赤芝子实体中灵芝酸类成分的研究

自赤芝［Ｇａｎｏｄｅｒｍａｌｕｃｉｄｕｍ（Ｆｒ．）Ｋａｒｓｔ．］子实体的二氯甲烷提取物中分离得到一个新的四环三萜化合物，命名为灵芝酸ＤＭ（ｇａｎｏｄｅｒｉｃａｃｉｄＤＭ，Ｉ）。根据光谱（ＵＶ，ＩＲ，１ＨＮＭＲ，１３ＣＮＭＲ，ＭＳ２ＤＮＭＲ）分析，确定其结构为Ｉ式。同时还分离得到二个已知的灵芝酸类化合物，即灵芝酸Ａ（ｇａｎｏｄｅｒｉｃａｃｉｄＡ，Ｉ）和灵芝酸Ｃ（ｇａｎｏｄｅｒｉｃａｃｉｄＣ，ＩＩ）。     

2,4-二氨基-5-取代苄基嘧啶类化合物的合成及其抑酶活性

本文设计并合成了18个在苄基上带有不同体积取代基的2,4-二氨基-5-取代苄基嘧啶类化合物。测定了这些化合物对乳酪菌二氢叶酸还原酶及对鸡肝二氢叶酸还原酶的表观50%抑制作用。其中2,4-二氨基-5-(3′-羟基-4′-甲氧基)苄基、2,4-二氨基-5-(3′-甲氧基-4′-甲氧乙氧基)苄基嘧啶对上述二氢叶酸还原酶(DHFR)的选择性较好。     

Detailed per-oral small bowel examination vs. enteroclysis. Part II: Radiographic accuracy

Accuracy of the detailed per-oral small bowel series and enteroclysis was compared in 134 patients known to have (or not have) disease of the small bowel. Overall sensitivity of the per-oral examination was 92% and specificity 94%, compared to 94% and 89%, respectively, for enteroclysis. There was no difference between the two in Crohn disease, adhesions, and metastatic disease; however, enteroclysis was thought to be more effective in delineating peritoneal adhesions in patients with obstruction. The authors conclude that while the per-oral study and enteroclysis are equally valid methods of examining the small bowel, the per-oral study is preferable as a screening examination because it requires less time, has fewer side effects, and involves a lower radiation exposure.     

微波和磁疗治疗膝关节骨性关节炎300例

1临床资料①对象:本组骨性关节炎患者300(男130,女170)例,年龄36～78(56±1.0)岁,病程1 mo～10 a,其中左膝120例,右膝112例,双膝68例.临床表现为关节疼痛、僵直、活动受限,偶尔会关节肿胀、关节腔积液.X线表现为关节间隙变窄,关节软骨下骨质致密,骨密度增高,骨小梁有断裂,髁间嵴变尖及髌骨后缘和外侧缘增生形成骨刺[1].     

Antigen-induced changes in odor attractiveness and reproductive output in male mice

Modulation of social signals by antigen-induced immunoenhancement is a significant component of behavioral and reproductive adaptations of a host population to parasitic pressure. To investigate this concept, we studied odor attractiveness and reproductive output of ICR male mice treated with keyhole limpet hemocyanin (KLH) as an antigenic stimulus. We collected urine samples for olfactory preference tests (control vs. KLH administration) on different days following treatment. We found that the differences in odor attractiveness between control and immunized males, which were observed on the 3rd day, disappeared soon afterwards. Odor attractiveness of male mice positively correlated with their immunoresponsiveness, which was assessed by the sum of anti-KLH IgG1 and anti-KLH IgG2a titers. According to the hypothesis of terminal investment, antigen-treated males had higher reproductive output in comparison with control males and produced more progeny as a result.