全文获取类型
收费全文 | 1403篇 |
免费 | 120篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 70篇 |
妇产科学 | 27篇 |
基础医学 | 151篇 |
口腔科学 | 46篇 |
临床医学 | 145篇 |
内科学 | 355篇 |
皮肤病学 | 28篇 |
神经病学 | 58篇 |
特种医学 | 129篇 |
外科学 | 189篇 |
综合类 | 28篇 |
预防医学 | 81篇 |
眼科学 | 26篇 |
药学 | 58篇 |
肿瘤学 | 120篇 |
出版年
2021年 | 23篇 |
2020年 | 16篇 |
2018年 | 23篇 |
2017年 | 21篇 |
2016年 | 19篇 |
2015年 | 24篇 |
2014年 | 42篇 |
2013年 | 60篇 |
2012年 | 32篇 |
2011年 | 48篇 |
2010年 | 45篇 |
2009年 | 38篇 |
2008年 | 49篇 |
2007年 | 55篇 |
2006年 | 58篇 |
2005年 | 48篇 |
2004年 | 40篇 |
2003年 | 27篇 |
2002年 | 43篇 |
2001年 | 26篇 |
2000年 | 26篇 |
1999年 | 42篇 |
1998年 | 36篇 |
1997年 | 42篇 |
1996年 | 41篇 |
1995年 | 29篇 |
1994年 | 26篇 |
1993年 | 21篇 |
1992年 | 24篇 |
1991年 | 15篇 |
1990年 | 15篇 |
1989年 | 17篇 |
1988年 | 22篇 |
1987年 | 22篇 |
1986年 | 33篇 |
1985年 | 24篇 |
1984年 | 23篇 |
1982年 | 21篇 |
1980年 | 17篇 |
1978年 | 15篇 |
1977年 | 22篇 |
1976年 | 14篇 |
1975年 | 21篇 |
1974年 | 27篇 |
1973年 | 21篇 |
1972年 | 24篇 |
1971年 | 23篇 |
1970年 | 19篇 |
1968年 | 15篇 |
1966年 | 14篇 |
排序方式: 共有1533条查询结果,搜索用时 15 毫秒
21.
Female sterilisation is an important component of National Family Welfare Programme. The target group is best motivated during the puerperium for such a procedure. However laparoscopic sterilisation which has got some distinct advantages, is not technically feasible at this time. The authors have used a technique where the advantages of cosmetic appearance, reduced post operative morbidity and reversibility can be conferred on the puerperal women.After trying out the method individually in some cases, a formal case control study design has been made and an evaluation study has been performed in 122 cases. The technique has been found to be cosmetically more acceptable, both at clientele and peer evaluation levels (p<0.001). Though all the four parameters of post operative morbidity have shown better results for the technique evaluated as against the conventional technique, statistical significance has been achieved in two of the parameters (p<0.05).KEY WORDS: Cosmetics, Female sterilisation, Post operative morbidity 相似文献
22.
J Moller 《Injury prevention》2004,10(1):2-3
23.
Severus E Seemuller F Berger M Dittmann S Obermeier M Pfennig A Riedel M Frangou S Moller HJ Bauer M 《BMC medicine》2012,10(1):67
ABSTRACT: BACKGROUND: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression. However, the blinded use of placebo has been found to influence clinical trial outcome and may bias patient selection. DISCUSSION: To improve clinical trial design in major depression so as to reflect clinical practice more closely we propose to present patients with a balanced view of the benefits of study participation irrespective of the assignment to placebo or active treatment. In addition every participant should be given the option to finally receive the active medication. A research agenda is outlined to evaluate the impact of the proposed changes on the efficacy of the drug to be evaluated and on the demographic and clinical characteristics of the enrolment fraction with regard to its representativeness of the eligible population. SUMMARY: We propose a list of measures to be taken to improve the external validity of double-blind, placebo-controlled trials in major depression. The recommended changes to clinical trial design may also be relevant for other psychiatric as well as medical disorders in which expectations regarding treatment outcome may affect the outcome itself. 相似文献
24.
