern (as evidenced by high activity of acid phosphatase and non-specific esterases, thin villus-like outgrowths of cellular membrane and well-developed Golgi complex) which pointed to pronounced structural and functional variability of poorly-differentiated neoplastic fibroblasts. Tumor revealed xanthomatous and multinuclear giant cells, too. Malignant fibrous histiocytoma is, therefore, poorly-differentiated polymorphocellular sarcoma of fibroblastic origin. 相似文献