全文获取类型
收费全文 | 3531篇 |
免费 | 256篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 99篇 |
妇产科学 | 32篇 |
基础医学 | 524篇 |
口腔科学 | 156篇 |
临床医学 | 362篇 |
内科学 | 739篇 |
皮肤病学 | 74篇 |
神经病学 | 344篇 |
特种医学 | 195篇 |
外科学 | 806篇 |
综合类 | 19篇 |
预防医学 | 113篇 |
眼科学 | 30篇 |
药学 | 129篇 |
中国医学 | 5篇 |
肿瘤学 | 139篇 |
出版年
2023年 | 42篇 |
2022年 | 63篇 |
2021年 | 133篇 |
2020年 | 67篇 |
2019年 | 118篇 |
2018年 | 128篇 |
2017年 | 99篇 |
2016年 | 115篇 |
2015年 | 130篇 |
2014年 | 140篇 |
2013年 | 143篇 |
2012年 | 255篇 |
2011年 | 241篇 |
2010年 | 117篇 |
2009年 | 138篇 |
2008年 | 160篇 |
2007年 | 167篇 |
2006年 | 170篇 |
2005年 | 155篇 |
2004年 | 93篇 |
2003年 | 119篇 |
2002年 | 105篇 |
2001年 | 83篇 |
2000年 | 69篇 |
1999年 | 74篇 |
1998年 | 26篇 |
1997年 | 27篇 |
1996年 | 21篇 |
1995年 | 22篇 |
1994年 | 15篇 |
1993年 | 19篇 |
1992年 | 43篇 |
1991年 | 41篇 |
1990年 | 36篇 |
1989年 | 32篇 |
1988年 | 24篇 |
1987年 | 20篇 |
1986年 | 19篇 |
1985年 | 22篇 |
1983年 | 23篇 |
1982年 | 11篇 |
1981年 | 15篇 |
1980年 | 10篇 |
1979年 | 24篇 |
1978年 | 14篇 |
1976年 | 13篇 |
1972年 | 20篇 |
1971年 | 13篇 |
1970年 | 7篇 |
1968年 | 8篇 |
排序方式: 共有3799条查询结果,搜索用时 15 毫秒
991.
992.
Iara B. Rabelo Akemi K. Chiba Elyse Moritz Paulo D'Amora Ismael Dale C. G. Silva Celso A. Rodrigues Melca M. O. Barros José O. Bordin 《British journal of haematology》2023,201(1):140-149
Autoimmune haemolytic anaemia (AIHA) is a rare clinical condition with immunoglobulin fixation on the surface of erythrocytes, with or without complement activation. The pathophysiology of AIHA is complex and multifactorial, presenting functional abnormalities of T and B lymphocytes that generate an imbalance between lymphocyte activation, immunotolerance and cytokine production that culminates in autoimmune haemolysis. In AIHA, further laboratory data are needed to predict relapse and refractoriness of therapy, and thus, prevent adverse side-effects and treatment-induced toxicity. The metabolomic profile of AIHA has not yet been described. Our group developed a cross-sectional study with follow-up to assess the metabolomic profile in these patients, as well as to compare the metabolites found depending on the activity and intensity of haemolysis. We analysed the plasma of 26 patients with primary warm AIHA compared to 150 healthy individuals by mass spectrometry. Of the 95 metabolites found in the patients with AIHA, four acylcarnitines, two phosphatidylcholines (PC), asymmetric dimethylarginine (ADMA) and three sphingomyelins were significantly increased. There was an increase in PC, spermine and spermidine in the AIHA group with haemolytic activity. The PC ae 34:3/PC ae 40:2 ratio, seen only in the 12-month relapse group, was a predictor of relapse with 81% specificity and 100% sensitivity. Increased sphingomyelin, ADMA, PC and polyamines in patients with warm AIHA can interfere in autoantigen and autoimmune recognition mechanisms in a number of ways (deficient action of regulatory T lymphocytes on erythrocyte recognition as self, negative regulation of macrophage nuclear factor kappa beta activity, perpetuation of effector T lymphocyte and antibody production against erythrocyte antigens). The presence of PC ae 34:3/PC ae 40:2 ratio as a relapse predictor can help in identifying cases that require more frequent follow-up or early second-line therapies. 相似文献
993.
