全文获取类型
收费全文 | 1182篇 |
免费 | 48篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 50篇 |
妇产科学 | 6篇 |
基础医学 | 118篇 |
口腔科学 | 12篇 |
临床医学 | 98篇 |
内科学 | 292篇 |
皮肤病学 | 3篇 |
神经病学 | 45篇 |
特种医学 | 330篇 |
外科学 | 100篇 |
综合类 | 17篇 |
预防医学 | 66篇 |
眼科学 | 10篇 |
药学 | 61篇 |
中国医学 | 1篇 |
肿瘤学 | 51篇 |
出版年
2021年 | 12篇 |
2020年 | 6篇 |
2019年 | 5篇 |
2018年 | 14篇 |
2017年 | 6篇 |
2016年 | 8篇 |
2015年 | 16篇 |
2014年 | 22篇 |
2013年 | 29篇 |
2012年 | 26篇 |
2011年 | 22篇 |
2010年 | 26篇 |
2009年 | 30篇 |
2008年 | 25篇 |
2007年 | 48篇 |
2006年 | 32篇 |
2005年 | 27篇 |
2004年 | 28篇 |
2003年 | 16篇 |
2002年 | 30篇 |
2001年 | 22篇 |
2000年 | 14篇 |
1999年 | 24篇 |
1998年 | 57篇 |
1997年 | 44篇 |
1996年 | 62篇 |
1995年 | 47篇 |
1994年 | 38篇 |
1993年 | 39篇 |
1992年 | 15篇 |
1991年 | 15篇 |
1990年 | 15篇 |
1989年 | 39篇 |
1988年 | 43篇 |
1987年 | 34篇 |
1986年 | 27篇 |
1985年 | 43篇 |
1984年 | 24篇 |
1983年 | 25篇 |
1982年 | 27篇 |
1981年 | 25篇 |
1980年 | 13篇 |
1979年 | 6篇 |
1978年 | 8篇 |
1977年 | 30篇 |
1976年 | 25篇 |
1975年 | 20篇 |
1973年 | 12篇 |
1972年 | 10篇 |
1969年 | 7篇 |
排序方式: 共有1263条查询结果,搜索用时 0 毫秒
41.
42.
43.
Andrew Luu Fahd Syed Gowri Raman Anshul Bhalla Eavan Muldoon Susan Hadley Eric Smith Madhumathi Rao 《The Journal of arthroplasty》2013
Periprosthetic infections of hip and knee joints are now treated by two-stage revision arthroplasty with an infection control rate of 91%. The present systematic review studied the reported incidence of acute kidney injury (AKI) and infection recurrence from January 1989 to June 2012 to assess the risk–benefit ratio of antibiotic spacer use. Ten observational studies (n = 544 patients) with clinical outcomes showed an average incidence of AKI of 4.8%. The average reported persistence or recurrence rate of infection was 11% during a follow-up period that ranged from 13 to 108 months. The risk–benefit ratio presently favors treatment although there appears to be higher complication rates and incidence of AKI than previously reported. Marked heterogeneity in practice and lack of detail in reporting precluded more robust quantitative synthesis. Clinicians need to be aware of the potential risk of AKI, particularly in high-risk patients; practice patterns for the use of antibiotic spacers need to be standardized. 相似文献
44.
Ferran Marsa-Sambola Janine Muldoon Joanne Williams Alistair Lawrence Melanie Connor Candace Currie 《Child indicators research》2016,9(1):111-131
This study describes the development of the SAPS and investigates its reliability and validity within the context of the Health Behaviour in School-Aged Children Survey (HBSC) which gathered data on representative samples of school pupils aged 11, 13 and 15 in Scotland and England. In the development of SAPS, following a comprehensive review of the literature, two small-scale empirical studies were carried out (one qualitative and one quantitative). Regarding the validation process, the reliability and validity of the SAPS was assessed in a sub-sample (n?=?7159) of pupils who completed the HBSC survey and were identified as owning pets. Factor analysis resulted in a one-factor solution (explaining 67.78 % of the variance); Cronbach’s alpha for the scale was 0.894. The item-total correlation ranged from 0.368 to 0.784. A linear model showed that attachment to pets was associated with age (being 11 or 13 years old), being a girl, white ethnicity, and considering a pet as one’s own. SAPS scores were also positively associated with quality of life. The total variance in SAPS explained by these variables was 15.7 %. Effect sizes of associations were medium (age, considering a pet as one’s own) and small (ethnicity, age, gender, quality of life). The study concludes that SAPS is a coherent and psychometrically sound measure. It is associated with a range of demographic variables and quality of life, which confirms its utility as a new succinct measure of children’s and young people’s attachment to pets for use in health and social science research. 相似文献
45.
