胡桃楸对电离辐射损伤小鼠免疫功能的影响

目的:探讨胡桃楸乙醇提取物（AEBJ）对电离辐射所致小鼠免疫功能损伤的影响。方法：60只小鼠随机分为假照射组、照射对照组、AEBJ低剂量（300 mg•kg^-1）照射给药组、AEBJ高剂量（600 mg•kg^-1）照射给药组、AEBJ低剂量单纯给药组和AEBJ高剂量单纯给药组6个实验组,检测小鼠外周血白细胞数、淋巴细胞百分数、淋巴细胞绝对值、脏器指数和Con A刺激小鼠脾淋巴细胞增殖能力。结果：照射对照组小鼠外周血白细胞数、淋巴细胞绝对值、淋巴细胞百分数、脏器指数和Con A诱导的脾淋巴细胞增殖反应能力均低于假照射组（P< 0.05）;AEBJ高、低剂量照射给药组小鼠外周血白细胞数、淋巴细胞绝对值、淋巴细胞百分数、脏器指数和Con A诱导的脾淋巴细胞增殖反应能力均高于照射对照组（P< 0.05）;AEBJ高、低剂量单纯给药组的淋巴细胞百分数和Con A诱导的脾淋巴细胞增殖反应能力均高于假照射组（P< 0.05）。结论：AEBJ对电离辐射所致的小鼠免疫功能损伤有保护和修复作用。     

洪涝灾害公共卫生风险评估指标体系的构建及应用

目的: 构建洪涝灾害公共卫生风险评估指标体系,为灾害期间公共卫生风险等级评估提供定量化判断依据。方法: 采用德尔菲法和专家会商法构建洪涝灾害公共卫生风险评估相关指标及其评分标准,运用层次分析法获得指标的权重,并进一步应用于安徽省2016年洪涝灾害公共卫生风险评估中。结果: 构建并确定了五大类17个洪涝灾害公共卫生风险评估指标、评分标准及其权重。根据构建的指标体系,2016年安徽省洪涝灾害公共卫生风险总分为0.26分,风险判断结果为"灾害期间卫生应急措施有效,公共卫生风险有效控制"。结论: 本研究构建的洪涝灾害公共卫生风险评估指标体系可为灾害现场开展定量评估提供技术支持,同时也可为其他类型灾害现场评估提供参考。     

阿立哌唑与利培酮治疗老年期精神分裂症对照研究

目的：探讨阿立哌唑治疗老年期精神分裂症的疗效和安全性。方法：采用随机方法将98例老年期精神分裂症患者分为两组，阿立哌唑组49例，剂量10-30mg／日，利培酮组49例，剂量2-4mg／日，疗程12周。疗效评定采用阳性和阴性症状量表（PANSS），不良反应评定采用（TESS）量表。结果：阿立哌唑组与利培酮组相比，总体疗效相当。阿立哌唑组的药物不良反应较少。结论：阿立哌唑对老年期精神分裂症有良好的疗效，且安全性较好。     

Congenital Rosai–Dorfman disease presenting with anemia,thrombocytopenia, and hepatomegaly

Rosai–Dorfman disease (RDD) is a rare entity of non‐Langerhans cell histiocytoses (non‐LCH) which usually presents with bilateral painless cervical lymphadenopathy. We describe a neonate with RDD who presented with anemia, thrombocytopenia and hepatomegaly. He recovered spontaneously with conservative management. This represents an atypical presentation of RDD. Conservative management with close monitoring can be adopted for some with systemic involvement. Pediatr Blood Cancer 2009;52:415–417. © 2008 Wiley‐Liss, Inc.     

Deep Vein Thrombosis and Pulmonary Embolism in Cirrhosis Patients

Background and Aims It is a commonly held notion that patients with cirrhosis do not suffer from deep vein thrombosis (DVT) or pulmonary embolism (PE) because they are naturally anticoagulated. However, to date, no studies have been carried out that objectively address this issue. We conducted a study to examine the relationship between cirrhosis and DVT/PE events. Methods A case–control study of patients seen at a tertiary care hospital was performed. Cases were hospitalized patients with biopsy and/or imaging plus clinical evidence of cirrhosis. Well-matched patients with no known evidence of cirrhosis served as controls. The DVT/PE events were identified by the international classification of disease-9 (ICD-9) codes and confirmed with radiographic/nuclear imaging. The Charlson Index was calculated to determine the comorbidity. The incidence of DVT/PE in cirrhotic patients was also compared to patients with chronic kidney disease (CKD), congestive heart failure (CHF), and solid organ cancers. Results This study consisted of 963 cirrhotics and 12,405 controls. Both the incidence of DVT/PE (1.8 vs. 0.9%, P = 0.007) and Charlson Index scores (3.2 ± 1.8 vs. 0.9 ± 1.5, P < 0.001) were higher in cirrhotics than in the controls. However, in the multivariate analysis, the presence of cirrhosis was not associated with DVT/PE [odds ratio (OR) 0.87, P = 0.06]. Partial thromboplastin time (PTT; OR 0.88, P = 0.04) and serum albumin (OR 0.47, P = 0.03) were the independent predictors of DVT/PE. The incidence of DVT/PE in cirrhotics (1.8%) was lower than that in patients with other medical illnesses: 7.1% in CKD, 7.8% in CHF, and 6.1% in cancers. Conclusion Patients with cirrhosis do not have a lower risk of DVT/PE than non-cirrhotic controls without other significant co-morbidities, such as CHF, CKD, and solid organ cancers. Partial thromboplastin time and serum albumin were found to be independently predictive of DVT/PE in cirrhotic patients.