全文获取类型
收费全文 | 1654篇 |
免费 | 174篇 |
国内免费 | 54篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 108篇 |
妇产科学 | 48篇 |
基础医学 | 163篇 |
口腔科学 | 62篇 |
临床医学 | 164篇 |
内科学 | 422篇 |
皮肤病学 | 33篇 |
神经病学 | 55篇 |
特种医学 | 200篇 |
外科学 | 156篇 |
综合类 | 109篇 |
预防医学 | 108篇 |
眼科学 | 16篇 |
药学 | 116篇 |
中国医学 | 9篇 |
肿瘤学 | 100篇 |
出版年
2024年 | 4篇 |
2023年 | 22篇 |
2022年 | 23篇 |
2021年 | 58篇 |
2020年 | 53篇 |
2019年 | 36篇 |
2018年 | 47篇 |
2017年 | 66篇 |
2016年 | 56篇 |
2015年 | 47篇 |
2014年 | 90篇 |
2013年 | 103篇 |
2012年 | 79篇 |
2011年 | 77篇 |
2010年 | 91篇 |
2009年 | 102篇 |
2008年 | 58篇 |
2007年 | 90篇 |
2006年 | 51篇 |
2005年 | 31篇 |
2004年 | 32篇 |
2003年 | 23篇 |
2002年 | 17篇 |
2001年 | 36篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 81篇 |
1997年 | 64篇 |
1996年 | 59篇 |
1995年 | 51篇 |
1994年 | 45篇 |
1993年 | 42篇 |
1992年 | 11篇 |
1991年 | 5篇 |
1990年 | 16篇 |
1989年 | 21篇 |
1988年 | 24篇 |
1987年 | 14篇 |
1986年 | 19篇 |
1985年 | 17篇 |
1984年 | 9篇 |
1983年 | 12篇 |
1982年 | 9篇 |
1981年 | 5篇 |
1980年 | 10篇 |
1979年 | 4篇 |
1978年 | 8篇 |
1977年 | 6篇 |
1976年 | 12篇 |
1975年 | 9篇 |
排序方式: 共有1882条查询结果,搜索用时 24 毫秒
71.
Procedural variation in the performance of primary percutaneous coronary intervention for ST‐elevation myocardial infarction: A SCAI‐based survey study of US interventional cardiologists
下载免费PDF全文
![点击此处可从《Catheterization and cardiovascular interventions》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Austin Chiang MD Hemal Gada MD MBA Susheel K. Kodali MD Michael S. Lee MD Allen Jeremias MD Duane S. Pinto MD MPH Sripal Bangalore MD MHA Robert W. Yeh MD MSc Timothy D. Henry MD Georgina Lopez‐Cruz BS MSHA Roxana Mehran MD Ajay J. Kirtane MD SM 《Catheterization and cardiovascular interventions》2014,83(5):721-726
72.
Lin Zhang Joseph JY Sung Jun Yu Siew C Ng Sunny H Wong Chi H Cho Simon SM Ng Francis KL Chan William KK Wu 《The Journal of pathology》2014,233(2):103-112
Helicobacter pylori and Epstein–Barr virus (EBV) account for roughly 80% and 10%, respectively, of gastric carcinomas worldwide. Autophagy is an evolutionarily conserved and intricately regulated cellular process that involves the sequestration of cytoplasmic proteins and organelles into double‐membrane autophagosomes that eventually fuse with lysosomes for degradation of the engulfed content. Emerging evidence indicates that xenophagy, a form of selective autophagy, plays a crucial role in the pathogenesis of H. pylori‐ and EBV‐induced gastric cancer. Xenophagy specifically recognizes intracellular H. pylori and EBV and physically targets these pathogens to the autophagosomal–lysosomal pathway for degradation. In this connection, H. pylori or EBV‐induced dysregulation of autophagy may be causally linked to gastric tumourigenesis and therefore can be exploited as therapeutic targets. This review will discuss how H. pylori and EBV infection activate autophagy and how these pathogens evade recognition and degradation by the autophagic pathway. Elucidating the molecular aspects of H. pylori‐ and EBV‐induced autophagy will help us better understand the pathogenesis of gastric cancer and promote the development of autophagy modulators as antimicrobial agents. Published by John Wiley & Sons, Ltd 相似文献
73.
74.
Studer V Bobin J Chahid M Mousavi HS Candes E Dahan M 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(26):E1679-E1687
The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware implementations of CS-based acquisition devices--especially in optics--have only started being addressed. This paper presents an implementation of compressive sensing in fluorescence microscopy and its applications to biomedical imaging. Our CS microscope combines a dynamic structured wide-field illumination and a fast and sensitive single-point fluorescence detection to enable reconstructions of images of fluorescent beads, cells, and tissues with undersampling ratios (between the number of pixels and number of measurements) up to 32. We further demonstrate a hyperspectral mode and record images with 128 spectral channels and undersampling ratios up to 64, illustrating the potential benefits of CS acquisition for higher-dimensional signals, which typically exhibits extreme redundancy. Altogether, our results emphasize the interest of CS schemes for acquisition at a significantly reduced rate and point to some remaining challenges for CS fluorescence microscopy. 相似文献
75.
AA Rahsepar A Mirzaee F Moodi M Moohebati S Tavallaie A Eshraghi MS Alavi F Khorashadizadeh H Pourghadamyari R Paydar M Amini R Khojasteh S Mousavi M Sahebi M Ghayour-Mobarhan GA Ferns 《Cardiology》2012,122(4):203-209
Objectives: We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD). Methods: Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients. Results: PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r = -0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05). Conclusion: Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB. 相似文献
76.
77.
78.
79.
Seyyed Mojtaba Mousavi Foo Wah Low Seyyed Alireza Hashemi Nurul Asma Samsudin Mohammad Shakeri Yulisa Yusoff Mansoor Rahsepar Chin Wei Lai Aziz Babapoor Sadaf Soroshnia Su Mei Goh Sieh Kiong Tiong Nowshad Amin 《RSC advances》2020,10(22):12851
Nowadays, chemotherapy is one of the crucial and common therapies in the world. So far, it has been revealed to be highly promising, yet patients suffer from the consequences of severe negative medical dosages. In order to overcome these issues, the enhancement of photothermal chemotherapy with reduced graphene oxide (rGO) as a photothermal agent (PTA) is widely utilised in current medical technologies. This is due to its high near-infrared region (NIR) response, in vitro or in vivo organism biocompatibility, low risk of side effects, and effective positive results. Moreover, rGO not only has the ability to ensure that selective cancer cells have a higher mortality rate but can also improve the growth rate of recovering tissues that are untouched by necrosis and apoptosis. These two pathways are specific diverse modalities of cell death that are distinguished by cell membrane disruption and deoxyribonucleic acid (DNA) disintegration of the membrane via phosphatidylserine exposure in the absence of cell membrane damage. Therefore, this review aimed to demonstrate the recent achievements in the modification of rGO nanoparticles as a PTA as well as present a new approach for performing photochemotherapy in the clinical setting.rGO of QD-rGO nanocomposite could absorb and convert into heat when harvested under NIR radiation, resulting cell death with reduction of fluorescence. 相似文献
80.
Nader Maroufi Amir Ahmadi Seyedeh Roghayeh Mousavi Khatir 《European spine journal》2013,22(1):162-168