Insulin-glucose parameters in healthy women and patients with arterial hypertension and ischemic heart disease in dependence on age and follicle-stimulating hormone levels

Insulin-glucose parameters in healthy women do not significantly change with changes of functional state of ovaries. Women with hypertension and normal levels of glycemia have significantly higher values of basal insulinemia and HOMA-R index reflecting presence of moderate insulin resistance degree of which is more pronounced in middle aged patients. In women with documented ischemic heart disease values of basal insulinemia, HOMA-R index, and glycemia are comparable with those in patients with hypertension and follicle-stimulating hormone level above 30 IE/l and significantly differ from corresponding parameters in healthy women in peri- and postmenopause.     

The role of the type-III secretion system of Gram-negative bacteria in the regulation of chronic infections

This review article focuses on the discussion about the role of the type III secretion system (T3SS), which was found in several Gram-negative bacteria, in the development of chronic infectious processes. The latest investigations on this issue have revealed that most severe chronic somatic diseases derive from prolonged chronic inflammation induced by various infectious agents. The T3SS may play a crucial role in the transition of an infection from an acute form to persistent one. Numerous clinical and bacteriological studies have shown that pathogenic microorganisms are persistent in a form resistant to various antibiotics. Therefore, one of the most promising goals for the development of novel antibiotics is the T3SS, which transports bacterial pathogenic factors directly into the eukaryotic cell. The functioning of the T3SS is essential for occurrence and development of both acute and chronic infectious processes.     

Preparation and characterization of monoclonal antibodies to group-specific antigenic determinant of group a streptococcus polysaccharide

Group A streptococcus polysaccharide contains at least two different group-specific determinants including N-acetyl-β-D-glucosamine (more important) and rhamnose. Monoclonal antibodies to group-specific determinants of group A streptococcus polysaccharide do not react with tissue antigens. Cross reactions with tissues were detected in tests with monoclonal antibodies to rhamnose-enriched epitopes of group A streptococcus polysaccharide. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 10, pp. 433–436, October, 1999     

Remote results of mini-invasive sympathectomy in chronic arterial insufficiency of extremities

Results of application of miniinvasive desympathization in 42 patients with chronic arterial insufficiency of extremities were analyzed. Clinical and functional dynamic changes of peripheral arterial bed before and after conduction of desympathization in the early, late and remote postoperative period were noted.     

Status of the T- and b-lymphocytes in long-living CBA → F1 (CBA×C57BL/6) chimeras

Semiallogeneic chimeras were obtained by injecting 3 · 10⁷ spleen cells from CBA mice into lethally irradiated F₁(CBA×C57BL/6) mice, into which cyclophosphamide was injected two days later in a dose of 2 mg per mouse. This last procedure prevented death of the recipients from the graft versus host reaction (GVHR). In the course of 1.5–2 months complete chimerism of lymphoid tissue, accompanied by specific areactivity of T-lymphocytes relative to the recipient's transplantation antigens was observed in nearly all recipients. Lymphocytes of the chimeras did not react to C57BL/6 antigens either in a mixed culture of lymphocytes or in the local GVHR and did not destroy C57BL/6 cells in vitro. The serum of the chimeras contained blocking factor, preventing the local GVHR. By the third to fifth month lymphocytes of donor origin were beginning to be replaced by recipient's cells, immunoreactivity to the recipient's transplantation antigens was partially restored, and blocking factor disappeared from the blood of the chimeras.Laboratory of Immunologic Tolerance, N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medial Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR O. V. Baroyan.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 8, pp. 197–200, August, 1978.     

Group A streptococcal polysaccharide inhibits the functional activity of CD8+ supressor cells stimulated with ConA in a human blood mononuclear cell culture

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny., Vol. 115, N ^o 2, pp. 386–389, April, 1993     

Differences in expression of differential activated cell antigen (ACA-1) on T killers and MIF producers

Bulletin of Experimental Biology and Medicine -