全文获取类型
收费全文 | 3188篇 |
免费 | 138篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 41篇 |
妇产科学 | 21篇 |
基础医学 | 417篇 |
口腔科学 | 134篇 |
临床医学 | 182篇 |
内科学 | 783篇 |
皮肤病学 | 22篇 |
神经病学 | 124篇 |
特种医学 | 112篇 |
外科学 | 748篇 |
综合类 | 8篇 |
预防医学 | 101篇 |
眼科学 | 37篇 |
药学 | 188篇 |
中国医学 | 4篇 |
肿瘤学 | 371篇 |
出版年
2023年 | 10篇 |
2022年 | 31篇 |
2021年 | 67篇 |
2020年 | 23篇 |
2019年 | 31篇 |
2018年 | 63篇 |
2017年 | 54篇 |
2016年 | 40篇 |
2015年 | 64篇 |
2014年 | 95篇 |
2013年 | 109篇 |
2012年 | 174篇 |
2011年 | 211篇 |
2010年 | 117篇 |
2009年 | 120篇 |
2008年 | 185篇 |
2007年 | 221篇 |
2006年 | 215篇 |
2005年 | 250篇 |
2004年 | 212篇 |
2003年 | 201篇 |
2002年 | 201篇 |
2001年 | 60篇 |
2000年 | 44篇 |
1999年 | 51篇 |
1998年 | 37篇 |
1997年 | 37篇 |
1996年 | 29篇 |
1995年 | 17篇 |
1994年 | 27篇 |
1993年 | 18篇 |
1992年 | 27篇 |
1991年 | 22篇 |
1990年 | 24篇 |
1989年 | 34篇 |
1988年 | 34篇 |
1987年 | 19篇 |
1986年 | 19篇 |
1985年 | 20篇 |
1984年 | 19篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 11篇 |
1980年 | 13篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1975年 | 7篇 |
1972年 | 8篇 |
1971年 | 5篇 |
1970年 | 5篇 |
排序方式: 共有3342条查询结果,搜索用时 15 毫秒
21.
Shigeyuki Kitamura Tomoharu Suzuki Tomoko Kadota Mayumi Yoshida Koji Ohashi Shigeru Ohta 《Drug metabolism and disposition》2003,31(2):179-186
The in vitro metabolism of fenthion and its sulfoxide (fenthion sulfoxide) in sea bream (Pagrus major) and goldfish (Carassius auratus) was investigated and compared with that in rats. Fenthion was oxidized to fenthion sulfoxide and the oxon derivative, but not to its sulfone, in the presence of NADPH by liver microsomes of sea bream, goldfish, and rats. These liver microsomal activities of the fish were lower than those of rats but were of the same order of magnitude. The NADPH-linked oxon- and sulfoxide-forming activities of liver microsomes of the fish and rats were inhibited by SKF 525-A, metyrapone, alpha-naphthoflavone, and carbon monoxide. The oxidizing activity to fenthion sulfoxide was also inhibited by alpha-naphthylthiourea. Several cytochrome P450 isoforms and flavin-containing monooxygenase 1 exhibited these oxidase activities. Fenthion sulfoxide was reduced to fenthion with liver cytosol of the fish and rats upon addition of 2-hydroxypyrimidine, N(1)-methylnicotinamide, or butyraldehyde, each of which is an electron donor of aldehyde oxidase, under anaerobic conditions. The activity was inhibited by menadione, beta-estradiol, and chlorpromazine, which are inhibitors of aldehyde oxidase. The activities in the fish livers were similar to those of rat liver. Aldehyde oxidase purified from the livers of sea bream and rats exhibited the reducing activity. Thus, fenthion and fenthion sulfoxide are interconvertible in fish and rats through the activities of cytochrome P450, flavin-containing monooxygenase, and aldehyde oxidase. 相似文献
22.
