全文获取类型
收费全文 | 2823篇 |
免费 | 173篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 88篇 |
妇产科学 | 64篇 |
基础医学 | 261篇 |
口腔科学 | 54篇 |
临床医学 | 280篇 |
内科学 | 587篇 |
皮肤病学 | 44篇 |
神经病学 | 129篇 |
特种医学 | 99篇 |
外科学 | 476篇 |
综合类 | 47篇 |
一般理论 | 7篇 |
预防医学 | 302篇 |
眼科学 | 104篇 |
药学 | 289篇 |
中国医学 | 26篇 |
肿瘤学 | 126篇 |
出版年
2024年 | 8篇 |
2023年 | 32篇 |
2022年 | 104篇 |
2021年 | 112篇 |
2020年 | 83篇 |
2019年 | 122篇 |
2018年 | 139篇 |
2017年 | 103篇 |
2016年 | 112篇 |
2015年 | 110篇 |
2014年 | 143篇 |
2013年 | 205篇 |
2012年 | 252篇 |
2011年 | 266篇 |
2010年 | 140篇 |
2009年 | 128篇 |
2008年 | 177篇 |
2007年 | 155篇 |
2006年 | 143篇 |
2005年 | 115篇 |
2004年 | 90篇 |
2003年 | 81篇 |
2002年 | 55篇 |
2001年 | 21篇 |
2000年 | 12篇 |
1999年 | 9篇 |
1998年 | 12篇 |
1997年 | 12篇 |
1996年 | 9篇 |
1995年 | 6篇 |
1994年 | 6篇 |
1993年 | 2篇 |
1992年 | 7篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 5篇 |
1987年 | 5篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1975年 | 5篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1968年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有3014条查询结果,搜索用时 15 毫秒
41.
Nima Hafezi-Nejad Mohsen Khosravi Nooshin Bayat Ariana Kariminejad Valeh Hadavi Christian Oberkanins 《Hemoglobin》2014,38(3):153-157
Our study aimed to determine the number of couples with normal hemoglobin (Hb) electrophoresis and low-borderline hematological values, which may come up with a clinically critical status in their offspring. The number of couples at risk for severe α-thalassemia (α-thal) needed to be estimated before recommending genetic counseling and prenatal diagnosis (PND). During the past 14 years, from at least 7000 referrals, 754 couples were investigated for α-thal by direct mutation detection methods followed by reverse strip assay and α-globin gene sequencing for inconclusive cases. Detection of silent β-thalassemia (β-thal) mutations was done in suspected cases by complete β-globin gene sequencing. We were able to provide a molecular diagnosis in 87.3% (658/754) of couples. A total of 9.1% (60/658) may have a clinically significant hemoglobinopathy in their offspring. Significant conditions included hydrops fetalis (20.0%; 12/60), certain Hb H (β4) genotypes (78.3%; 47/60) and β-thal intermedia (β-TI) (1.7%; 1/60). The diagnostic flowchart for couples with microcytic hypochromic anemia in countries with a high prevalence of hemoglobinopathies should include α and β gene sequencing. As our results indicate, every nine out of 100 of these couples will face significant hemoglobinopathies and every two out of 100 can carry Hb Bart’s (γ4) hydrops fetalis in their pregnancies. For such cases, PND should be utilized to allow the carrier couples to decide whether or not to abort the fetus. 相似文献
42.
43.
Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience researches and therapies. Taking advantage of the nanoscale structure of neural cells (both neurons and glia); nanodrug delivery (second generation of biotechnological products) has a potential revolutionary impact into the basic understanding, visualization and therapeutic applications of neuroscience. Current review article firstly provides an overview of preparation and characterization, purification and separation, loading and delivering of nanodrugs. Different types of nanoparticle bioproducts and a number of methods for their fabrication and delivery systems including (carbon) nanotubes are explained. In the second part, neuroscience and nervous system drugs are deeply investigated. Different mechanisms in which nanoparticles enhance the uptake and clearance of molecules form cerebrospinal fluid (CSF) are discussed. The focus is on nanodrugs that are being used or have potential to improve neural researches, diagnosis and therapy of neurodegenerative disorders. 相似文献
44.
