全文获取类型
收费全文 | 958篇 |
免费 | 71篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 13篇 |
妇产科学 | 10篇 |
基础医学 | 81篇 |
口腔科学 | 15篇 |
临床医学 | 60篇 |
内科学 | 306篇 |
皮肤病学 | 2篇 |
神经病学 | 39篇 |
特种医学 | 37篇 |
外科学 | 255篇 |
综合类 | 14篇 |
一般理论 | 1篇 |
预防医学 | 19篇 |
眼科学 | 8篇 |
药学 | 85篇 |
1篇 | |
肿瘤学 | 82篇 |
出版年
2022年 | 8篇 |
2021年 | 11篇 |
2020年 | 5篇 |
2019年 | 10篇 |
2018年 | 11篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 8篇 |
2014年 | 15篇 |
2013年 | 13篇 |
2012年 | 37篇 |
2011年 | 36篇 |
2010年 | 15篇 |
2009年 | 20篇 |
2008年 | 38篇 |
2007年 | 36篇 |
2006年 | 27篇 |
2005年 | 19篇 |
2004年 | 18篇 |
2003年 | 22篇 |
2002年 | 48篇 |
2001年 | 27篇 |
2000年 | 27篇 |
1999年 | 11篇 |
1998年 | 10篇 |
1997年 | 6篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1992年 | 67篇 |
1991年 | 59篇 |
1990年 | 53篇 |
1989年 | 44篇 |
1988年 | 38篇 |
1987年 | 26篇 |
1986年 | 35篇 |
1985年 | 28篇 |
1984年 | 19篇 |
1983年 | 17篇 |
1982年 | 19篇 |
1981年 | 10篇 |
1980年 | 6篇 |
1979年 | 16篇 |
1978年 | 8篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1971年 | 5篇 |
1968年 | 13篇 |
1967年 | 10篇 |
1966年 | 5篇 |
排序方式: 共有1029条查询结果,搜索用时 15 毫秒
61.
62.
63.
Isoflavone aglycone-rich extract without soy protein attenuates atherosclerosis development in cholesterol-fed rabbits 总被引:17,自引:0,他引:17
Yamakoshi J Piskula MK Izumi T Tobe K Saito M Kataoka S Obata A Kikuchi M 《The Journal of nutrition》2000,130(8):1887-1893
The antiatherogenic effect of soy protein with intact isoflavones is well established, but the effects of isoflavones without soy protein have not been determined. We investigated the antiatherogenic effect of an isoflavone aglycone-rich extract (containing 429.4 mg/g isoflavone aglycones) without soy protein from fermented soy in cholesterol-fed rabbits. We fed 12-wk-old New Zealand white male rabbits diets containing 1 g/100 g cholesterol with 0, 0.33 or 1 g/100 g isoflavone aglycones for 8 wk. We also fed the rabbits a diet containing 1 g/100 g cholesterol with 1.09 g/100 g soy saponin-rich extract, a component other than isoflavone aglycones in the isoflavone aglycone-rich extract. Controls did not consume cholesterol, isoflavone aglycones or saponins. The isoflavone aglycone- and saponin-rich extracts did not affect the serum lipid profile of cholesterol-fed rabbits. The serum concentration of daidzein in its conjugated form was significantly higher in the high isoflavone group than in the low isoflavone group. The level of cholesteryl ester hydroperoxide (ChE-OOH) induced by CuSO(4) in plasma in the high isoflavone group was significantly less than that in the cholesterol group, and the ChE-OOH levels of LDL in the low and high isoflavone groups were significantly less than those in the cholesterol group. The ChE-OOH levels in plasma and LDL in the saponin group did not differ from the cholesterol group. In the aortic arch, the cholesterol concentration was significantly lower in the high isoflavone group, and malondialdehyde concentration was significantly lower in the low and high isoflavone groups compared with the cholesterol group; however these concentrations in the saponin group did not differ from those in the cholesterol group. The atherosclerotic lesion area of the aortic arch was significantly lower in the isoflavone groups (26.3% lower in the low isoflavone group and 36.9% lower in the high isoflavone group) than in the cholesterol group. The lesion areas were not different in the soy saponin and cholesterol groups. Immunohistochemical analysis revealed fewer oxidized LDL-positive macrophage-derived foam cells in atherosclerotic lesions in the aortic arch of isoflavone groups compared with that of the cholesterol group. These results suggest that the antioxidative action of isoflavones and their antioxidative metabolites inhibit the oxidation of LDL, thereby exerting an antiatherosclerotic effect. 相似文献
64.
