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111.
Jeffrey M. Goldberg MD M. Steven Piver MD Ronald E. Hempling MD Christine Aiduk NP Leslie Blumenson PhD Fernando O. Recio MD 《Annals of surgical oncology》1998,5(5):399-406
Background: Since pelvic exenteration for the treatment of recurrent gynecologic malignancy first was described, reported rates of morbidity and mortality have declined steadily. However, the factors responsible for this decline have never been clearly delineated.
Methods: We reviewed the charts of 154 patients who underwent pelvic exenteration for gynecologic malignancy between 1954 and 1994. Charts were abstracted for details of the surgical procedure, pathologic findings, postoperative management, short- and long-term complications, time to recurrence, and overall survival.
Results: Seventy-two patients (47%) experienced 95 identifiable postoperative complications, resulting in death in 22 patients (14%). The rate of infectious complications declined to a statistically significant degree between the first two decades and latter two decades of the study (odds ratio [OR] 0.28, 95% CI 0.11–0.69). The use of routine prophylactic antibiotics was associated with this decline in infectious complications (OR 0.25, 95% CI 0.07–0.83). The use of preoperative subcutaneous heparin was associated with a reduction in thrombotic complications from 5 of 100 patients to 0 of 54 patients (P=.11), as well as a significant reduction in overall risk of complications (OR 0.53, 95% CI 0.33–0.85) and risk of postoperative mortality (OR 0.19, 95% CI 0.05–0.80). There was a significant reduction in overall risk of postoperative complications with both intensive care unit monitoring postoperatively (OR 0.65, 95% CI 0.43–0.99) and routine postoperative monitoring with a pulmonary artery catheter (OR 0.61, 95% CI 0.38–0.98).
Conclusions: Routine use of prophylactic antibiotics, prophylactic subcutaneous heparin, and intensive postoperative monitoring appear to have reduced morbidity from pelvic exenteration. 相似文献
112.
Translation and validation of the Canadian diabetes risk assessment questionnaire in China 下载免费PDF全文
Jia Guo RN PhD Zhengkun Shi RN MSN Jyu‐Lin Chen PhD Jane K. Dixon PhD James Wiley PhD Monica Parry NP‐Adult PhD 《Public health nursing (Boston, Mass.)》2018,35(1):18-28
Objectives
To adapt the Canadian Diabetes Risk Assessment Questionnaire for the Chinese population and to evaluate its psychometric properties.Design and Sample
A cross‐sectional study was conducted with a convenience sample of 194 individuals aged 35–74 years from October 2014 to April 2015.Methods
The Canadian Diabetes Risk Assessment Questionnaire was adapted and translated for the Chinese population. Test–retest reliability was conducted to measure stability. Criterion and convergent validity of the adapted questionnaire were assessed using 2‐hr 75 g oral glucose tolerance tests and the Finnish Diabetes Risk Scores, respectively. Sensitivity and specificity were evaluated to establish its predictive validity.Results
The test–retest reliability was 0.988. Adequate validity of the adapted questionnaire was demonstrated by positive correlations found between the scores and 2‐hr 75 g oral glucose tolerance tests (r = .343, p < .001) and with the Finnish Diabetes Risk Scores (r = .738, p < .001). The area under receiver operating characteristic curve was 0.705 (95% CI .632, .778), demonstrating moderate diagnostic value at a cutoff score of 30. The sensitivity was 73%, with a positive predictive value of 57% and negative predictive value of 78%.Conclusions
Our results provided evidence supporting the translation consistency, content validity, convergent validity, criterion validity, sensitivity, and specificity of the translated Canadian Diabetes Risk Assessment Questionnaire with minor modifications. This paper provides clinical, practical, and methodological information on how to adapt a diabetes risk calculator between cultures for public health nurses. 相似文献113.
