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91.
J. Renata Ochocka Monika Asztemborska Danuta Sybilska Wioletta Langa 《Pharmaceutical biology》2013,51(5):395-399
The enantiomeric contents of monoterpenes have been determined in essential oils from the following species: Pinus cembra, Pinus nigra, Pinus pinaster, Pinus montana, Pinus sylvestris, Abies alba and Abies sibirica. A gas chromatographic method with a formamide solution of a-cyclodextrin as a stationary phase was applied for the separation and determination of enantiomers. 相似文献
92.
Monika Chopra H. S. Rehan Rachna Gupta F. J. Ahmad M. D. Tariq L. K. Gupta 《Indian journal of pharmaceutical sciences》2014,76(5):462-465
For the prevention of postoperative ocular infections prophylactic topical antibiotics are routinely used. Studies evaluating comparative difference between single dose versus multiple dose administration on aqueous humour concentration of moxifloxacin are lacking. This study compared the aqueous humour concentration of moxifloxacin following its topical administration in rabbit eyes with two dose regimens. Twelve albino rabbits were divided into two groups. In group-1, two drops were administered thrice (total six drops) at 2 min intervals, in both the eyes; in group-2, two drops of moxifloxacin were administered three times a day for three days and also two h before aqueous humour collection i.e. on fourth day. Mean aqueous humour concentrations were calculated and compared using Student''s ‘t’ test and P<0.05 was considered significant. Moxifloxacin concentration in aqueous humour in group-1 was 23.79 μg/ml and in group-2 was 42.08 μg/ml. Both dosing regimens produced substantially higher aqueous concentrations than the known minimum inhibitory concentration for most bacteria. Moxifloxacin concentration in aqueous humour with multiple instillations is significantly higher than single instillation (P<0.05), which is adequate to cover ciprofloxacin-resistant gram-negative bacteria. Repeated topical moxifloxacin administration achieved significantly higher aqueous humour concentrations than single administration. 相似文献
93.
Plasma renin concentration represents an independent risk factor for mortality and is associated with liver dysfunction in patients with cirrhosis 下载免费PDF全文
94.
Monika Drobna Bronisława Szarzyńska-Zawadzka Małgorzata Dawidowska 《Blood reviews》2018,32(6):457-472
T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive and heterogeneous malignancy originating from T-cell precursors. The mechanisms of T-ALL pathogenesis related to non-protein coding part of the genome are currently intensively studied. miRNAs are short, non-coding molecules acting as negative regulators of gene expression which shape phenotype of cells in a complex and context-specific manner. miRNAs may act as oncogenes or tumor suppressors; several miRNAs have been related to drug resistance and treatment response in various malignancies.Here we present the review of the state-of-the-art knowledge on the role of miRNAs in T-ALL pathogenesis, with detailed overview of the studies reporting on miRNAs with oncogenic and tumor suppressor potential. We discuss whether miRNAs might be considered candidate biomarkers of prognosis in T-ALL and leukemia subtype-specific markers. We also describe experimental approaches and a typical workflow applied in research on the involvement of miRNAs in oncogenesis. 相似文献
95.
Differential expression of homologous recombination DNA repair genes in the early and advanced stages of myelodysplastic syndrome 下载免费PDF全文
96.
97.
Miriam Nannette Ebert Gabriele Beyer-Sehlmeyer Ute Monika Liegibel Tanja Kautenburger Thomas Walter Becker Beatrice Louise Pool-Zobel 《Nutrition and cancer》2013,65(1-2):156-164
Butyrate, one of the major products of gut fermentation, is known to inhibit proliferation, induce apoptosis and differentiation, and increase phase II enzyme activities in tumor cells, whereas little information is available on protective effects in less-transformed colon cells. The aim of this study was to investigate whether the chemoprotective mechanism of glutathione S-transferase (GST) induction by butyrate could also play a role in earlier stages of colon carcinogenesis and whether chemoresistance of cells toward the endogenous genotoxic risk factor 4-hydroxy-2-nonenal (HNE) could be a consequence of butyrate treatment. As cell models, we used the human tumor cell lines HT29 and HT29 clone 19A, a differentiated subclone with properties resembling primary colon cells. We determined the expression of GSTP1 protein (enzyme-linked immunosorbent assay), the major GST in HT29, GSTP1 mRNA (Northern blotting), GST activity, intracellular glutathione, and total protein. The genotoxic impact of HNE (100-200 μM) was compared in butyrate-treated and nontreated cells using single-cell microgel electrophoresis. Our results show that GSTP1 mRNA, GSTP1 protein, GST activity, and total protein were increased (1.2- to 2.5-fold) and glutathione levels were maintained after 24- 72 h of incubation with 4 mM butyrate. Moreover, a marked reduction of HNE-induced genotoxicity was caused by preincubation with butyrate. Butyrate also induced the phosphorylation of extracellular signal-regulated kinases (ERK1/2, Western blotting) after 5-30 min, which indicates a regulation of GST expression by this signal pathway. Most effects were greater in HT29 parent cells than in clone cells. In conclusion, butyrate enhances expression of GST and other proteins in both cell lines, which leads to an enhanced chemoprotection, reducing the impact of HNE genotoxicity. Thus butyrate could play a role in early and later stages of cancer prevention by reducing exposure to relevant risk factors. 相似文献
98.
Denis A. Mogilenko Oleg Shpynov Prabhakar Sairam Andhey Laura Arthur Amanda Swain Ekaterina Esaulova Simone Brioschi Irina Shchukina Martina Kerndl Monika Bambouskova Zhangting Yao Anwesha Laha Konstantin Zaitsev Samantha Burdess Susan Gillfilan Sheila A. Stewart Marco Colonna Maxim N. Artyomov 《Immunity》2021,54(1):99-115.e12
99.
100.
Between diverging discourses of the child: juveniles’ self-construction in coercive residential care
Monika Alvestad Reime 《Child Care in Practice》2018,24(3):273-287
Based on a qualitative study, this article explores how Norwegian juveniles construct themselves through stories of everyday life in coercive residential care and how this is related to diverging discourses of the child’s status in society. The findings reveal two dominant positions of identification—the autonomy position and the responsibility position—which are discussed as made possible by the child-as-citizen discourse. The article argues that juveniles self-constructions primarily contrast but also are intervened with the dominant discourse of the vulnerable child in social work. The article concludes that recognising juveniles’ in residential care as citizens implies a critical evaluation of practices inherent in the discourse of the vulnerable child. 相似文献