O'Malley CJ; Rasko JE; Basser RL; McGrath KM; Cebon J; Grigg AP; Hopkins W; Cohen B; O'Byrne J; Green MD; Fox RM; Berndt MC; Begley CG 《Blood》1996,88(9):3288-3298
This report describes the effect of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet production and platelet function in humans. Subjects with advanced solid tumors received PEG-rHuMGDF daily for up to 10 days. There was no increase in circulating platelet count at doses of 0.03 or 0.1 microgram/kg/d by day 12 of study. At doses of 0.3 and 1.0 microgram/kg/d there was a threefold median increase (maximum 10-fold) in platelet count by day 16. The platelets produced in vivo in response to PEG-rHuMGDF showed unchanged aggregation and adenosine triphosphate (ATP)-release responses in in vitro assays. Tests included aggregation and release of ATP in response to adenosine diphosphate (ADP) (10, 5, 2.5, and 1.25 mumol/L), collagen (2 micrograms/mL), thrombin-receptor agonist peptide (TRAP, 10 mumol/L) and ristocetin (1.5 mg/mL). Administration of aspirin to an individual with platelet count of 1,771 x 10(3)/L resulted in the typical aspirin-induced ablation of the normal aggregation and ATP-release response to stimulation with arachidonic acid (0.5 mg/mL), collagen, and ADP (2.5 and 1.25 mumol/L). There was no change in the expression of the platelet-surface activation marker CD62P (P-selectin) nor induction of the fibrinogen binding site on glycoprotein IIb/IIIa as reported by the monoclonal antibody, D3GP3. An elevation of reticulated platelets was evident after 3 days of treatment with PEG-rHuMGDF and preceded the increase in circulating platelet count by 5 to 8 days; this reflected the production of new platelets in response to PEG-rHuMGDF. At later time points, the mean platelet volume (MPV) decreased in a manner inversely proportional to the platelet count. Levels of plasma glycocalicin, a measure of platelet turnover, rose 3 days after the initial increase in the peripheral platelet count. The level of plasma glycocalicin was proportional to the total platelet mass, suggesting that platelets generated in response to PEG-rHuMGDF were not more actively destroyed. Thus, the administration of PEG-rHuMGDF, to humans, increased the circulating platelet count and resulted in fully functional platelets, which showed no detectable increase in reactivity nor alteration in activation status. 相似文献
46.
New Zealand Black (NZB) autoimmune mice exhibit progressive, age- dependent reduction in bone marrow pre-B cells. To ascertain the capacity of NZB bone marrow B220- cells to generate pre-B cells in a supportive environment, B-lineage (B220+) cell-depleted and T-cell- depleted bone marrow cells from NZB mice at 1 to 3, 6, and 10 to 11 months of age were adoptively transferred into irradiated (200R) C.B17 severe combined immunodeficient (SCID) mice. Bone marrow pre-B cells (sIgM- CD43[S7]- B220+) were assessed 3 and 10 weeks posttransfer. Pre- B cells and B cells were reconstituted in SCID recipients of older NZB progenitor cells by 10 weeks posttransplant, in contrast to the very low numbers of pre-B cells present in the donor bone marrow. However, B220- bone marrow progenitor cells from greater than 10-month-old NZB donors were deficient in the reconstitution of both pre-B and B cells in SCID recipients at 3 weeks post-transfer. This reflected a slower kinetics of repopulation, because older NZB-->SCID recipients had numbers of both pre-B and B cells similar to recipients of young NZB progenitor cells by 10 weeks posttransplant. Adoptive transfer of equal mixtures of BALB/c and older NZB bone marrow B220- progenitor cells into irradiated C.B17 SCID recipients failed to demonstrate active suppression. These results suggest that, with age, NZB bone marrow has reduced numbers and/or function of early B220- B-lineage progenitors. Consistent with this hypothesis, B220- bone marrow cells from older NZB mice were deficient in progenitors capable of yielding interleukin-7 (IL-7) responsive pre-B cells in vitro on stimulation with the pre-B- cell potentiating factor, insulin-like growth factor 1 (IGF-1). 相似文献
47.
Value of CT–PET after neoadjuvant chemoradiation in the prediction of histological tumour regression,nodal status and survival in oesophageal adenocarcinoma 下载免费PDF全文
48.
49.
鸟氨酸脱羧酶的生理病理特点及其药物研究概况 总被引:2,自引:0,他引:2
鸟氨酸脱羧酶(ornithinedecarboxylase,ODC)是多胺代谢中的关键酶,广泛存在于人体和动物各组织细胞内,其中对肠细胞的增生、移行和分化起重要作用.机体调节因素比较复杂.在黏膜损伤性疾病及某些癌前病变等细胞大量增生的病理情况下ODC的表达发生改变,可以作为这些疾病分期、预后及药物作用靶点或疗效的指标.寻找对ODC有作用的药物对于治疗其相关疾病是非常有意义的. 相似文献
50.