Matthew Ho Saurabh Zanwar Francis K. Buadi Sikander Ailawadhi Jeremy Larsen Leif Bergsagel Moritz Binder Asher Chanan-Khan David Dingli Angela Dispenzieri Rafael Fonseca Morie A. Gertz Wilson Gonsalves Ronald S. Go Suzanne Hayman Prashant Kapoor Taxiarchis Kourelis Martha Q. Lacy Nelson Leung Yi Lin Eli Muchtar Vivek Roy Taimur Sher Rahma Warsame Amie Fonder Miriam Hobbs Yi L. Hwa Robert A. Kyle S. Vincent Rajkumar Shaji Kumar 《American journal of hematology》2023,98(1):49-55
Patients with multiple myeloma (MM) have a lower efficacy from COVID-19 vaccination and a high rate of mortality from COVID-19 in hospitalized patients. However, the overall rate and severity of COVID-19 infection in all settings (including non-hospitalized patients) and the independent impact of plasma cell-directed therapies on outcomes needs further study. We reviewed the medical records of 9225 patients with MM or AL amyloidosis (AL) seen at Mayo Clinic Rochester, Arizona, and Florida between 12/01/2019 and 8/31/2021 and identified 187 patients with a COVID-19 infection (n = 174 MM, n = 13 AL). The infection rate in our cohort was relatively low at 2% but one-fourth of the COVID-19 infections were severe. Nineteen (10%) patients required intensive care unit (ICU) admission and 5 (3%) patients required mechanical ventilation. The mortality rate among hospitalized patients with COVID-19 was 22% (16/72 patients). Among patients that were fully vaccinated at the time of infection (n = 12), two (17%) developed severe COVID-19 infection, without any COVID-related death. On multivariable analysis, treatment with CD38 antibody within 6 months of COVID-19 infection [Risk ratio (RR) 3.6 (95% CI: 1.2, 10.5), p = .02], cardiac [RR 4.1 (95% CI: 1.3, 12.4), p = .014] or pulmonary comorbidities [RR 3.6 (95% CI 1.1, 11.6); p = .029] were independent predictors for ICU admission. Cardiac comorbidity [RR 2.6 (95% CI: 1.1, 6.5), p = .038] was an independent predictor of mortality whereas MM/AL in remission was associated with lower mortality [RR 0.4 (95% CI: 0.2–0.8); p = .008]. 相似文献
994.
Die Onkologie - Weichgewebesarkome sind seltene Tumoren. In bis zu 50?% der Fälle treten Tumorrückfälle auf. Aufgrund der unterschiedlichen histologischen Subtypen,... 相似文献
995.
996.
997.
998.
Moritz Weigl Roland Kocijan James Ferguson Gabriele Leinfellner Patrick Heimel Xaver Feichtinger Peter Pietschmann Johannes Grillari Jochen Zwerina Heinz Redl Matthias Hackl 《Journal of bone and mineral research》2021,36(6):1131-1144
MicroRNAs regulate bone homeostasis, and circulating microRNAs have been proposed as novel bone biomarkers. The effect of anti-osteoporotic treatment on circulating microRNAs has not been described in detail. Therefore, we performed a comprehensive analysis of microRNA serum levels in ovariectomized (OVX) and sham-operated (SHAM) rats over 12 weeks of antiresorptive or osteoanabolic treatment. Forty-two Sprague Dawley rats underwent SHAM surgery (n = 10) or ovariectomy (n = 32). After 8 weeks, OVX rats were randomized to antiresorptive treatment with zoledronate (n = 11), osteoanabolic treatment with teriparatide (n = 11), or vehicle treatment (n = 10). Serum samples were collected at weeks 8, 12, 16, and 20 after surgery. A total of 91 microRNAs were analyzed by RT-qPCR in serum samples collected at week 20. Based on the results, 29 microRNAs were selected for longitudinal analysis at all four study time points. Changes in bone mineral density and microstructure were followed up by in vivo micro-CT and ex vivo nano-CT. Ovariectomy resulted in the loss of trabecular bone, which was reversed by osteoanabolic and antiresorptive treatment. Differential expression analysis identified 11 circulating miRNAs that were significantly regulated after treatment. For example, miR-107 and miR-31-5p increased in vehicle-treated OVX animals, whereas they decreased during teriparatide treatment. Additional miRNAs were identified that showed significant correlations to bone microstructure or bone miRNA expression, including miR-203a-3p, which exhibited a significant negative correlation to vertebral and tibial trabecular bone volume fraction (%). Longitudinal analysis confirmed eight microRNAs with significant changes in serum over time that were prevented by teriparatide and zoledronate treatment (miR-34a-5p, miR-31-5p, miR-30d-3p, miR-378a-5p) or teriparatide treatment only (miR-375-3p, miR-183-5p, miR-203a-3p, miR-203b-3p). Gene target network analysis identified WNT and Notch signaling as the main signaling pathways controlled by these miRNAs. Thus, ovariectomy results in time-dependent deregulation of circulating miRNAs compared with SHAM animals. Anti-osteoporotic treatments can rescue this effect, showing that bone-related miRNAs might act as novel biomarkers for treatment monitoring. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). 相似文献
999.
1000.
Guadalupe Antelo Abhishek A. Mangaonkar Giacomo Coltro Ajinkya Buradkar Terra L. Lasho Christy Finke Ryan Carr Moritz Binder Naseema Gangat Aref Al-Kali Michelle A. Elliott Rebecca L. King Matthew Howard Megan E. Melody William Hogan Mark R Litzow Ayalew Tefferi Martin E. Fernandez-Zapico Rami Komrokji Mrinal M. Patnaik 《British journal of haematology》2020,189(3):e104-e108