排序方式: 共有17条查询结果,搜索用时 15 毫秒
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NAQVI N.; THOMPSON D. S.; JUUL S. M.; JENKINS B. S.; WEBB-PEPLOE M. M.; COLTART D. J. 《European heart journal》1980,1(4):255-261
In animal experiments oxfenicine (L-hydroxyphenylglycine) (LHPG)has been shown to increase myocardial carbohydrate utilizationand decrease fat consumption. Seven patients, six of whom provedto have coronary artery disease, were studied during diagnosticcardiac catheterization. Myocardial substrate extraction, coronarysinus flow, cardiac output and left ventricular pressure weremeasured at basal heart rale and three pacing rates before andafter 800 mg oxfenicine (LHPG). A small decrease in systolicpressure at low heart rates and reduction of end-diastolic pressureat the highest pacing rate were the only haemodynamic changesobserved after the drug. Coronary sinus flow and myocardialoxygen uptake did not change, although there was a small fallin arterio-venous oxygen difference at basal heart rate. Afterthe drug lactale extraction ratio increased in all patientsat each heart rate. Pyruvate extraction ratio increased afteroxfenicine (LHPG) significantly at basal heart rate and thelowest pacing rate. Arterial free fatty acid concentration roseand extraction ratio fell. It is concluded that oxfenicine (LHPG)has a potent effect upon lactate metabolism and is without majorhaemodynamic effects. 相似文献
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Summary. Frequent infusion of factor concentrates may be challenging in young boys with haemophilia, especially if their disease is complicated by inhibitors. A central venous access device (CVAD) is often placed in young patients in need of repeated infusions for prophylaxis or immune tolerance induction. Although user friendly and capable of providing reliable venous access, these devices are associated with a high complication rate over time. In the haemophilia population, major complications include CVAD-associated infections and deep venous thrombosis, which is most often silent. Established risk factors for catheter-related infection include age less than 6 years at the time of CVAD placement and use of an external CVAD when compared with a totally implantable device such as a port. Avoidance of CVAD-related infections is facilitated by strict adherence to aseptic technique. The risk of deep venous thrombosis appears related to the duration for which the catheter is in place, with the risk increasing beyond 4 years. The promotion of a strict clinic policy in which CVADs are left in place for as short a time as possible should decrease the risk of complications. In rare cases where a totally implantable CVAD cannot be placed for technical reasons, an arteriovenous fistula may provide reliable venous access. In all cases, however, venous access via peripheral veins is preferred over CVADs. 相似文献
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TASNEEM Z. NAQVI M.D. M.R.C.P. ROBERT J. SIEGEL M.D. F.A.C.C. 《Echocardiography (Mount Kisco, N.Y.)》1999,16(7):677-688
Noninvasive assessment of aortic valve area by echocardiography has become the standard of practice over the past few years. The advent of transesophageal echocardiography (TEE) has provided a new method for the assessment of aortic valve area (AVA) using planimetry by two-dimensional imaging. Clear visualization of the anatomy of the valve, as well as accuracy of AVA assessment, makes TEE an invaluable tool for the evaluation of aortic valve stenosis. TEE is especially helpful in clinical settings when there is a discrepancy between the AVA obtained by transthoracic echocardiography and cardiac catheterization. TEE is particularly helpful in the assessment of the aortic valve during intraoperative echocardiography. This review discusses the techniques, imaging planes, and details for assessing AVA by TEE. The role of TEE in AVA assessment is described, with specific clinical case examples cited. 相似文献
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The criteria for an oxygen fail-safe device are designed toprevent a hypoxic gas mixture being administered to the patientshould the oxygen supply fail, be disconnected, or be turnedoff. A fail-safe device which fulfils these criteria is described. 相似文献
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M. C. LINDBERG R. H. NAQVI S. A. MATLIN R. H. ZHOU G. BIALY† R. P. BLYE† 《International journal of andrology》1987,10(4):619-623
The enantiomers of gossypol have been tested as male oral anti-fertility agents in hamsters. As determined by fertility tests the (-) isomer was fully active at half the effective dose of the racemate, whereas the (+) isomer exerted no anti-fertility effect. 相似文献