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71.
72.
Elham Barkhordari Nima Rezaei Bita Ansaripour Pegah Larki Maryam Alighardashi Hamid Reza Ahmadi-Ashtiani Mahdi Mahmoudi Mohammad-Reza Keramati Peiman Habibollahi Mohammad Bashashati Naser Ebrahimi-Daryani Ali Akbar Amirzargar 《Journal of clinical immunology》2010,30(1):74-79
Introduction
Irritable bowel syndrome (IBS) is a multifactorial functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. Proinflammatory cytokines can play an important role in intestinal inflammation, while their production is under genetic control.Methods
This study was performed in a group of patients with IBS to analyze the genotype frequencies of a number polymorphic genes coding for proinflammatory cytokine (interleukin-6 (IL), tumor necrosis factor-alpha (TNF-α), and IL-1 group). Using polymerase chain reaction with sequence-specific primers method, the cytokine genes were amplified, and alleles and genotypes of 71 patients with IBS were detected on gel electrophoresis, and the results were compared with healthy control subjects.Results
Results of the analyzed data showed that the frequencies IL-1R C allele at position Pst-I 1970 (P?=?0.017), IL-6 G allele at position ?174 (P?=?0.002), and TNF-α G allele at position ?238 (P?<?0.001) in the patient group were significantly higher than the control group. IL-6 GG genotype (?174) and TNF-α GG genotype (?238) in the patient group were also significantly overrepresented (P?<?0.001), while IL-6 CG genotype (?174) and TNF-α GA genotype (?238) were significantly decreased in the patients with IBS (P?<?0.001). The frequencies of IL-6 (?174, nt565) GG haplotype and TNF-α (?308, ?238) GG haplotype were also significantly higher in the patient group (P?<?0.001), whereas the frequencies of the haplotypes IL-6 CG and TNF-α GA were significantly decreased in the patients with IBS (P?<?0.001).Conclusion
IL-6 and TNF-alpha proinflammatory cytokine gene polymorphisms could change individual susceptibility to IBS and might have a role in pathophysiology of disease. 相似文献73.
Hussein Daoud Mahdi Ghani Landry Nfonsam Ryan Potter Shelley Ordorica Virginia Haslett Nathaniel Santos Heather Derksen Donelda Lahey Martha McGill Vanessa Trudel Brittany Antoniuk Nasim Vasli Caitlin Chisholm Gabrielle Mettler Elizabeth Sinclair-Bourque Jean McGowan-Jordan Amanda Smith Olga Jarinova 《The Journal of molecular diagnostics : JMD》2019,21(3):437-448
74.
Elham Barkhordari Nima Rezaei Mahdi Mahmoudi Pegah Larki Hamid Reza Ahmadi-Ashtiani Bita Ansaripour Maryam Alighardashi Mohammad Bashashati Ali Akbar Amirzargar Naser Ebrahimi-Daryani 《Inflammation》2010,33(5):281-286
Inflammation and mucosal immune system activation have an important role in irritable bowel syndrome (IBS), whereas genetic
factors can control some immunological mediators. In this study, a number of polymorphic genes coding for T-helper 1, T-helper
2, and T-regulatory cytokines were genotyped in 71 patients with IBS, and the results were compared with controls. IL-4 CC
genotype at position −590, IL-4 TT genotype at position −33, and IL-10 GA genotype at position −1082 were significantly overrepresented
in the patients with IBS in comparison with controls (P < 0.001). The frequencies of the following haplotypes in the patient group were significantly higher than in the control
group: IL-2 (−330, +160) GT haplotype (P = 0.002), IL-4 (−1098, −590, −33) TCC haplotype (P < 0.001), and TCT haplotype (P < 0.001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of
cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS. 相似文献
75.
76.
The conditioning context arises from the relatively static features of the training environment. In rabbit eyeblink conditioning, procedures that retard acquisition (conditioned stimulus [CS] preexposure, unconditioned stimulus preexposure, blocking manipulations) are attenuated by context changes. In this article the authors investigate the effect of context exposure after initial delay conditioning. After conditioned responses (CRs) were established, one group received 6 sessions of context exposure, whereas control groups either remained in their home cages or received exposure to handling and a novel context. Thereafter, all groups received CS-alone testing. The expression of CRs was substantially reduced following context exposure relative to any retention loss in the home-cage control. Exposure to handling and a novel context facilitated the CRs rather than reducing them. ((c) 2006 APA, all rights reserved). 相似文献
77.
Elsheikha HM Murphy AJ Fitzgerald SD Mansfield LS Massey JP Saeed MA 《Parasitology research》2003,90(2):104-109
This report describes a new, inexpensive procedure for the rapid and efficient purification of Sarcocystis neurona sporocysts from opossum small intestine. S. neurona sporocysts were purified using a discontinuous potassium bromide density gradient. The procedure provides a source of sporocyst wall and sporozoites required for reliable biochemical characterization and for immunological studies directed at characterizing antigens responsible for immunological responses by the host. The examined isolates were identified as S. neurona using random amplified polymorphic DNA primers and restriction endonuclease digestion assays. This method allows the collection of large numbers of highly purified S. neurona sporocysts without loss of sporocyst viability as indicated by propidium iodide permeability and cell culture infectivity assays. In addition, this technique might also be used for sporocyst purification of other Sarcocystis spp. 相似文献
78.
Indeterminate genotypes of hepatitis C virus by the Abbott RealTime HCV Genotype II assay in Morocco. About eight cases resolved by a sequencing method 下载免费PDF全文
79.
Majid Salehi Mahdi Naseri-Nosar Somayeh Ebrahimi-Barough Mohammdreza Nourani Ahmad Vaez Saeed Farzamfar Jafar Ai 《The journal of physiological sciences : JPS》2018,68(5):579-587
The current study aimed to enhance the efficacy of peripheral nerve regeneration using a hydroxyapatite nanoparticle-containing collagen type I hydrogel. A solution of type I collagen, extracted from the rat tails, was incorporated with hydroxyapatite nanoparticles (with the average diameter of ~212 nm) and crosslinked with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) to prepare the hydrogel. The Schwann cell cultivation on the prepared hydrogel demonstrated a significantly higher cell proliferation than the tissue culture plate, as positive control, after 48 h (n = 3, P < 0.005) and 72 h (n = 3, P < 0.01). For in vivo evaluation, the prepared hydrogel was administrated on the sciatic nerve crush injury in Wistar rats. Four groups were studied: negative control (with injury but without interventions), positive control (without injury), collagen hydrogel and hydroxyapatite nanoparticle-containing collagen hydrogel. After 12 weeks, the administration of hydroxyapatite nanoparticle-containing collagen significantly (n = 4, P < 0.005) enhanced the functional behavior of the rats compared with the collagen hydrogel and negative control groups as evidenced by the sciatic functional index, hot plate latency and compound muscle action potential amplitude measurements. The overall results demonstrated the applicability of the produced hydrogel for the regeneration of peripheral nerve injuries. 相似文献
80.
Mahdi H Swensen RE Munkarah AR Chiang S Luhrs K Lockhart D Kumar S 《Gynecologic oncology》2011,122(2):344-349