全文获取类型
收费全文 | 572篇 |
免费 | 42篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 33篇 |
妇产科学 | 7篇 |
基础医学 | 62篇 |
口腔科学 | 14篇 |
临床医学 | 58篇 |
内科学 | 140篇 |
皮肤病学 | 12篇 |
神经病学 | 22篇 |
特种医学 | 26篇 |
外科学 | 91篇 |
综合类 | 6篇 |
预防医学 | 46篇 |
眼科学 | 3篇 |
药学 | 53篇 |
中国医学 | 2篇 |
肿瘤学 | 37篇 |
出版年
2024年 | 1篇 |
2023年 | 6篇 |
2022年 | 30篇 |
2021年 | 26篇 |
2020年 | 28篇 |
2019年 | 28篇 |
2018年 | 31篇 |
2017年 | 18篇 |
2016年 | 20篇 |
2015年 | 21篇 |
2014年 | 44篇 |
2013年 | 49篇 |
2012年 | 64篇 |
2011年 | 55篇 |
2010年 | 30篇 |
2009年 | 12篇 |
2008年 | 31篇 |
2007年 | 29篇 |
2006年 | 26篇 |
2005年 | 11篇 |
2004年 | 15篇 |
2003年 | 21篇 |
2002年 | 14篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
排序方式: 共有620条查询结果,搜索用时 15 毫秒
511.
512.
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency 总被引:7,自引:0,他引:7 下载免费PDF全文
Jackson RS Creemers JW Farooqi IS Raffin-Sanson ML Varro A Dockray GJ Holst JJ Brubaker PL Corvol P Polonsky KS Ostrega D Becker KL Bertagna X Hutton JC White A Dattani MT Hussain K Middleton SJ Nicole TM Milla PJ Lindley KJ O'Rahilly S 《The Journal of clinical investigation》2003,112(10):1550-1560
We have previously described the only reported case of human proprotein convertase 1 (PC1) deficiency, in a female (Subject A) with obesity, hypogonadism, hypoadrenalism, and reactive hypoglycemia. We now report the second case of human PC1 deficiency (Subject B), also due to compound heterozygosity for novel missense and nonsense mutations. While both subjects shared the phenotypes of obesity, hypoadrenalism, reactive hypoglycemia, and elevated circulating levels of certain prohormones, the clinical presentation of Subject B was dominated by severe refractory neonatal diarrhea, malabsorptive in type. Subsequent investigation of Subject A revealed marked small-intestinal absorptive dysfunction, which was not previously clinically suspected. We postulate that PC1, presumably in the enteroendocrine cells, is essential for the normal absorptive function of the human small intestine. The differences in the nature and severity of presentation between the two cases cannot readily be explained on the basis of allelic heterogeneity, as the nonsense and missense mutations from both subjects had comparably severe effects on the catalytic activity of PC1. Despite Subject A's negligible PC1 activity, some mature ACTH and glucagon-like peptide 17-36(amide) were detectable in her plasma, suggesting that the production of these hormones, at least in humans, does not have an absolute dependence on PC1. The presence of severe obesity and the absence of growth retardation in both subjects contrast markedly with the phenotype of mice lacking PC1 and suggest that the precise physiological repertoire of this enzyme may vary between mammalian species. 相似文献
513.
Matt Brown Michelle Doherty Morag Robertson Sadaf Shadan Heather Yeomans 《Drug discovery today》2003,8(24):1100-1102
The hottest developments in the fields of cancer research, neuroscience, gene therapy, anti-virals and more, with a pick of the key research papers in these areas. 相似文献
514.
Sadaf S. Arain Tasneem G. Kazi Hassan I. Afridi Farah N. Talpur Atif G. Kazi Kapil D. Brahman 《Nutrition and cancer》2013,65(7):1063-1074
It has been extensively investigated that the chewing of smokeless tobacco (SLT) products may enhance the inflammation of the oral cavity. The aim of the present study is to evaluate the relationship between nickel (Ni) exposure via different SLT products with oral cancer (different sites) incidence in the population of Sindh, Pakistan. The different brands of SLT products (mainpuri, gutkha, and moist snuff) commonly consumed by the studied population were analyzed for Ni contents. The biological samples of oral cancer patients and noncancerous control subjects of both genders, who have or have not consumed SLT products, were collected. The concentration of Ni in biological samples and SLT products were measured by electrothermal atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by using certified reference materials. The results of this study showed that the Ni level was significantly higher in scalp hair and blood samples of oral cancer patients compared to controls (P < 0.01). The study suggested that exposure of Ni as a result of chewing different SLT products may be synergistic with risk factors associated with oral cancer. 相似文献
515.
Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study 下载免费PDF全文
Durga Koteswara Rao Dwaraknath K Murthy Nazia Sultana Shaik Babajan Banaganapalli Kumaraswami Konda Hanmantha P Rao Eswar Ganti Zuhair Ahmed Awan Ashraf A El‐Harouni Ramu Elango Imran Ali Khan Noor Ahmad Shaik 《Clinical and experimental pharmacology & physiology》2017,44(12):1171-1179
The CYP2C8 and CYP2C9 are two major isoforms of the cytochrome P450 enzyme family, which is involved in drug response, detoxification, and disease development. This study describes the differential distribution of amino acid substitution variants of CYP2C8 (*2‐I269F & *3‐R139K) and CYP2C9 (*2‐C144R & *3‐L359A) genes in 234 type 2 diabetes mellitus (T2DM) patients and 218 healthy controls from Andhra Pradesh, South India. Single locus genotype analysis has revealed that homozygous recessive genotypes of 2C8*2‐TT (P ≤ .03), 2C9*2‐TT (P ≤ .02), and heterozygous 2C9*3‐AC (P ≤ .006) are seen to be increasingly present in the case group, indicating a significant level of their association with diabetes in Andhra population. The statistical significance of these recessive genotypes has persisted even under their corresponding allelic forms (P ≤ .01). Genotype association results were further examined by computational protein structure and stability analysis to assess the deleteriousness of the amino acid changes. The mutant CYP 2C8 and 2C9 (both *2 and *3) proteins showed structural drifts at both amino acid residue (range 0.43Å‐0.77Å), and polypeptide chain levels (range 0.68Å‐1.81Å) compared to their wild‐type counterparts. Furthermore, the free energy value differences (range –0.915 to –1.38 Kcal/mol) between mutant and native protein structures suggests the deleterious and destabilizing potential of amino acid substitution polymorphisms of CYP genes. The present study confirms the variable distribution of CYP2C8 (*2 and *3) and CYP2C9 (*2 and *3) allelic polymorphisms among South Indian diabetic populations and further warrants the serious attention of CYP gene family, as a putative locus for disease risk assessment and therapy. 相似文献
516.
Khaliq Asif Amreen Jameel Nazia Krauth Stefanie J. 《Maternal and child health journal》2022,26(7):1442-1452
Maternal and Child Health Journal - Diarrhea is the second leading cause of death especially among children. The age-proportionate mortality of diarrheal disease in infants under 2 years... 相似文献
517.
Zehra Andleeb Choudhary Sadaf Mukarram Mohammad Naeem M. Khan M. Masroor A. Aftab Tariq 《Bulletin of environmental contamination and toxicology》2020,104(5):609-618
Bulletin of Environmental Contamination and Toxicology - The effects of copper (Cu) exposure on growth and physiological characteristics of three genotypes (CN-12, Cim-Sanjeevani and Cim-Arogya) of... 相似文献
518.
519.
Shibata N Kawarai T Meng Y Lee JH Lee HS Wakutani Y Shibata E Pathan N Bi A Sato C Sorbi S Bruni AC Duara R Mayeux R Farrer LA George-Hyslop PS Rogaeva E 《Neurobiology of aging》2007,28(7):1041-1043
The plasmin system is involved in the degradation of Abeta peptides, the accumulation of which in brain is a hallmark of Alzheimer's disease (AD). In a North European case-control AD dataset we studied 14 common variations in the PLG, PAI-1, PLAT and PLI genes encoding components of the plasmin system. Among the four polymorphisms in the PLAT, PAI-1 and PLI genes showing nominally significant evidence for an association with AD (allele p-value=0.01-0.00003) the strongest association was detected for the deletion allele in the Alu-repeat region of the PLAT gene. However, none of these positive results were confirmed in follow-up studies using an independent Canadian case-control cohort and two familial AD datasets of North European and Caribbean Hispanic origin. Thus, the current survey does not support the notion that common polymorphisms in the plasmin genes influence the development of AD. 相似文献
520.