Jeffrey M. Vinocur Jeremiah S. Menk John Connett James H. Moller Lazaros K. Kochilas 《Pediatric cardiology》2013,34(5):1226-1236
Mortality after pediatric cardiac surgery varies among centers. Previous research suggests that surgical volume is an important predictor of this variation. This report characterizes the relative contribution of patient factors, center surgical volume, and a volume-independent center effect on early postoperative mortality in a retrospective cohort study of North American centers in the Pediatric Cardiac Care Consortium (up to 500 cases/center/year). From 1982 to 2007, 49 centers reported 109,475 operations, 85,023 of which were analyzed using hierarchical multivariate logistic regression analysis. Patient characteristics varied significantly among the centers. The adjusted odds ratio (OR) for mortality decreased more than 10-fold during the study period (1982 vs. 2007: OR, 12.27, 95 % confidence interval [CI], 8.52–17.66; p < 0.0001). Surgical volume was associated inversely with odds of death (additional 100 cases/year: OR, 0.84; 95 % CI, 0.78–0.90; p < 0.0001). In the analysis of interactions, this effect was fairly consistent across age groups, risk categories (except the lowest), and time periods. However, a volume-independent center effect contributed substantially more to the risk model than did the volume. The Risk Adjusted Classification for Congenital Heart Surgery, version 1 (RACHS-1) risk category remains the strongest predictor of postoperative mortality through the 25-year study period. In conclusion, center-specific variation exists but is only partially explained by operative volume. Low-risk operations are safely performed at centers in all volume categories, whereas regionalization or other quality improvement strategies appear to be warranted for moderate- and high-risk operations. Potentially preventable mortality occurs at centers in all volume categories studied, so referral or regionalization strategies must target centers by observed outcomes rather than assume that volume predicts quality. 相似文献
25.
Maria B Sukkar Md Ashik Ullah Wan Jun Gan Peter AB Wark Kian Fan Chung J Margaret Hughes Carol L Armour Simon Phipps 《British journal of pharmacology》2012,167(6):1161-1176
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous inflammatory disorders of the respiratory tract characterized by airflow obstruction. It is now clear that the environmental factors that drive airway pathology in asthma and COPD, including allergens, viruses, ozone and cigarette smoke, activate innate immune receptors known as pattern-recognition receptors, either directly or indirectly by causing the release of endogenous ligands. Thus, there is now intense research activity focused around understanding the mechanisms by which pattern-recognition receptors sustain the airway inflammatory response, and how these mechanisms might be targeted therapeutically. One pattern-recognition receptor that has recently come to attention in chronic airways disease is the receptor for advanced glycation end products (RAGE). RAGE is a member of the immunoglobulin superfamily of cell surface receptors that recognizes pathogen- and host-derived endogenous ligands to initiate the immune response to tissue injury, infection and inflammation. Although the role of RAGE in lung physiology and pathophysiology is not well understood, recent genome-wide association studies have linked RAGE gene polymorphisms with airflow obstruction. In addition, accumulating data from animal and clinical investigations reveal increased expression of RAGE and its ligands, together with reduced expression of soluble RAGE, an endogenous inhibitor of RAGE signalling, in chronic airways disease. In this review, we discuss recent studies of the ligand–RAGE axis in asthma and COPD, highlight important areas for future research and discuss how this axis might potentially be harnessed for therapeutic benefit in these conditions. 相似文献
26.
Hand‐foot‐skin reaction related to use of the multikinase inhibitor sorafenib and hard orthotics
下载免费PDF全文
![点击此处可从《Pediatric dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ayan Kusari MA Jenna Borok MAS Allison M. Han AB Alix Jessika Valderrama MD Sheila Fallon Friedlander MD 《Pediatric dermatology》2018,35(4):e206-e209
Hand‐foot‐skin reaction is a distinct clinical condition arising in association with the use of multikinase inhibitors, including sorafenib. Because multikinase inhibitors are increasingly being used in children with cancer, recognition of this previously unfamiliar condition is of importance to pediatric dermatologists. We describe the diagnosis and successful treatment of a case of hand‐foot‐skin reaction in a child taking sorafenib for an unresectable desmoid tumor. 相似文献
27.
