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41.
Judy H. Squires Claudia Martinez-Rios James C. Davis Kelly R. Dietz Monica S. Epelman Hollie A. Lai Jennifer E. Lim-Dunham Janice D. McDaniel Joyce C. Mhlanga Neeta Pandit-Taskar Marguerite T. Parisi Andrew T. Trout Elizabeth K. Weidman Adina L. Alazraki 《Pediatric blood & cancer》2023,70(Z4):e29957
Pediatric thyroid cancer is rare in children; however, incidence is increasing. Papillary thyroid cancer and follicular thyroid cancer are the most common subtypes, comprising about 90% and 10% of cases, respectively. This paper provides consensus imaging recommendations for evaluation of pediatric patients with thyroid cancer at diagnosis and during follow-up. 相似文献
42.
New 6-bromoimidazo[1,2-a]pyridine-2-carbohydrazide derivatives: synthesis and anticonvulsant studies
Shrikanth Ulloora Ramakrishna Shabaraya Airody Vasudeva Adhikari 《Medicinal chemistry research》2014,23(6):3019-3028
In the present work, we report the facile synthesis and anticonvulsant study of new imidazo[1,2-a]pyridines carrying biologically active hydrazone functionality (3a–3e) and suitably substituted 1,2,4-triazole moieties (4, 5a–5d, 6, and 7a–7d). The newly synthesized intermediates and final compounds were characterized by various spectral techniques such as FTIR, 1H NMR, 13C NMR, and mass spectral and elemental analysis studies. The in vivo anticonvulsant study of the target compounds were carried out following maximal electroshock seizure and subcutaneous pentylene tetrazole methods, while their toxicity study was performed following rotarod method by taking 20, 40, and 100 mg/kg dose levels. Most of the new compounds displayed remarkable anticonvulsant properties at these doses. Particularly, compounds 3b and 4 carrying hydrogen bond donor groups, viz. hydroxyl and amine moieties respectively, exhibited complete protection against seizure and their results are comparable to that of standard drug diazepam. Further, the motor impairment study revealed that all the compounds are nontoxic upto 100 mg/kg. 相似文献
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Nicholas A. Brasher Anurag Adhikari Andrew R. Lloyd Nicodemus Tedla Rowena A. Bull 《Viruses》2021,13(6)
Despite the advent of effective, curative treatments for hepatitis C virus (HCV), a preventative vaccine remains essential for the global elimination of HCV. It is now clear that the induction of broadly neutralising antibodies (bNAbs) is essential for the rational design of such a vaccine. This review details the current understanding of epitopes on the HCV envelope, characterising the potency, breadth and immunodominance of antibodies induced against these epitopes, as well as describing the interactions between B-cell receptors and HCV infection, with a particular focus on bNAb heavy and light chain variable gene usage. Additionally, we consider the importance of a public repertoire for antibodies against HCV, compiling current knowledge and suggesting that further research in this area may be critical to the rational design of an effective HCV vaccine. 相似文献
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Mammalian oocytes arrest at prophase of meiosis I at around birth and they remain arrested at this stage until puberty when the preovulatory surge of luteinizing hormone (LH) causes ovulation. Prophase I arrest in the immature oocyte results from the maintenance of low activity of maturation promoting factor (MPF), which consists of a catalytic subunit (CDK1) and regulatory subunit (cyclin B1). Phosphorylation-mediated inactivation of CDK1 and constant degradation of cyclin B1 keep MPF activity low during prophase I arrest. LH-mediated signaling manipulates a vast array of molecules to activate CDK1. Active CDK1 not only phosphorylates different meiotic phosphoproteins during the resumption of meiosis but also inhibits their rapid dephosphorylation by inhibiting the activities of CDK1 antagonizing protein phosphatases (PPs). In this way, CDK1 both phosphorylates its substrates and protects them from being dephosphorylated. Accumulating evidence suggests thatthe net MPF activity that drives the resumption of meiosis in oocytes depends on the activation status of CDK1 antagonizing PPs. This review aims to provide a summary of the current understanding of the signaling pathways involved in regulating MPF activity during prophase I arrest and reentry into meiosis of mammalian oocytes. 相似文献
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Ramesh Y. Adhikari Jack Terrell James Targos Kenneth A. Huffman Huihui Wang Joseph Cradlebaugh 《RSC advances》2019,9(47):27289
Electronic waste (e-waste) is a growing problem in the world due to increasing consumption and subsequent discarding of electronic devices. One of the ways to address this problem is to develop electronics made up of biodegradable components. Leaves are readily available, biodegradable and can be found with various types of architecture of the vascular conduits within. We investigated the possibility of developing electronic components based on leaves of a monocotyledon plant by introducing a conducting polymer inside the vascular conduits. We were able to construct conducting wires in those conduits extending to centimeters in length within a leaf. Furthermore, we were able to demonstrate the construction of a supercapacitor within a leaf by using the conducting conduits as electrodes. These results suggest the possibility of constructing embedded electronic components within leaves which may provide an alternative towards the development of biodegradable electronics.Plant leaves were used to construct conducting channels and supercapacitors within. 相似文献
49.
Nirpesh Adhikari Sanjiv Neupane Yam Prasad Aryal Mi Choi Wern‐Joo Sohn Youngkyun Lee Jae‐Kwang Jung Jung‐Hong Ha So‐Young Choi Jo‐Young Suh Ji‐Youn Kim Mun‐Chual Rho Tae‐Hoon Lee Hitoshi Yamamoto Chang‐Hyeon An Sang‐Hyun Kim Seo‐Young An Jae‐Young Kim 《Journal of periodontal research》2019,54(5):533-545
50.
Bansal Anu Jan Iqra Sharma Neeta Raj 《Proceedings of the National Academy of Sciences, India. Section B.》2020,90(5):981-988
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Viruses are causative agents of infections in plants which are found worldwide and cause a serious threat to... 相似文献