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111.
Hada Sonal Yadav Dinesh Kumar Roat Priyanka Kumari Neetu 《Pharmaceutical Chemistry Journal》2020,54(1):40-45
Pharmaceutical Chemistry Journal - Eulophia nuda Lindl. (Orchidaceae) is a small perennial terrestrial herb found in central and Southeast Asian regions usually known for its ethnomedicinal uses by... 相似文献
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D. Kishorkumar P. Stalin R. Vishnu Prasad Zile Singh J. P. Tripathy A. Sharma S. Prinja Vijay Gupta Victoria Job Niranjan Thomas Nalinikant Panigrahy Poddutoor Preetham Kumar Dinesh Kumar Chirla Shivanarayan Reddy Vennapusa M. Noll P. R. S. Noll E. M. Santos A. R. Silva Neto C. T. Candotti Pankaj Kumar Mohanty Karthik Nagesh N Abdul Razak 《Indian pediatrics》2016,53(2):165-172
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Isolation of a lytic bacteriophage against virulent Aeromonas hydrophila from an organized equine farm 下载免费PDF全文
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Huang-Chi Wang Hsin-Sheng Tsay Hui-Nung Shih Yi-An Chen Kai-Ming Chang Dinesh Chandra Agrawal 《Pharmaceutical biology》2018,56(1):124-131
Context: Andrographolide (Andro), found in large quantities in Andrographis paniculata Nees (Acanthaceae), is anti-inflammatory, especially in the central nervous system (CNS) glia.Objective: The objective of this study is to test Andro’s ability to reduce allodynia in a spared nerve injury model.Material and methods: Male 30?g BalbC mice were divided into four groups: (1) Sham-operated control (Sham-group); (2) nerve injured and treated with saline (Saline-group); (3) nerve injured and treated with Andro (Andro-group); (4) nerve injured and treated with non-steroidal anti-inflammatory drugs (NSAIDS) (NSAIDS-group). Andro or NSAIDS (diclofenac salt) were injected intraperitoneally at 5?mg/kg body weight daily. Mechanical allodynia was assessed by von Frey tests at 3, 7, and 14?d. For immunohistochemical analysis, samples were collected at 7?d.Results: The threshold for inducing allodynia increased and the response percentage reduced in the Andro-group when compared with the Saline-group, as well as when compared with NSAIDS groups throughout 3–14?d. The ratio of threshold for OP-Andro/OP-saline and for OP-Andro/OP-NSAIDS groups was 20.42 and 11.67 at 14?d, respectively. The ratio of response percentage for OP-Andro/OP-saline and for OP-Andro/OP-NSAIDS was 0.32 and 0.39 at 14?d, respectively. Interleukin-1 (IL-1) immunostaining in the spinal cord was reduced in the Andro-group. Astrocytic activities were not significantly reduced in the Andro-group compared with the Saline-group at 7?d post-operation (PO)Conclusions: Andro reduced mechanical allodynia more than NSAIDS at the same concentration, and the observed behaviour was associated with a reduction in inflammatory cytokine produced in the spinal cord. 相似文献
117.
Dinesh K. Mishra Ruchita Shandilya Pradyumna K. Mishra 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(7):2023-2050
Over the recent couple of decades, pharmaceutical field has embarked most phenomenal noteworthy achievements in the field of medications as well as drug delivery. The rise of Nanotechnology in this field has reformed the existing drug delivery for targeting, diagnostic, remedial applications and patient monitoring. The convincing usage of nanotechnology in the conveyance of medications that prompts an extension of novel lipid-based nanocarriers and non-liposomal systems has been discussed. Present review deals with the late advances and updates in lipidic nanocarriers, their formulation strategies, challenging aspects, stability profile, clinical applications alongside commercially available products and products under clinical trials. This exploration may give a complete idea viewing the lipid based nanocarriers as a promising choice for the formulation of pharmaceutical products, the challenges looked by the translational process of lipid-based nanocarriers and the combating methodologies to guarantee the headway of these nanocarriers from bench to bedside. 相似文献
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European Spine Journal - 相似文献
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Maruthanayagam Veerabadhran Nagarajan Manivel Dinesh Mohanakrishnan 《Pharmaceutical biology》2014,52(10):1291-1301
Context: Marine cyanobacteria offer considerable potential to isolate new antimalarials to meet a pressing need of our times.Objective: To explore the antiplasmodial properties of marine cyanobacteria.Materials and methods: Cyanobacterial samples collected from the coastal regions of Tamil Nadu were identified using light microscopy, and the strains were cultivated in ASN-III medium. Organic extracts (0–100?µg?mL?1) of 25 in vitro mass-cultivated cyanobacteria, prepared using methanol: chloroform mixture (1:1?v/v) were evaluated for their antiplasmodial activity against chloroquine-sensitive and -resistant strains of Plasmodium falciparum by fluorescence-based SYBR Green I assay where chloroquine was used as a control. To detect the toxic effects of cyanobacterial extracts against red blood cells, the invasion, maturation, and growth rate of malarial parasites in cyanobacterial extracts pre-treated versus untreated erythrocytes were quantified microscopically. Mammalian cell line (HeLa) was used to determine cyanobacterial extract toxicity using the MTT assay.Results: The extracts of Lyngbya aestuarii Liebm. ex Gomont CNP 1005 (C12) Oscillatoria boryana BDU 91451 (C22) and Oscillatoria boryana Bory ex Gomont BDU 141071 (C18) showed promising antiplasmodial activity (IC50?=?18, 18, and 51?μg?mL?1 respectively) against Pf3D7. Pretreatment of red blood cells with IC100 of C12, C18, and C22 (40, 100, and 40?µgmL?1, respectively) did not significantly influence the invasion, maturation, and growth rate of malarial parasites in comparison with untreated RBC controls suggesting a lack of toxicity to host cells. MTT assay based IC50 (>200?μg?mL?1) of these extracts against HeLa cell line also indicates their high selectivity against the malaria parasite.Discussion and conclusion: These exploratory studies suggest the possibilities of development of new antimalarial compounds from marine cyanobacteria. 相似文献