Logan G. Spector Jeremiah S. Menk Jessica H. Knight Courtney McCracken Amanda S. Thomas Jeffrey M. Vinocur Matthew E. Oster James D. St Louis James H. Moller Lazaros Kochilas 《Journal of the American College of Cardiology》2018,71(21):2434-2446
Background
Congenital heart surgery has improved the survival of patients with even the most complex defects, but the long-term survival after these procedures has not been fully described.Objectives
The purpose of this study was to evaluate the long-term survival of patients (age <21 years) who were operated on for congenital heart defects (CHDs).Methods
This study used the Pediatric Cardiac Care Consortium data, a U.S.-based, multicenter registry of pediatric cardiac surgery. Survival analysis included 35,998 patients who survived their first congenital heart surgery at <21 years of age and had adequate identifiers for linkage with the National Death Index through 2014. Survival was compared to that in the general population using standardized mortality ratios (SMRs).Results
After a median follow-up of 18 years (645,806 person-years), 3,191 deaths occurred with an overall SMR of 8.3 (95% confidence interval [CI]: 8.0 to 8.7). The 15-year SMR decreased from 12.7 (95% CI: 11.9 to 13.6) in the early era (1982 to 1992) to 10.0 (95% CI: 9.3 to 10.8) in the late era (1998 to 2003). The SMR remained elevated even for mild forms of CHD such as patent ductus arteriosus (SMR 4.5) and atrial septal defects (SMR 4.9). The largest decreases in SMR occurred for patients with transposition of great arteries (early: 11.0 vs. late: 3.8; p < 0.05), complete atrioventricular canal (31.3 vs. 15.3; p < 0.05), and single ventricle (53.7 vs. 31.3; p < 0.05).Conclusions
In this large U.S. cohort, long-term mortality after congenital heart surgery was elevated across all forms of CHD. Survival has improved over time, particularly for severe defects with significant changes in their management strategy, but still lags behind the general population. 相似文献28.
Jaime Caro Alexandra Ward Jorgen Moller 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2006,8(6):449-455
AIMS: To estimate the consequences of managing bradycardia due to sinoatrial node disease or atrioventricular block with dual-chamber vs. single-chamber ventricular pacemakers. METHODS AND RESULTS: A discrete-event simulation was conducted to predict outcomes over 5 years. Patients could develop post-operative complications, clinically relevant pacemaker syndrome leading to replacement of single-chamber with dual-chamber, atrial fibrillation (AF; which if chronic might require anticoagulants) or stroke. Survival, quality-adjusted life years (QALYs), complications, and associated direct medical costs were estimated (2003 British Pounds pounds sterling). Identical patients were simulated after receiving a single-chamber device or a more expensive dual-chamber pacemaker. Probabilities of conditions were obtained from clinical trials. Benefits were discounted at 1.5% and costs at 6%. Post-operative complications increased from 6.4% with single-chamber to 7.7% with dual-chamber but AF decreased (22 vs. 18%) as did clinically relevant pacemaker symptoms (16.8 vs. 0%). Approximately 4300 pounds sterling were accrued per patient over 5 years. Additional health benefits with dual-chamber are achieved at a mean net cost of 43 pounds sterling per patient, leading to 0.09 QALY with a cost-effectiveness ratio of 477 pounds sterling/QALY. CONCLUSION: Implanting the costlier device increases the cost of the initial operation; however, this is expected to be offset by a reduction in costs associated with re-operations and AF. 相似文献
29.
Cytogenetic and molecular analysis in Philadelphia negative CML 总被引:2,自引:0,他引:2
van der Plas DC; Hermans AB; Soekarman D; Smit EM; de Klein A; Smadja N; Alimena G; Goudsmit R; Grosveld G; Hagemeijer A 《Blood》1989,73(4):1038-1044
30.