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111.
M. de los Ángeles Leal-Felipe M. del Carmen Arroyo-López M. del Cristo Robayna-Delgado Ana Gómez-Espejo Patricia Perera-Díaz Carmen D. Chinea-Rodríguez Natalia García-Correa Alejandro Jiménez-Sosa 《Australian critical care》2018,31(6):355-361
Background
Hospital-acquired pressure injuries are a costly and largely preventable complication occurring in a variety of acute care settings. Patients admitted to the intensive care unit are at greater risk of developing pressure injuries.Objective
To determine whether the efficiency of scales to measure pressure injury risk increase when a continuously updated 3-day moving average method is used.Methods
With a retrospective cohort design we recruited 3085 patients treated between June 2011 and February 2015 in the intensive care unit of a tertiary level university hospital.The present study included 2777 patients admitted to the Intensive Care Unit of the Hospital Universitario de Canarias, Spain.Patients were evaluated daily with two scales to measure pressure injury risk: the Current Risk Assessment Scale for Pressure injury in Intensive Care scale (EVARUCI scale) and the Conscious level-Mobility-Haemodynamics-Oxygenation-Nutrition Index (COMHON). The moving average was used to create a series of three day averages from the complete time-data set. The moving average method was used to analyze data points by creating series of averages of three days subsets of the time-data set. We calculated the efficiency of the method as the product of positive (PPV) and negative predicted values (NPV) for each scale.Results
The efficiency using the moving average method was: PPV x NPV = 0.483 × 0.907 = 0.438 (standard deviation = 0.059), for EVARUCI Scale, and. PPV x NPV = 0.552 × 0.806 = 0.445 (standard deviation = 0.075) for COMHON Index.Conclusions
The efficiency using the moving average method was higher, than the efficiency of other methods previously reported (0.360 ± 0.009 on average). The present study provides a useful procedure for nurses in clinical practice to assess whether a particular patient is protected against the appearance of pressure injury. The instrument should be used focusing on negative predictive value to indicate protection against pressure injury. 相似文献112.
Sanhita Sinharay Edward A. Randtke Christine M. Howison Natalia A. Ignatenko Mark D. Pagel 《Molecular imaging and biology》2018,20(2):240-248
Purpose
The detection of enzyme activities and evaluation of enzyme inhibitors have been challenging with magnetic resonance imaging (MRI). To address this need, we have developed a diamagnetic, nonmetallic contrast agent and a protocol known as catalyCEST MRI that uses chemical exchange saturation transfer (CEST) to detect enzyme activity as well as enzyme inhibition.Procedures
We synthesized a diamagnetic MRI contrast agent that has enzyme responsive and enzyme unresponsive CEST signals. We tested the ability of this agent to detect the activity of kallikrein 6 (KLK6) in biochemical solutions, in vitro and in vivo, with and without a KLK6 inhibitor.Results
The agent detected KLK6 activity in solution and also detected KLK6 inhibition by antithrombin III. KLK6 activity was detected during in vitro studies with HCT116 colon cancer cells, relative to the detection of almost no activity in a KLK6-knockdown HCT116 cell line and HCT116 cells treated with antithrombin III inhibitor. Finally, strong enzyme activity was detected within an in vivo HCT116 tumor model, while lower enzyme activity was detected in a KLK6 knockdown tumor model and in the HCT116 tumor model treated with antithrombin III inhibitor. In all cases, comparisons of the enzyme responsive and enzyme unresponsive CEST signals were critical for the detection of enzyme activity.Conclusions
This study has established that catalyCEST MRI with an exogenous diaCEST agent can evaluate enzyme activity and inhibition in solution, in vitro and in vivo.113.