Yoichi Kohno Shigeyuki Kitamura Seigo Sanoh Kazumi Sugihara Nariaki Fujimoto Shigeru Ohta 《Drug metabolism and disposition》2005,33(8):1115-1123
When chalcone and trans-4-phenyl-3-buten-2-one (PBO) were incubated with liver microsomes of untreated rats in the presence of NADPH, 4-hydroxychalcone and trans-4-(4-hydroxyphenyl)-3-buten-2-one (4-OH-PBO), respectively, were formed as major metabolites. Two minor metabolites of chalcone, 4'-hydroxychalcone and 2-hydroxychalcone, were also observed. The oxidase activity affording 4-hydroxychalcone was inhibited by SKF 525-A, disulfiram, ketoconazole, and alpha-naphthoflavone. The oxidase activities leading to 4-hydroxychalcone and 4'-hydroxychalcone were enhanced in liver microsomes of 3-methylcholanthrene- and phenobarbital-treated rats, respectively. The activity generating 2-hydroxychalcone was enhanced in liver microsomes of 3-methylcholanthrene- and dexamethasone-treated rats. The oxidation of PBO to 4-OH-PBO was inhibited by SKF 525-A, ketoconazole, disulfiram, and sulfaphenazole. This activity was enhanced in liver microsomes of 3-methylcholanthrene-, acetone- and phenobarbital-treated rats. 4-Hydroxylation, 4'-hydroxylation, and 2-hydroxylation of chalcone were catalyzed by rat recombinant cytochrome P450 1A1, 1A2, and 2C6; by 1A1 and 2C6; and by 1A1 and 3A1, respectively. PBO was oxidized by cytochrome P450 1A1, 1A2, 2C6, and 2E1. Chalcone and PBO were negative in an estrogen reporter assay using estrogen-responsive human breast cancer cell line MCF-7. However, 4-hydroxychalcone, 2-hydroxychalcone, 4'-hydroxychalcone, and 4-OH-PBO exhibited estrogenic activity. 相似文献
23.
Shinichiro Asakawa Shigeyuki Arai Mika Kawagoe Chiaki Ohata Wataru Ono Hiroshi Murata Yoshifuru Tamura Shunya Uchida Shigeru Shibata Yoshihide Fujigaki 《Internal medicine (Tokyo, Japan)》2022,61(9):1423
A young woman with microscopic polyangiitis (MPA) requiring hemodialysis showed repeated posterior reversible encephalopathy syndrome (PRES) with spatiotemporal multiple lesions over a period of two months. The first PRES episode with confusion and the second PRES episode with vertigo and nausea were caused by MPA, hypertension and renal failure. These symptoms were improved by the reinforcement of MPA treatment and blood pressure management. The third PRES episode with nausea, headache, seizure and visual changes was induced by rituximab infusion and hypertension. The PRES was improved with blood pressure and convulsant management. These conditions are challenging to diagnose and treat. 相似文献
24.
Murata T Miyase T Muregi FW Naoshima-Ishibashi Y Umehara K Warashina T Kanou S Mkoji GM Terada M Ishih A 《Journal of natural products》2008,71(2):167-174
From the stem bark of Ekebergia capensis, 10 new triterpenoid compounds, ekeberins A (1), B (2), C1 (3), C2 (4), C3 (5), D1 (6), D2 (7), D3 (8), D4 (9), and D5 (10), were isolated together with 17 known compounds. The structures of these new compounds were elucidated on the basis of the results of spectroscopic analysis, and the absolute configuration of compounds 6-10 were determined by partial synthesis from known compounds and using the Mosher ester method. Several of these compounds were screened in vitro against both chloroquine (CQ)-sensitive and -resistant Plasmodium falciparum isolates and were found to exhibit moderate antiplasmodial activity, with compounds 20 (7-deacetoxy-7-oxogedunin) and 27 (2-hydroxymethyl-2,3,22,23-tetrahydroxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene) showing IC50 values of 6 and 7 microM, respectively. Compound 27 at a dose of 500 mg/kg showed moderate parasitemia suppression of 52.9% against P. berghei NK 65 in a mouse model. 相似文献
25.
Toshiyuki Uesaka Tomoyuki Ishitani Takahito Shimeno Naoya Suzuki Shigeyuki Yagi Takeshi Maeda 《RSC advances》2022,12(27):17350
We developed a series of blue-emitting 1,8-naphthalimide dyes covalently attached to 2-(2-hydroxyphenyl)-2H-benzotriazoles that retard photodegradation of the fluorophore. The dyes displayed weaker fluorescence emissions than the parent 1.8-naphthalimide. Quantum chemical calculations suggested that the decreased fluorescence was caused by the nonradiative deactivation promoted through the excited state intramolecular proton transfer (ESIPT) in benzotriazole components. The dyes'' phosphorescences in a degassed solution at 77 K were more efficient than that of the parent 1.8-naphthalimide, indicating a possible deactivation pathway through intersystem crossing. PMMA films doped with these dyes showed higher resistance against photoaging than the film doped with an equimolar mixture of constituent 1.8-naphthalimide and the benzotriazole derivatives. Thus, the covalently linked benzotriazole units slow fluorophore degradation not only by preferential absorption of harmful UV light, which is found in the film with a simple mixture of two components, but also by the nonradiative deactivation involved in benzotriazole units.Highly photostable blue fluorescence dyes were developed by hybridization of 1,8-naphthalimides with benzotriazole-based UV absorbers enabling a non-radiative energy dissipation process of excited-state intramolecular proton transfer (ESIPT). 相似文献
26.
