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排序方式: 共有2246条查询结果,搜索用时 15 毫秒
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Jaime C. Sapag Brena F. Sena Inés V. Bustamante Sireesha J. Bobbili Paola R. Velasco Franco Mascayano 《Global public health》2018,13(10):1468-1480
Stigma towards mental illness and addictive disorders is a global problem and one of the main obstacles in tackling this issue remains the effective integration of mental health services into primary health care (PHC). In Latin America, information has significantly increased on the existence of stigma; however, little is known about effective interventions to prevent stigma and promote recovery-oriented practices in PHC. The aim of this study is to understand the existing evidence regarding mental health stigma in PHC with a special focus on the Latin American region. A scoping review of the literature related to mental health stigma in PHC was conducted. Two hundred and seventeen articles were evaluated; 74 met inclusion criteria and 14 additional articles were selected from references of search results. Results were subdivided into five different perspectives: users, family members and significant others, health professionals, contextual factors, and potential effective interventions. Only nine studies were based in Latin America, and only one described an intervention to reduce stigma in mental health services, not specifically in PHC. We found an urgent need to develop interventions to understand and reduce stigma in PHC settings, especially in Latin America. 相似文献
65.
Uzcudun AE Batlle JF Velasco JC Sánchez Santos ME Carpeño Jde C Grande AG Juberías AM Piñeiro EH Olivar LM García AG 《Diseases of the colon and rectum》2002,45(10):1349-1358
PURPOSE: The aim of this study was to evaluate the efficacy of preoperative radiation therapy for resectable rectal adenocarcinoma (T3-T4) when delivered in combination with chemotherapy (oral tegafur-uracil modulated with leucovorin).
METHODS: Thirty-eight patients (23 males; mean age, 62 years.) with histologically proven rectal adenocarcinoma with primary tumor clinical classification T3-T4 (resectable) and N0 or N1-N2, according to TNM staging system, took part in the present clinical trial. After tumor and metastasis resectability confirmation, radiation therapy was administered by delivering a dose of 45 Gy in 25 fractions for 5 weeks. Chemotherapy treatment was initiated on the same day as radiotherapy and consisted of intravenous infusion of 6S-steroisomer of leucovorin 250 mg/m2/day in 2 hours on Day 1, followed by oral 350 or 300 mg/m2/day of tegafur (a 5-fluorouracil prodrug) plus uracil on Days 1 to 14 divided into 2 daily doses, and oral 6S-steroisomer of leucovorin 7.5 mg/12 hours on Days 2 to 14, with a total of 102 courses of neoadjuvant chemotherapy (i.e., mean of 2.7 courses per patient). Six additional courses of tegafur-uracil were given postoperatively to all 38 patients but 1 who refused.
RESULTS: As a result of preoperative chemoradiation treatment, 4 (10.5 percent) complete responses, 20 (52.6 percent) partial responses, and 14 (36.8 percent) patients with disease stabilization were observed. No patients had preoperative disease progression. Histologically proven downstaging was observed in 23 (60 percent) patients. On initial evaluation, only 39 percent of patients were considered as being good candidates for sphincter-preserving surgery; however, on preoperative chemoradiation completion this figure increased up to 60 percent. For the 23 patients eventually undergoing sphincter-preserving surgery, postoperative sphincter function assessment showed excellent function in 15 (65 percent) patients, good in 5 (22 percent), fair in 2 (9 percent), and poor in 1(4 percent). With a median follow-up of 37 (range, 10–62) months, local failure was found in 3 (8 percent) patients and distant failure in 2 (5 percent). Three-year actuarial disease-free survival and 3-year overall survival rates were 83 and 90 percent, respectively. Local control rate was 92 percent. Toxicity and postoperative complication rates were reasonable.
CONCLUSIONS: Our neoadjuvant radiation therapy protocol is efficient for the preoperative treatment of resectable rectal adenocarcinoma when combined with chemotherapy (oral tegafur-uracil modulated with leucovorin). However, this protocol needs to be tested in a phase-III clinical trial with a larger sample size. 相似文献
66.
The aim of our study was to perform a review of the literature to assess the results of prevention and treatment of stoma complications. 相似文献
67.
Michelle N. Valadão Érica R. Coimbra Michele C. Landemberger Tonicarlo R. Velasco Vera C. Terra Lauro Wichert-Ana Veriano Alexandre Jr. David Araújo Jr. Ricardo Guarnieri Vilma R. Martins Antônio Carlos Santos Américo C. Sakamoto Roger Walz 《Neurological sciences》2014,35(2):239-244
The cellular prion protein, encoded by Prnp gene, is involved in neuroprotection, neuroplasticity and neurodevelopment. The variant allele Valine at codon 129 of the Prnp was associated with decreased brain volume in healthy volunteers and schizophrenic patients. We investigate the association between the cerebellum volume and the presence of variant allele Valine at codon 129 of the Prnp gene in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). The Prnp coding sequence was determined in 41 refractory MTLE-HS patients. The cerebellum volume corrected by the intracranial volume of patients with the normal Prnp genotypes was compared with that of patients presenting the variant alleles at codon 129. Twenty patients showed the Met129Met genotype, 16 showed Met129Val, and 5 had Val129Val. There were no association among clinical, demographic, electrophysiological, antiepileptic drugs used, and the presence of the Prnp variant alleles. The presence of Prnp variant allele at codon 129 was not associated with the analyzed cerebellum volume. Prnp variant alleles at codon 129 are not associated with cerebellum volume in patients with refractory MTLE-HS. 相似文献
68.
Castillo-Bautista Cristina M. Torres-Tapia Luis W. Rangel-Méndez Jorge A. Peraza-Sánchez Sergio R. Cortés Daniel Velasco Iván Moo-Puc Rosa E. 《Journal of natural medicines》2019,73(3):672-678
Journal of Natural Medicines - Neurological disorders are a public health problem worldwide for which there is currently no direct treatment of the cause of the disorder. The goal of this study was... 相似文献
69.
Menezes-Silva Rafael Velasco S. R. M. Bastos R. S. Molina G. Honório H. M. Frencken J. E. Navarro M. F. L. 《Clinical oral investigations》2019,23(9):3623-3635
Clinical Oral Investigations - This study evaluated the effectiveness of class II restorations, in permanent teeth, through the ART technique in comparison to composite resin. Participants (154),... 相似文献
70.
David Velasco Manuel Sánchez de Miguel Maitane Egurza Enrique Arranz Aritz Aranbarri Eduardo Fano Jesús Ibarluzea 《Gaceta sanitaria / S.E.S.P.A.S》2014