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes 总被引:1,自引:0,他引:1 下载免费PDF全文
65.
66.
67.
In order to examine the toxic effects on the pancreas of oxygen free radicals which are generated at reperfusion after ischemia, a short term-ischemia/reperfusion model was prepared in rats. Both the anterior mesenteric artery and the celiac artery were ligated and then released to restore blood flow. In a group where the anterior mesenteric and the celiac arteries were ligated for 60 minutes, the serum levels of amylase and lipase rose 7 and 6 times, respectively, 7 hours after reperfusion. In a group ligated for 30 minutes, both levels remained unchanged. Histologically, vacuolization of the pancreatic acinar cells was observed, only in a group rats ischemic for 7 hours. In rats ligated for 60 minutes with a continuous venous infusion of superoxide dismutase (SOD) (3600 U/Kg/hour), the secretion of amylase and lipase decreased to 25 percent of that in the non-injected group. These results confirm that the oxygen free radicals, which are generated by the short term-ischemia/reperfusion method, injure the pancreas. This may lead to pancreatitis with hyperamylasemia and hyperlipasemia. Pretreatment with an active oxygen scavenger, SOD, markedly reduces the rise in serum amylase and lipase levels. This suggests that active oxygen free radicals are involved in the pathogenesis of acute pancreatitis. 相似文献
68.
K Matsumoto A Usui T Ochiai K Sekita Y Kawasaki K Naito Y Nakaji T Furuya M Tobe 《The Journal of toxicological sciences》1986,11(4):293-301
The marmoset, a small non-human primate, has rarely been used in toxicological studies. A short-term toxicity study was performed on common marmosets (BW = 330 +/- 32 g). Fifteen male marmosets received oral administration of DAB at a dose level of 56 mg/kg/day and 4 control animals received corn oil alone for a period of 15 days. Hematological, biochemical, histopathological and bone marrow examinations were carried out on the 5th, 10th and 15th day of treatment. Body weight decreased continuously and two animals died on day 10. Decreases in RBC, Hb and Ht and increases in MCV and WBC were observed. Uric acid and glucose were increased and AlP and LAP were decreased. Aldolase, GOT and GPT were increased by day 10, and thereafter recovery of aldolase to the control level and decreases of GOT and GPT were observed. Relative organ weights of the liver, kidney, spleen and adrenal were increased. Histologically, C-cell hyperplasia of the thyroid and slight changes of the liver were noted. Marrow total cell counts were not changed, but the G/E ratio was reduced. Thus, macrocytic anemia, an increase of marrow erythroblasts due to anemia and changes of biochemical parameters indicating liver injury were observed in marmosets; these findings were similar to those in rats in the previous experiments. 相似文献
69.
C C Tseng Y Nio T Shiraishi M Tsubono H Morimoto K Kawabata Y Masai T Tun M Fukumoto T Tobe 《Anti-cancer drugs》1991,2(5):457-464
Two human gastric cancer xenograft lines (GC-YN and GC-SF) transplanted in nude mice were employed to evaluate and compare the anticancer effect of seven single anticancer agents and their various combinations. Mitomycin C, cisplatin (Briplatin) (CDDP) and 5-fluorouracil (5-FU) were screened out to be effective against GC-YN and only epirubicin (Farmorubicin) (EPIR) was effective against GC-SF. Combinations of two of these 'effective' agents revealed that FP (5-FU + CDDP) is the most effective two-agent combination regimen against both lines, and some of those 'ineffective' single agents showed synergistic effects against both lines when combined with 5-FU. Moreover, three-agent combinations composed of FP and one of the other five agents were also evaluated to select out the most effective regimen. All the combinations showed higher inhibition on the tumor growth of GC-YN than FP regimen, and FP + adriamycin (Adriacin) (ADR) and FP + EPIR were more effective against GC-SF than FP. However, taking toxic effects into consideration, the results suggest that CDDP + 5-FU + EPIR (FPEPIR) may be the regimen most worthy of clinical trial in the chemotherapy against human gastric cancer. 相似文献
70.