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排序方式: 共有496条查询结果,搜索用时 15 毫秒
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Trenaman Logan Munro Sarah Almeida Fernanda Ayas Najib Hicklin James Bansback Nick 《Sleep & breathing》2016,20(2):653-661
Sleep and Breathing - To describe the development and assess the usability of a patient decision aid (PtDA) prototype designed for newly diagnosed, treatment-naïve, obstructive sleep apnea... 相似文献
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Jadwiga Najib Ekaterina Didenko Daria Meleshkina Kamila Yusupov Kateryna Maw Justin Ramnarain 《Current medical research and opinion》2020,36(10):1717-1735
Abstract
Objective
Lisdexamfetamine dimesylate is a stimulant prodrug with low abuse and diversion potential that is used in treatment of attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults. This current literature review article aims to examine safety and efficacy of LDX in children and adolescents for the treatment of ADHD based on currently available data. 相似文献84.
Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humans 总被引:6,自引:0,他引:6
Sarah-Jane C. Lusina Paul M. Kennedy J. Timothy Inglis Donald C. McKenzie Najib T. Ayas A. William Sheel 《The Journal of physiology》2006,575(3):961-970
We determined the effects of 10 daily exposures of intermittent hypoxia (IH; 1 h day−1 ; oxyhaemoglobin saturation = 80%) on muscle sympathetic nerve activity (MSNA, peroneal nerve) and the hypoxic ventilatory response (HVR) before, during and after an acute 20 min isocapnic hypoxic exposure. We also assessed the potential parallel modulation of the ventilatory and sympathetic systems following IH. Healthy young men ( n = 11; 25 ± 1 years) served as subjects and pre- and post-IH measures of MSNA were obtained on six subjects. The IH intervention caused HVR to significantly increase (pre-IH = 0.30 ± 0.03; post-IH = 0.61 ± 0.12 l min−1 % S aO2 −1 ) . During the 20 min hypoxic exposure sympathetic activity was significantly greater than baseline and remained above baseline after withdrawal of the hypoxic stimulus, even though oxyhaemoglobin saturation had normalized and ventilation and blood pressure had returned to baseline levels. When compared to the pre-IH trial, burst frequency increased ( P < 0.01), total MSNA trended towards higher values ( P = 0.06), and there was no effect on burst amplitude ( P = 0.82) during the post-IH trial. Following IH the rise in MSNA burst frequency was strongly related to the change in HVR ( r = 0.79, P < 0.05) suggesting that these sympathetic and ventilatory responses may have common central control. 相似文献
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目的:探讨和验证前列痛栓治疗前列腺痛的药效。方法:采用小鼠肛门给药,以空白,消炎痛栓为对照组。测定前列痛栓对小鼠扭体次数,网状内皮系统吞噬指数,耳廓肿胀,肉芽增生及大鼠小肠肌电的影响。结果:前列痛栓能明显减少小鼠扭体次数,优于消炎痛栓;对网状内皮系统吞噬功能,二甲苯所致小鼠耳廓肿胀和滤纸片埋入形成的肉芽增生及大鼠小肠肌电的影响。与消炎痛栓相近。结论:前列痛栓治疗前列腺痛有显著的镇痛作用。 相似文献
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Ganiou Tidjani K Ailal F Najib J Bellanné-Chantelot C Donadieu J Bousfiha AA 《Pediatric blood & cancer》2008,51(5):701-703
A 12-year-old daughter of consanguineous Moroccan parents was diagnosed with cyclic neutropenia, based on a combination of recurrent gingivostomatitis, a fluctuating neutrophil count, and several episodes of severe neutropenia. No ELA2 gene mutations were found. At age 19 years she presented with edema of the limbs, proteinuria and renal failure. Renal amyloidosis AA was diagnosed by biopsy. Gene mutations associated with family Mediterranean fever (FMF) were sought, and a homozygous mutation (M694V) was found in the MFEV gene. This is the novel finding of FMF that masqueraded as cyclic neutropenia. 相似文献