Mattia Morri Paolo Chiari Cristiana Forni Antonella Orlandi Magli Domenica Gazineo Natalia Franchini Lorenzo Marconato Tiziana Giamboi Andrea Cotti 《Archives of physical medicine and rehabilitation》2018,99(5):893-899
Objective
To identify the factors associated with recovering autonomy in activities of daily living (ADL) in patients who have had a hip fracture.Design
A prospective cohort study.Setting
The orthopedic and orthogeriatric departments of 2 regional hospitals.Participants
Patients (N=742) aged ≥65 years with a diagnosis of fragility hip fracture.Main Outcome Measures
The level of autonomy at 4 months was assessed using the ADL scale.Results
The median score on the ADL scale at 4 months was 3 (interquartile range, 5). Half of the population was unable to recover their prefracture autonomy levels. The following were found to be risk factors: increasing age (B=.02, P<.001); an elevated number of comorbidities (B=.044, P=.005); a lower level of prefracture autonomy (B=.087, P<.001); more frequent use of an antidecubitus mattress (B=.211, P<.001); an increased number of days with disorientation (B=.002, P=.012); failure to recover deambulation (B=.199, P<.001); an increased number of days with diapers (B=.003, P<.001), with a urinary catheter (B=.03, P<.001), and with bed rails (B=.001, P=.014); and a nonintensive care pathway (B=.199, P=.014).Conclusions
Recovery of deambulation, treatment of disorientation and management of incontinence are modifiable factors significantly associated with the functional recovery of autonomy. 相似文献114.
115.
Olga Ivanitskaya MD PhD Elena Andreeva MD PhD Natalia Odegova MD 《Journal of ultrasound in medicine》2018,37(4):1039-1042
A ventricular septal aneurysm is a rare heart defect located in the muscular or membranous part of the septum. Muscular ventricular septal aneurysms are usually isolated, with a favorable prognosis. Membranous ventricular septal aneurysms are often associated with other heart anomalies, could result in serious complications, and may require surgical treatment. We describe 2 cases of prenatally diagnosed ventricular septal aneurysms: an isolated membranous ventricular septal aneurysm with a good outcome, which was initially misdiagnosed as an atrioventricular septal defect; and a muscular ventricular septal aneurysm associated with a hypoplastic aortic arch and severe hydrocephaly, which resulted in termination of the pregnancy. To our knowledge, the combination of a muscular ventricular septal aneurysm with an extracardiac anomaly has not been reported previously. 相似文献
116.
Effectiveness of an intensive intervention to improve lifestyles in people with intermediate cardiovascular risk (DATE study): Study protocol for a randomized controlled trial 下载免费PDF全文
117.
118.
Azpiri-Lopez Jose R. Galarza-Delgado Dionicio A. Colunga-Pedraza Iris J. Arvizu-Rivera Rosa I. Cardenas-de la Garza Jesus A. Vera-Pineda Raymundo Davila-Jimenez Jose A. Martinez-Flores Carolina M. Rodriguez-Romero Alejandra B. Guajardo-Jauregui Natalia 《Clinical rheumatology》2021,40(7):2651-2656
Clinical Rheumatology - Rheumatoid arthritis (RA) patients are at increased risk for developing cardiovascular disease, including right heart failure. The evaluation of right ventricle (RV) using... 相似文献
119.
Ferraz Ana Paula Seara Fernando A. C. Baptista Emanuelle F. Barenco Thais S. Sottani Thais B. B. Souza Natalia S. C. Domingos Ainá E. Barbosa Raiana A. Q. Takiya Christina M. Couto Marcos T. Resende Gabriel O. Campos de Carvalho Antonio C. Ponte Cristiano G. Nascimento Jose Hamilton M. 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2021,35(4):719-732
Cardiovascular Drugs and Therapy - In the present study, the therapeutic efficacy of a selective BKCa channel opener (compound X) in the treatment of monocrotaline (MCT)-induced pulmonary arterial... 相似文献
120.
Mena-Vázquez Natalia Jimenez-Núñez Francisco Gabriel Godoy-Navarrete Francisco Javier Manrique-Arija Sara Aguilar-Hurtado María Carmen Romero-Barco Carmen María Ureña-Garnica Inmaculada Espildora F. Padin-Martín María Isabel Fernández-Nebro Antonio 《Clinical rheumatology》2021,40(6):2377-2385
Clinical Rheumatology - To analyze the diagnostic utility of lung ultrasound (US) to detect interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients comparing with high-resolution... 相似文献