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121.
Jeyamani Ramachandran Ashrafali Mohamed Ismail Gaurav Chawla Gnanadurai John Fletcher Ashish Goel C. E. Eapen Priya Abraham 《Indian journal of gastroenterology》2014,33(2):131-135
Background and Aims
There is paucity of Indian data regarding serum HBsAg levels (qHBsAg) in treatment-naïve chronic hepatitis B (CHB). This study was done to determine correlation of qHBsAg with hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels and its ability to independently categorize subgroups of CHB.Methods
We studied 131 treatment-naive CHB patients and initially classified them based on HBeAg status. The HBeAg-positive group was further classified into immune tolerance (IT) and immune clearance (IC) phases based on serum alanine aminotransferase. HBeAg-negative patients were classified into low replicators (LR) and HBeAg-negative chronic hepatitis (ENH) based on DNA levels. HBsAg quantification was performed using the Architect chemiluminescence system.Results
HBeAg-positive patients had higher DNA (7.89 vs. 2.69 log10?IU/mL) and higher qHBsAg (4.60 vs. 3.85 log10?IU/mL) compared to the HBeAg-negative group. Good correlation between qHBsAg and DNA was seen in HBeAg-positive (ρ?=?0.6, p?<?0.001) but not in HBeAg-negative CHB (ρ?=?0.2). A qHBsAg level greater than 4.39 log10?IU/mL predicted HBeAg-positive state with 81 % sensitivity and 85 % specificity. However, among HBeAg-negative CHB, qHBsAg failed to discriminate between LR and ENH.Conclusions
A single point estimation of qHBsAg in treatment-naïve patients could predict replicative HBeAg-positive CHB, but was not helpful in defining replicative status in the HBeAg-negative CHB. 相似文献122.
Singh Abhishek Priyambada Prajnashree Jabin Gul Singh Sujeet Kumar Joshi Bheem Dutt Venkatraman Chinnadurai Chandra Kailash Sharma Lalit Kumar Thakur Mukesh 《International journal of legal medicine》2020,134(5):1613-1618
International Journal of Legal Medicine - Demand for pangolin scales in East Asia has increased dramatically in the past two decades, raising concern to the pangolin survival and bringing them to... 相似文献
123.
Dhavalkumar Patel Prashant S. Kharkar Neha S. Gandhi Ekjot Kaur Shilpee Dutt Mukesh Nandave 《Drug development research》2019,80(6):758-777
System xc− (Sxc−), a cystine-glutamate antiporter, is established as an interesting target for the treatment of several pathologies including epileptic seizures, glioma, neurodegenerative diseases, and multiple sclerosis. Erastin, sorafenib, and sulfasalazine (SSZ) are a few of the established inhibitors of Sxc−. However, its pharmacological inhibition with novel and potent agents is still very much required due to potential issues, for example, potency, bioavailability, and blood–brain barrier (BBB) permeability, with the current lead molecules such as SSZ. Therefore, in this study, we report the synthesis and structure–activity relationships (SAR) of SSZ derivatives along with molecular docking and dynamics simulations using the developed homology model of xCT chain of Sxc− antiporter. The generated homology model attempted to address the limitations of previously reported comparative protein models, thereby increasing the confidence in the computational modeling studies. The main objective of the present study was to derive a suitable lead structure from SSZ eliminating its potential issues for the treatment of glioblastoma multiforme (GBM), a deadly and malignant grade IV astrocytoma. The designed compounds with favorable Sxc− inhibitory activity following in vitro Sxc− inhibition studies, showed moderately potent cytotoxicity in patient-derived human glioblastoma cells, thereby generating potential interest in these compounds. The xCT-ligand model can be further optimized in search of potent lead molecules for novel drug discovery and development studies. 相似文献
124.
125.
126.
