全文获取类型
收费全文 | 1048篇 |
免费 | 90篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 44篇 |
妇产科学 | 120篇 |
基础医学 | 117篇 |
口腔科学 | 58篇 |
临床医学 | 90篇 |
内科学 | 203篇 |
皮肤病学 | 20篇 |
神经病学 | 34篇 |
特种医学 | 31篇 |
外科学 | 151篇 |
综合类 | 34篇 |
预防医学 | 72篇 |
眼科学 | 30篇 |
药学 | 67篇 |
中国医学 | 1篇 |
肿瘤学 | 46篇 |
出版年
2023年 | 11篇 |
2022年 | 30篇 |
2021年 | 50篇 |
2020年 | 12篇 |
2019年 | 18篇 |
2018年 | 32篇 |
2017年 | 18篇 |
2016年 | 33篇 |
2015年 | 37篇 |
2014年 | 29篇 |
2013年 | 39篇 |
2012年 | 73篇 |
2011年 | 58篇 |
2010年 | 40篇 |
2009年 | 44篇 |
2008年 | 67篇 |
2007年 | 58篇 |
2006年 | 50篇 |
2005年 | 45篇 |
2004年 | 51篇 |
2003年 | 32篇 |
2002年 | 42篇 |
2001年 | 22篇 |
2000年 | 24篇 |
1999年 | 22篇 |
1998年 | 8篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 8篇 |
1993年 | 4篇 |
1992年 | 12篇 |
1991年 | 12篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 14篇 |
1987年 | 10篇 |
1986年 | 7篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1974年 | 11篇 |
1973年 | 12篇 |
1972年 | 5篇 |
1971年 | 5篇 |
1969年 | 6篇 |
排序方式: 共有1143条查询结果,搜索用时 10 毫秒
91.
Abdulla Ibrahim Mahmoud K. Nassar Daniel J. Jordan Manish Sinha Fiona J. Hogg 《Journal of plastic, reconstructive & aesthetic surgery》2018,71(8):1174-1180
The Adult Exceptional Aesthetic Referral Protocol (AEARP) encompasses a series of aesthetic procedures which, as they do not treat an underlying disease process, are not routinely available within the National Health Service. Provision of these services can only be provided on an exceptional basis.In this prospective study, we evaluated the referral process and outcomes of 1122 patients referred under the AEARP over a 3.5-year period. Referrals were screened by a vetting panel comprising of a plastic surgeon, clinical nurse specialist, and clinical psychologist. Following initial vetting, supported patients underwent psychological assessment. Patients supported by psychology were assessed in clinic, and if deemed clinically suitable, were offered surgery.Overall, 20% (225/1122) of referrals were supported for surgery. Following primary vetting, 57% (640/1,122) of referrals were supported, 40% (197/492) of referrals to clinical psychology were supported, and 65% (225/345) of the remaining cases referred for consultation were supported for surgery. Unsupported referrals included those not fulfilling the referral guidelines or those with contraindications.The AEARP is simple and effective to implement, and has been instrumental in streamlining the referral-to-outcome process in a centralised, transparent, and fair manner. It reduces a potential high number of clinic appointments where patients do not meet the aesthetic criteria and/or fail to attend – thereby helping to streamline other surgical pathways by improving clinic efficiency. Moreover, it aids referring clinicians and patient education around aesthetic issues including a holistic approach. Wide adoption of such standards may reduce waiting times, facilitate cost savings, and ultimately enhance patient outcomes. 相似文献
92.
93.
94.
95.
Jimenez JJ Iribarren JL Lorente L Rodriguez JM Hernandez D Nassar I Perez R Brouard M Milena A Martinez R Mora ML 《Critical care (London, England)》2007,11(6):R117-10
Introduction
Extracorporeal circulation induces hemostatic alterations that lead to inflammatory response (IR) and postoperative bleeding. Tranexamic acid (TA) reduces fibrinolysis and blood loss after cardiopulmonary bypass (CPB). However, its effects on IR and vasoplegic shock (VS) are not well known and elucidating these effects was the main objective of this study.Methods
A case control study was carried out to determine factors associated with IR after CPB. Patients undergoing elective CPB surgery were randomly assigned to receive 2 g of TA or placebo (0.9% saline) before and after intervention. We performed an intention-to-treat analysis, comparing the incidence of IR and VS. We also analyzed several biological parameters related to inflammation, coagulation, and fibrinolysis systems. We used SPSS version 12.2 for statistical purposes.Results
In the case control study, 165 patients were studied, 20.6% fulfilled IR criteria, and the use of TA proved to be an independent protective variable (odds ratio 0.38, 95% confidence interval 0.18 to 0.81; P < 0.01). The clinical trial was interrupted. Fifty patients were randomly assigned to receive TA (24) or placebo (26). Incidence of IR was 17% in the TA group versus 42% in the placebo group (P = 0.047). In the TA group, we observed a significant reduction in the incidence of VS (P = 0.003), the use of norepinephrine (P = 0.029), and time on mechanical ventilation (P = 0.018). These patients showed significantly lower D-dimer, plasminogen activator inhibitor 1, and creatine-kinase levels and a trend toward lower levels of soluble tumor necrosis factor receptor and interleukin-6 within the first 24 hours after CPB.Conclusion
The use of TA attenuates the development of IR and VS after CPB.Trial registration number
ISRCTN05718824. 相似文献96.
