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Prevalence of vitamin B12 deficiency in healthy Indian school‐going adolescents from rural and urban localities and its relationship with various anthropometric indices: a cross‐sectional study
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S. Chakraborty M. Chopra K. Mani A. K. Giri P. Banerjee N. S. Sahni A. Siddhu N. Tandon D. Bharadwaj 《Journal of human nutrition and dietetics》2018,31(4):513-522
Background
Micronutrient deficiency is a global health burden, especially among developing countries. The present cross‐sectional study aimed to determine the prevalence of vitamin B12 deficiency in healthy Indian school‐going adolescents, based on area of residence, sex and body mass index (BMI) . Furthermore, the relationship of serum B12 concentration with dietary vitamin B12 intake and anthropometric indices was assessed among adolescents from rural and urban India.Methods
A total of 2403 school‐going adolescents (11–17 years) from National Capital Region and rural areas of Haryana, India were selected. Serum B12 concentrations were estimated using an electrochemiluminescence immunoassay. Dietary assessments were conducted on 65% of total participants (n = 1556) by two 24‐h diet recalls.Results
The prevalence of vitamin B12 deficiency in the total study population was 32.4% (rural: 43.9% versus urban: 30.1%, P < 0.001; male: 34.4% versus female: 31.0%, P < 0.05; normal weight: 28.1%, versus overweight: 39.8%, versus obese: 51.2%, P < 0.001). More than half (51.2%) of obese adolescents were vitamin B12 deficient. On multiple linear regression analysis, serum B12 in rural adolescents was associated with age (β = ?0.12, P < 0.05). Among urban adolescents, serum B12 was associated with BMI (β = ?0.08, P < 0.05) and adjusted dietary vitamin B12 intake (β = 0.14, P < 0.001). Serum vitamin B12 levels were found to be lower in rural females (β = ?0.12, P = 0.030) and urban males (β: 0.11, P < 0.001) compared to their respective contemporaries.Conclusions
Vitamin B12 deficiency was higher among rural school‐going adolescents. Boys had a higher B12 deficiency than girls. Inverse associations of serum B12 with adiposity indices were observed. Serum B12 levels were positively associated with dietary vitamin B12 intake.65.
Bajaj MS Aalok L Gupta V Sen S Pushker N Chandra M 《Journal of clinical ultrasound : JCU》2007,35(8):424-429
PURPOSE: To correlate the ultrasound biomicroscopy (UBM) appearance of eyelid lesions with the results of histopathologic examination. METHODS: Fifty-two patients with eyelid lesions were evaluated using 50-MHz UBM, and the UBM scans were compared with the histopathologic findings. The obscuration of the normal lid sonographic layers and invasion into adjacent tissues were criteria suggesting malignancy. RESULTS: UBM characteristics of different eyelid lesions are presented. The sensitivity of UBM in detecting malignancy ranged from 78% to 86%, whereas the specificity ranged from 37% to 69%. CONCLUSION: This study of eyelid lesions shows that UBM can help differentiate between various benign and malignant lid lesions. 相似文献
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Blassan Samuel Kiran Tummalapalli Prasanth Vuppalapati Giri Madhvesh Pathak 《Medicinal chemistry research》2014,23(2):699-707
A few new and versatile complexes of titanium(IV) derived from 2-hydroxyacetophenone of the types {[(Ap)Ti(OPr i )2?n (L2) n ] (2a, 2e and 2f)}, {[(Ap)Ti(L1OR)(L2)] (2b–2d, 2g–2i)} have been synthesized by the reaction of the precursor [(Ap)Ti(OPr i )2] with different 2-heteroaryl methyl ketone oximes and alkoxyalkanols in various molar ratios in refluxing toluene yielded mono nuclear heteroleptic derivatives, {where, n = 1–2, HAp = 2-hydroxyacetophenone, Pr i = isopropyl, L1 = O–CH2–CH2?, R = CH3, C2H5, C4H9 and HL2=HONC(Me)py-2, HONC(Me)fu-2}. All these newly synthesized complexes were characterized by elemental analysis, mass, UV, FT-IR and NMR (1H, 13C) spectral studies. The mass spectra of the newly synthesized molecules indicate their monomeric state. Spectral studies suggest the bonding between metal and ligands in a tetra coordinated fashion. Thermogravimetric analyses indicate the multistep decomposition of complexes resulting TiO2 as the end product at 600 °C. Antibacterial activities of these complexes were also exercised. Complex 2e is equipotent to the standard drug against Pseudomonas aeruginosa and Escherichia coli. A keen molecular docking study revealed lesser docking scores of some of these complexes than that of the standard drug gentamicin. 相似文献
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Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors 总被引:4,自引:0,他引:4
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