Trends in dietary fiber intake in Japan over the last century 总被引:5,自引:0,他引:5
Nakaji S Sugawara K Saito D Yoshioka Y MacAuley D Bradley T Kernohan G Baxter D 《European journal of nutrition》2002,41(5):222-227
Summary. Background: Insufficient intake of dietary fiber (DF) is currently a major problem in the overall promotion of health in the general
population in Japan. Aim of the study: To analyze the time trends in DF intake, including DF density (total DF intake/1,000 kcal), and the ratio of water-insoluble
fiber to water-soluble fiber (IS ratio) in Japan. Methods: The time trend in DF intake in Japan was calculated from data compiled in the Japanese National Nutrition Survey. Results: The mean daily DF intake (total DF intake) in 1952 was 20.5 g/day, which rapidly declined to about 70 % of the 1952 level
in 1970, after which there was little change to 1998. DF density in 1952 was 9.7 g/1000 kcal, which declined by about 30 %
in 1970, and remained at about the same level to 1998. The IS ratio has remained stable over this period. Whereas total DF
intake and DF density in Japan are similar to those in Western countries, the IS ratios are higher in Japan. Therefore, the
higher incidence of, and mortality from, colon diverticulosis, coronary heart disease, hyperlipidemia, etc., which are all
thought to be related to fiber deficiency, in Western countries compared to Japan might be due to the differences in the IS
ratio. Conclusions: A decline in total DF intake and DF density is predicted for Japan in the future, because these parameters were lower among
the younger generation. This may be due to the marked changes in the dietary habits of the younger generation, and is a problematic
trend for Japanese health.
Received: 26 April 2002, Accepted: 22 August 2002
Correspondence to: Shigeyuki Nakaji, MD, PhD 相似文献
27.
28.
29.
Shigeyuki Ebara Mikio Marumo Jun Mukai Makoto Ohki Kagehiro Uchida Ichiro Wakabayashi 《Journal of thrombosis and thrombolysis》2018,45(2):200-205
Although oxidization of LDL is known to be a crucial step for atherosclerotic progression, the significance of oxidized HDL remains to be clarified. The purpose of this study was to determine the relationships of oxidized HDL with blood coagulation and fibrinolysis in patients with diabetes. The subjects were outpatients with type 2 diabetes (n?=?163; median hemoglobin A1c, 6.9%). Activities of blood coagulation and fibrinolysis were evaluated by levels of thrombin–anti-thrombin complex (TAT) and plasmin–α2 plasmin inhibitor complex (PIC), respectively. Relationships of oxidized HDL with TAT and PIC were investigated by using linear regression analysis and logistic regression analysis. Oxidized HDL showed a significant inverse correlation with TAT and a marginally significant correlation with PIC (Spearman’s rank correlation coefficient: TAT, ??0.205 [p?<?0.01]; PIC, ??0.135 [p?=?0.087]). Prevalence of high TAT was significantly lower in the 3rd tertile group for oxidized HDL than in its 1st tertile (20.4 vs. 5.6%, p?<?0.05), and prevalence of high PIC was marginally significantly lower in the 3rd tertile group for oxidized HDL than in its 1st tertile (40.7 vs. 24.1%, p?=?0.099). In multivariate logistic regression analysis using age, gender, smoking, alcohol drinking, BMI, hemoglobin A1c, therapy for dyslipidemia, therapy for diabetes and anti-coagulation therapy as explanatory variables, odds ratios for high TAT and high PIC in the 3rd tertile group for oxidized HDL versus its 1st tertile group were significantly lower than the reference level of 1.00 (high TAT: 0.19 [0.04–0.99], p?<?0.05; high PIC: 0.33 [0.12–0.95], p?<?0.05). The frequency of high TAT or high PIC was lower in the higher tertile group for oxidized HDL than in its lower tertile group. Thus, oxidized HDL is thought to be inversely associated with both blood coagulation and fibrinolysis in patients with type 2 diabetes. 相似文献
30.
Yamagishi H Koike T Ohara S Kobayashi S Ariizumi K Abe Y Iijima K Imatani A Inomata Y Kato K Shibuya D Aida S Shimosegawa T 《World journal of gastroenterology : WJG》2008,14(9):1358-1364
AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan.
METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged 〉 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period.
RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients.
CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group. 相似文献
METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged 〉 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period.
RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients.
CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group. 相似文献