E. Bellissant NP Chau C. Thuillez and JF Giudicelli 《Fundamental & clinical pharmacology》1994,8(5):437-445
Summary— Pinacidil (P) lowers blood pressure through peripheral vasodilation, but also induces dose-dependent side-effects. In a previous placebo-controlled, randomized, double-blind and crossover study, performed in six healthy male volunteers, we investigated the systemic and regional hemodynamic effects of a single oral administration of 25 mg of P (sustained-release form) and measured the plasma concentrations of P and of its active metabolite, pinacidil-N-oxide (PO). In the present study, our goal has been to investigate the relationships between P and/or PO plasma concentrations and P administration effects on systolic, diastolic and mean arterial pressures (SAP, DAP, MAP), heart rate (HR), cardiac output (CO), total peripheral resistance (TPR), brachial and carotid arteries' diameters (BAD, CAD), flows (BAF, CAF) and vascular resistances (BVR, CVR) which were assessed before and at different time intervals after drug intake. Concentration-effect relationships were investigated using both linear and log-linear multiple regression models with P, PO or both P and PO as independent variables (six models). Significant linear relationships were observed between P and/or PO and SAP, DAP, MAP, TPR, BAD, BAF, BVR, CAD and CVR. For example, TPR (dynes.s/cm5 ) = 1308 – 3.031 × P (ng/ml), R = 0.57, P = 0.0037; BVR (mmHg.s/ml) = 58 – 0.261 × P (ng/ml), R = 0.56, P = 0.0042. Almost similar R values were obtained using P, PO, or both P and PO. The use of log-linear models did not improve the fittings. We conclude that there are significant linear relationships between P plasma concentrations and most of P systemic and regional hemodynamic effects; this finding allows the determination of the best individual P dosage for inducing a given hemodynamic effect, and, using PO instead of P plasma concentrations does not improve the models and is thus useless. 相似文献
114.
Twice weekly pulse and daily continuous‐dose erlotinib as initial treatment for patients with epidermal growth factor receptor–mutant lung cancers and brain metastases 下载免费PDF全文
115.
Pilot study of a multimodal intervention to enhance sexual function in survivors of hematopoietic stem cell transplantation 下载免费PDF全文
Areej El‐Jawahri MD Sarah R. Fishman BA Julie Vanderklish NP Don S. Dizon MD Nicole Pensak PhD Lara Traeger PhD Joseph A. Greer PhD Elyse R. Park PhD Netana Markovitz BA Lauren Waldman BS Chrisa Hunnewell NP Meredith Saylor NP Jessica Driscoll NP Zhigang Li PhD Thomas R. Spitzer MD Steven McAfee MD Yi‐Bin Chen MD Jennifer S. Temel MD 《Cancer》2018,124(11):2438-2446
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Bone density,body composition,and psychopathology of anorexia nervosa spectrum disorders in DSM‐IV vs DSM‐5 下载免费PDF全文
Melanie Schorr MD Jennifer J. Thomas PhD Kamryn T. Eddy PhD Laura E. Dichtel MD MHS Elizabeth A. Lawson MD Erinne Meenaghan NP Margaret Lederfine Paskal BS Pouneh K. Fazeli MD Alexander T. Faje MD Madhusmita Misra MD MPH Anne Klibanski MD Karen K. Miller MD 《The International journal of eating disorders》2017,50(4):343-351
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120.
Structurally diverse molecular deletions in the beta-globin gene cluster exhibit an identical phenotype on interaction with the beta S- gene 总被引:3,自引:0,他引:3
We have characterized a new deletion that increases hemoglobin F synthesis in an American black woman who is doubly heterozygous for this mutation and the beta S-gene. The 5' endpoint is 2.4 +/- 0.1 kilobases (kb) upstream from the delta-globin gene, and the 3' endpoint is 0.2 +/- 0.1 kb downstream from the beta-globin gene; the deletion is 12 kb long. Both members of the Alu moderately repetitive DNA sequence family, normally present upstream from the delta-globin gene, are preserved. The patient is asymptomatic with a mild anemia and 24.8% HbF. The patient's husband and daughter have a similar clinical syndrome, with HbF levels of 22.4% and 25.4%, respectively. Both husband and daughter are doubly heterozygous for the beta S-gene and the Ghana type of hereditary persistence of fetal hemoglobin (HPFH) deletion (HPFH-2). The 5' end of this deletion is in the psi beta-gene, and its total length is more than 70 kb. All three members of the family have normocytic red cells, of which 95% or more are F cells as detected by immunofluorescence. Previous studies have shown that culture of the erythroid progenitors (BFU-E) from both types of these compound heterozygotes in the presence of fetal sheep serum, rich in "switching factor," resulted in complete suppression of HbF synthesis. Although the newly described deletion resembles the Sicilian type of delta beta-thalassemia by its size and preservation of the Alu sequences, the clinical and biological phenotype produced by its interaction with the beta S-gene is very similar to that of the HPFH- type deletion. 相似文献