B. Dawson-Hughes A. Mithal J.-P. Bonjour S. Boonen P. Burckhardt G. E.-H. Fuleihan R. G. Josse P. Lips J. Morales-Torres N. Yoshimura 《Osteoporosis international》2010,21(7):1151-1154
This position paper of the International Osteoporosis Foundation makes recommendations for vitamin D nutrition in elderly
men and women from an evidence-based perspective. 相似文献
97.
Zheng Guo Alvin Chen Roger A. Nassar Bernhard Helk Claudia Mueller Yu Tang Kapil Gupta Alexander M. Klibanov 《Pharmaceutical research》2012,29(11):3102-3109
Purpose
To discover, elucidate the structure-activity relationship (SAR), and explore the mechanism of action of excipients able to drastically lower the viscosities of concentrated aqueous solutions of humanized monoclonal antibodies (MAbs).Methods
Salts prepared from hydrophobic cations and anions were dissolved into humanized MAbs solutions. Viscosities of the resulting solutions were measured as a function of the nature and concentration of the salts and MAbs.Results
Even at moderate concentrations, some of the salts prepared herein were found to reduce over 10-fold the viscosities of concentrated aqueous solutions of several MAbs at room temperature.Conclusions
To be potent viscosity-lowering excipients, the ionic constituents of the salts must be hydrophobic, bulky, and aliphatic. A mechanistic hypothesis explaining the observed salt effects on MAb solutions’ viscosities was proposed and verified. 相似文献98.
Nassar A Cohen C Agersborg SS Zhou W Lynch KA Barker EA Vanderbilt BL Thompson J Heyman ER Olson A Lange H Siddiqui MT 《American journal of clinical pathology》2011,135(3):461-467
A multisite study was conducted to assess the performance of the Aperio digital pathology system (Aperio Technologies, Vista, CA) for reading estrogen receptor (ER) and progesterone receptor (PR) slides on a computer monitor. A total of 520 formalin-fixed breast tissue specimens were assayed at 3 clinical sites for ER and PR (260 each). Percentage and average staining intensity of positive nuclei were assessed. At each site, 3 pathologists performed a blinded reading of the glass slides using their microscopes initially and later using digital images on a computer monitor. Comparable percentages of agreements were obtained for manual microscopy (MM) and manual digital slide reading (MDR) (ER, percentage of positive nuclei with cutoffs: MM, 91.3%-99.0%/MDR, 91.3%-100.0%; PR, percentage of positive nuclei with cutoffs: MM, 83.8%-99.0%/MDR, 76.3%-100.0%). Reading ER and PR slides on a computer monitor using the Aperio digital pathology system is equivalent to reading the slides with a conventional light microscope. 相似文献
99.
Particular systemic infections have been found to be associated with concurrent malignancies sufficiently commonly as to warrant search for malignancy in patients with such infections. The current study adds Streptococcus pneumonia endocarditis to the list of relevant infections. 相似文献
100.
Fornari LS Calderaro D Nassar IB Lauretti C Nakamura L Bagnatori R Ageno W Caramelli B 《Journal of thrombosis and thrombolysis》2007,23(1):65-71
Purpose To assess the use of antithrombotic therapy among atrial fibrillation (AF) patients in a Brazilian University Heart Hospital
(InCor).
Methods and results In a cross-sectional study we analyzed the charts of all patients treated at InCor in five separate days of 2002 (Phase 1).
To assess the impact of admission to a cardiology hospital, a follow-up of the AF patients selected in Phase 1 was carried
out after 1 year (Phase 2). The prevalence of AF in the 3,764 assessed charts was 8.0% (301 patients). In Phase 1, antiplatelets
were prescribed to 21.2% and anticoagulant therapy (ACT) to 46.5% of AF patients; in Phase 2, to 19.9 and 57.8%, respectively.
Thus, 32.2% (Phase 1) and 22.2% (Phase 2) of AF patients were not receiving any antithrombotic drug. Among AF patients with
previous ischemic stroke (17.6%), only 49% (Phase 1) and 60.4% (Phase 2) were receiving ACT. As many as 34 and 22.6%, respectively,
were not receiving any antithrombotic drug. After follow-up, a new acute embolic event was documented in 5.6% of patients,
17% died.
Conclusions Anticoagulation is underused in AF patients and neither the fact of being treated by cardiologists in a University Hospital,
nor the learning time-window of 1 year seemed to improve the antithrombotic care significantly. 相似文献