45.
46.
47.
48.
Mehdi Esfandyari-Manesh Seyed Hossein Mostafavi Reza Faridi Majidi Mona Noori Koopaei Nazanin Shabani Ravari Mohsen Amini Behrad Darvishi Seyed Nasser Ostad Fatemeh Atyabi Rassoul Dinarvand 《Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences》2015,23(1)
Background
Nanoparticles (NPs) play an important role in anticancer delivery systems. Surface modified NPs with hydrophilic polymers such as human serum albumin (HSA) have long half-life in the blood circulation system.Methods
The method of modified nanoprecipitation was utilized for encapsulation of paclitaxel (PTX) in poly (lactic-co-glycolic acid) (PLGA). Para-maleimide benzoic hydrazide was conjugated to PLGA for the surface modifications of PLGA NPs, and then HSA was attached on the surface of prepared NPs by maleimide attachment to thiol groups (cysteines) of albumin. The application of HSA provides for the longer blood circulation of stealth NPs due to their escape from reticuloendothelial system (RES). Then the physicochemical properties of NPs like surface morphology, size, zeta potential, and in-vitro drug release were analyzed.Results
The particle size of NPs ranged from 170 to 190 nm and increased about 20–30 nm after HSA conjugation. The zeta potential was about -6 mV and it decreased further after HSA conjugation. The HSA conjugation in prepared NPs was proved by Fourier transform infrared (FT-IR) spectroscopy, faster degradation of HSA in Differential scanning calorimetry (DSC) characterization, and other evidences such as the increasing in size and the decreasing in zeta potential. The PTX released in a biphasic mode for all colloidal suspensions. A sustained release profile for approximately 33 days was detected after a burst effect of the loaded drug. The in vitro cytotoxicity evaluation also indicated that the HSA NPs are more cytotoxic than plain NPs.Conclusions
HSA decoration of PLGA NPs may be a suitable method for longer blood circulation of NPs. 相似文献49.
Mohsen Mosleh Cameron Martel Dean Eckles David G. Rand 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(7)
Americans are much more likely to be socially connected to copartisans, both in daily life and on social media. However, this observation does not necessarily mean that shared partisanship per se drives social tie formation, because partisanship is confounded with many other factors. Here, we test the causal effect of shared partisanship on the formation of social ties in a field experiment on Twitter. We created bot accounts that self-identified as people who favored the Democratic or Republican party and that varied in the strength of that identification. We then randomly assigned 842 Twitter users to be followed by one of our accounts. Users were roughly three times more likely to reciprocally follow-back bots whose partisanship matched their own, and this was true regardless of the bot’s strength of identification. Interestingly, there was no partisan asymmetry in this preferential follow-back behavior: Democrats and Republicans alike were much more likely to reciprocate follows from copartisans. These results demonstrate a strong causal effect of shared partisanship on the formation of social ties in an ecologically valid field setting and have important implications for political psychology, social media, and the politically polarized state of the American public. 相似文献
50.
Liver transplantation as a definitive treatment for familial hypercholesterolemia: A series of 36 cases
下载免费PDF全文
![点击此处可从《Pediatric transplantation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mohsenreza Mansoorian Kourosh Kazemi Saman Nikeghbalian Alireza Shamsaeefar Maral Mokhtari Seyed Mohsen Dehghani Ali Bahador Heshmatollah Salahi Hamid Amoozgar Seyed Ali Malek Hosseini 《Pediatric transplantation》2015,19(6):605-611
FH is a genetic disorder characterized by an increase in serum LDL and total cholesterol values. The afflicted patients are at increased risk of premature atherosclerosis and myocardial infarction. Different treatment modalities are present, including pharmacological agents and surgical procedures. The most effective method of therapy in refractive cases is liver transplantation. Herein, we report our experience on 36 cases of patients with FH undergoing liver transplantation in our center, the main referral center of liver transplantation in Iran. The clinical findings, hospital courses, post‐operative complications, and patient follow‐up are also described. 相似文献