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991.
Al-Refaey Kandeel Usama Abdalla Mohamed Abouelella Mohammed Elmorshedi Waleed Elsarraf Mohammed Abdelwahab Amr Yassen 《Egyptian Journal of Anaesthesia》2018,34(2):55-59
Introduction
Living donor liver transplantation (LDLT) is a complex surgery with high risk for massive bleeding and blood component transfusion. This retrospective study investigated the effect of adopting ROTEM based transfusion algorithm on blood products transfusion practice among LDLT recipients and the effect of this change on patient outcome.Material and methods
Data of 216 patients with predicted intraoperative massive bleeding (blood loss ≥70?ml blood/kg, or blood loss >150?ml/min with hemodynamic affection with continuing need for transfusion) were collected from our database. Patients were divided into two groups according to transfusion protocol applied; Pre-ROTEM group (n?=?95), ROTEM group (n?=?121). Basal characteristics, blood component transfusion, graft outcome and patient outcome (28-day mortality and one-year mortality) were compared between the two groups.Results
Transfused packed red blood cells (PRBCs) units, fresh frozen plasma (FFP) units, and application of massive transfusion protocol (MTP) were significantly lower in the ROTEM group compared to pre-ROTEM group [8(7) vs 4.5(5), p?<?0.01, 12.5(4) vs 5.6(3), p?<?0.001, 29% vs 20%, p?<?0.005 respectively]. The survival distributions for the two studied groups showed no statistically significant difference, p?<?0.46.Conclusions
ROTEM based transfusion algorithms applied in LDLT decreased blood component transfusion and enhanced early graft function. 相似文献992.
Sameh Abdelkhalik Ahmed Mohamad Gamal Elmawy Mohammed Awd 《Egyptian Journal of Anaesthesia》2018,34(1):21-25
Background
The use of an adjuvant to local anesthetics in the peribulbar block may improve the block characteristics. This study aimed to evaluate the effect of the addition of either ketamine or fentanyl to local anesthetics in single injection peribulbar block on the quality of the block.Methods
The study included ninety adult patients presented for vitreoretinal surgeries. Patients were randomly allocated into three groups. All patients received peribulbar block with a local anesthetic mixture composed of 4?ml lidocaine 2% containing hyaluronidase, and 5?ml of plain bupivacaine 0.5% with an addition of either 1?ml of normal saline, 30?μg fentanyl, or 25?mg ketamine in Control group, Fentanyl group, and Ketamine group respectively. The measurements included the onset and duration of both anesthesia and akinesia with evaluation of intraocular pressure, postoperative pain score and need of analgesics.Results
As compared to control group, the use of either fentanyl or ketamine as local anesthetic adjuvant significantly fastened the onset of anesthesia (1.67?±?1.21?min) (1.93?±?1.36?min), prolonged the duration of lid akinesia (127.50?±?22.20?min) (127.00?±?22.19?min), increased the duration of globe akinesia (156.00?±?28.02?min) (158.00?±?31.18?min), minimized the time required to start surgery (6.57?±?1.99?min) (6.57?±?1.85?min), and increased the time for first request of postoperative analgesia (189.50?±?34.92?min) (184.67?±?35.37?min) (P?<?.05). However, neither fentanyl nor ketamine had a significant effect on the onset of lid or globe akinesia or the intraocular pressure (P?>?.05).Conclusion
Fentanyl or ketamine can be used as a local anesthetic adjuvant in the peribulbar block in patients presented for vitreoretinal surgeries as both of them improved the quality of the block without increasing intraocular pressure. 相似文献993.
Karkouti K Wijeysundera DN Yau TM Beattie WS Abdelnaem E McCluskey SA Ghannam M Yeo E Djaiani G Karski J 《Transfusion》2004,44(10):1453-1462
BACKGROUND: Although the association between massive perioperative blood loss (MBL) and adverse outcomes is well recognized, it is unclear whether MBL is an independent risk factor or, instead, simply a marker for other adverse events or severity of illness. The objective of this cohort study was to quantify the independent association of MBL in cardiac surgery with all-cause in-hospital mortality. STUDY DESIGN AND METHODS: Data were prospectively collected on consecutive patients who underwent cardiac surgery with cardiopulmonary bypass at a quaternary-care academic center from 1999 to 2003. The number of red blood cell (RBC) units transfused within 1 day of surgery was used as a surrogate measure of perioperative blood loss. Receiver-operating characteristic curve analyses were employed to identify the most appropriate cutoff for defining MBL. The independent association of MBL with mortality was determined with multivariable logistic regression analyses. Bootstrapping and sensitivity analyses were used to confirm the validity of the results. RESULTS: MBL was defined as receiving at least 5 units of RBCs within 1 day of surgery. Of 9215 patients analyzed, 1.8 percent (n = 169) died and 9.7 percent (n = 890) had MBL. After adjusting for multiple potential confounders (including perioperative adverse events), MBL was associated with an 8.1-fold (95% confidence interval, 3.9-17.0) increase in the odds of death. This risk estimate was stable across different modeling conditions as well as in bootstrap sampling. CONCLUSION: MBL after cardiac surgery has a strong, independent association with in-hospital mortality. 相似文献
994.
