收费全文 | 5167篇 |
免费 | 211篇 |
国内免费 | 38篇 |
耳鼻咽喉 | 16篇 |
儿科学 | 79篇 |
妇产科学 | 49篇 |
基础医学 | 693篇 |
口腔科学 | 149篇 |
临床医学 | 277篇 |
内科学 | 1440篇 |
皮肤病学 | 79篇 |
神经病学 | 366篇 |
特种医学 | 270篇 |
外科学 | 884篇 |
综合类 | 22篇 |
预防医学 | 157篇 |
眼科学 | 127篇 |
药学 | 325篇 |
中国医学 | 3篇 |
肿瘤学 | 480篇 |
2023年 | 28篇 |
2022年 | 53篇 |
2021年 | 85篇 |
2020年 | 50篇 |
2019年 | 70篇 |
2018年 | 109篇 |
2017年 | 82篇 |
2016年 | 100篇 |
2015年 | 105篇 |
2014年 | 116篇 |
2013年 | 177篇 |
2012年 | 290篇 |
2011年 | 321篇 |
2010年 | 175篇 |
2009年 | 156篇 |
2008年 | 290篇 |
2007年 | 335篇 |
2006年 | 305篇 |
2005年 | 322篇 |
2004年 | 305篇 |
2003年 | 322篇 |
2002年 | 331篇 |
2001年 | 99篇 |
2000年 | 112篇 |
1999年 | 96篇 |
1998年 | 89篇 |
1997年 | 67篇 |
1996年 | 53篇 |
1995年 | 29篇 |
1994年 | 47篇 |
1993年 | 45篇 |
1992年 | 68篇 |
1991年 | 69篇 |
1990年 | 46篇 |
1989年 | 73篇 |
1988年 | 53篇 |
1987年 | 60篇 |
1986年 | 52篇 |
1985年 | 44篇 |
1984年 | 25篇 |
1983年 | 20篇 |
1982年 | 17篇 |
1981年 | 9篇 |
1980年 | 10篇 |
1979年 | 10篇 |
1978年 | 14篇 |
1975年 | 7篇 |
1971年 | 11篇 |
1970年 | 7篇 |
1966年 | 8篇 |
Design: Prospective pharmacokinetic study of sevofurane administration in human subjects.
Setting: Inpatient surgery clinic at a university medical center.
Patients: Thirty-two Japanese patients, free of systemic diseases, undergoing minor elective surgery with endotracheal general anesthesia.
Interventions: The patients were assigned randomly to one of four groups: halothane, enflurane, isofurane, or sevofurane. One of the four volatile anesthetics being investigated [equivalent to 1.1 minimum alveolar concentration (MAC): halothane, 0.85%; enfurane, 1.85%; isofurane, 1.27%; and sevofurane, 1.88%; in inspired concentrations throughout the first hour of anesthesia] was administered for 60 minutes.
Measurements and Main Results: In all patients, serum and urinary fluoride concentrations were measured. The concentrations of all gases were measured separately with a mass spectrometer. The cumulative uptake of each anesthetic agent during a certain period was calculated as an integration of the uptake rate per minute. The results for one-hour inhalation of sevofurane (1.1 MAC) showed an uptake (corrected for body surface area and MAC) of 490 ml/m2/MAC and estimated degradation rate of 3.3%. For purposes of comparison, similar studies of halothane (uptake, 653 ml/m2/MAC; degradation rate 15.7%), enfurane (1150 ml/m2/MAC; 1.3%), and isofurane (439 ml/m2/MAC; 0.6%) were also conducted. Sevofurane had a peak serum inorganic fluoride concentration of 19.3 μmol/L, and no abnormality in hepatic or renal functions was observed in any of the subjects during the two weeks postoperatively.
Conclusions: Accurate determinations of uptake and degradation rate for sevoflurane and three other volatile anesthetics in Japanese patients were obtained. These findings have established that, despite its relatively large MAC *1.71%), sevoflurane has a small uptake due to its low solubility. However, the degradation rade was shown to be as high as 3.3%, resulting in a higher serum fluoride concentration than seen after administration of isoflurane, halothane, and (possibly) enflurane. 相似文献