Aadithya B. Urs Jeyaseelan Augustine Himanshi Chawla 《Journal of maxillofacial and oral surgery》2014,13(4):458-463
Aim
The aim of the present study was to analyze clinical, radiological and histopathological features of aneurysmal bone cysts (ABCs) of jaws.Materials and Methods
Archival data from 2009 to 2012 present in the Oral Pathology Department was retrieved and clinicopathological features of all the cases which had been previously diagnosed as ABC were analyzed in detail.Results
Seven cases ranging in age from 10 to 50 years were included, in which maximum (5/7) cases were below 20 years. Ratio of presentation of lesion in male to female and in maxilla to mandible was 3:6 and 1:6 respectively. Swelling and pain were the most common presenting features. Variable presentation of the lesion was observed radiographically; although multilocular, well defined, bone expansion and perforation were the most common observations. Histopathological analysis revealed association of one case with ossifying fibroma and two cases with trabecular variety of juvenile ossifying fibroma. Predominance of solid variety was noted and other features like stroma, giant cells, nature of blood vessels, bone destruction and perforation and presence of any osteoid or calcified material was also accounted for. The current study showed association of two cases with trabecular variety of juvenile ossifying fibroma, which is a rare finding.Conclusion
ABCs of jaws, thus have varying patterns of presentation which are diagnostically challenging. A thorough examination of the incisional/excisional tissue is thus required to confirm the association with any other lesion which will affect the treatment plan for the patient. 相似文献127.
Although debated, most preeminent expert panels recommend routine screening for gestational diabetes mellitus (GDM). Among
the many tests that have been used and evaluated for the screening of GDM, the fasting plasma glucose (FPG) remains very appealing.
It is easy to administer, well tolerated, inexpensive, reproducible and patient friendly. However attractive, the FPG has
given varied results in different populations and its use as a screening test for GDM remains uncertain. This review will
objectively assess the available studies to find the real value of FPG as a screening test for GDM. 相似文献
128.
Feng Zhu Veasna Duong Xiao Fang Lim Vibol Hul Tanu Chawla Lucy Keatts Tracey Goldstein Alexandre Hassanin Vuong Tan Tu Philippe Buchy October M. Sessions Lin-Fa Wang Philippe Dussart Danielle E. Anderson 《Viruses》2022,14(2)
Bats have been recognized as an exceptional viral reservoir, especially for coronaviruses. At least three bat zoonotic coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) have been shown to cause severe diseases in humans and it is expected more will emerge. One of the major features of CoVs is that they are all highly prone to recombination. An extreme example is the insertion of the P10 gene from reoviruses in the bat CoV GCCDC1, first discovered in Rousettus leschenaultii bats in China. Here, we report the detection of GCCDC1 in four different bat species (Eonycteris spelaea, Cynopterus sphinx, Rhinolophus shameli and Rousettus sp.) in Cambodia. This finding demonstrates a much broader geographic and bat species range for this virus and indicates common cross-species transmission. Interestingly, one of the bat samples showed a co-infection with an Alpha CoV most closely related to RsYN14, a virus recently discovered in the same genus (Rhinolophus) of bat in Yunnan, China, 2020. Taken together, our latest findings highlight the need to conduct active surveillance in bats to assess the risk of emerging CoVs, especially in Southeast Asia. 相似文献
129.
The Asia–Pacific Working Party on Non‐alcoholic Fatty Liver Disease guidelines 2017—Part 2: Management and special groups 下载免费PDF全文
Shiv Chitturi Vincent Wai‐Sun Wong Wah‐Kheong Chan Grace Lai‐Hung Wong Simon Kin‐Hung Wong Jose Sollano Yen‐Hsuan Ni Chun‐Jen Liu Yu‐Cheng Lin Laurentius Adrianto Lesmana Seung Up Kim Etsuko Hashimoto Masahide Hamaguchi Khean‐Lee Goh Jiangao Fan Ajay Duseja Yock Young Dan Yogesh Chawla Geoff Farrell Henry Lik‐Yuen Chan 《Journal of gastroenterology and hepatology》2018,33(1):86-98