995.
Hamamoto S Fukuda R Ishimura N Rumi MA Kazumori H Uchida Y Kadowaki Y Ishihara S Kinoshita Y 《The Journal of laboratory and clinical medicine》2003,141(1):58-66
The concentration of type I interferon receptor (IFN-Rc) in the liver is a crucial factor in determining the efficacy of interferon (IFN) therapy in patients with chronic hepatitis C. Retinoic acids (RAs) can enhance the expression of type I IFN-Rc expression. The aim of this study was to investigate whether RAs increase the anti-hepatitis C virus (HCV) effect of IFN through an increase in IFN-Rc. The hepatocellular carcinoma cell line HuH-7 was treated with 10(-7) mol/L all-trans RA (ATRA) and 9-cis RA (9-CRA). Expression of type I IFN-Rc was investigated at both the mRNA and protein levels with the use of real-time quantitative polymerase chain reaction and flow cytometry, respectively. We investigated the anti-HCV effect, using in vitro HCV transfection, by monitoring the level of HCV RNA in the culture medium. ATRA and 9-CRA enhanced the expression of type I IFN-Rc at both the mRNA and protein levels. After IFN-alpha treatment, the activity of 2,5'-oligoadenylate synthetase was enhanced by RAs, and this enhancement was abolished when blocking antibodies had previously been bound to the surface receptors. IFN treatment decreased the concentration of HCV RNA, and this effect was enhanced by treatment with RAs. Our findings suggest that RAs enhance the anti-HCV replication effect of IFN-alpha through up-regulation of type I IFN-Rc in HuH-7 cells. 相似文献
996.
Eli Carmeli Iris Orbach Tzvia Zinger‐Vaknin Mohammed Morad Joav Merrick 《Journal of Applied Research in Intellectual Disabilities》2008,21(5):457-465
Background Exercise is important for health and well‐being. The aim of this study was to investigate the effect of physical training on general well‐being and self‐image in older people with intellectual disability. Methods This study evaluated older adults with intellectual disability in residential care in Israel. The concept of well‐being perceived by the participants was measured by direct interview with a questionnaire consisting of 37 structural statements. The physical training programme was conducted three times a week for 10 consecutive months. Results Statistical analyses suggested a positive relationship between perceived well‐being and physical training between the experimental and control group. Conclusions This positive relation supports the important role of physical training to improve perceived well‐being among older adults with intellectual disability. 相似文献
997.
998.
Tianli Du Katherine A. Bill Jennifer Ford Mohammed Barawi Richard D. Hayward Amer Alame Richard N. Berri 《American journal of surgery》2018,215(3):472-475
Background
Pancreatic cancer is the fourth leading cause of cancer-related death in United States. We compared Computed Tomography (CT) with pancreas protocol and Endoscopic Ultrasound (EUS) in terms of mass detection, mass size, vascular involvement and lymph node involvement.Methods
We retrospectively evaluated 93 patients. Concordance between CT and EUS, and accuracy of CT and EUS were assessed using a retrospective chart review and statistical analysis.Results
CT and EUS agreed on mass detection in 88% of the cases and mass size in 67% of the cases. They agreed in 74% of cases about the presence or absence of vascular involvement and 82% in lymph node involvement. Cohen's kappa indicated that the concordance between two tests was moderately reliable.Conclusion
CT and EUS agree moderately well in identifying characteristics of pancreatic masses, but discrepancies between the two modalities are common, particularly with respect to involvement of specific blood vessels and lymph nodes. Clinicians should use caution in relying on a single modality to make decisions. 相似文献999.
Amro Mohamed Sedky El-Ghammaz Hoda Ahmed Gadallah Gihan Kamal Mohammed Magdy Maher Mohamad Ayed Mohamad 《Clinical and experimental medicine》2018,18(4):505-512
Programmed death ligand-1 (PD-L1) plays an important role in the immune evasion of cancer cells and, in turn, can influence the outcome of many malignancies. The serum soluble PD-L1 (sPD-L1) levels were measured in diffuse large B cell lymphoma (DLBCL) patients at diagnosis and at end of treatment. Their impact on end of treatment metabolic response was analyzed. Serum sPD-L1 level was significantly elevated in DLBCL patients at diagnosis than in controls (P?<?0.001). Also, serum sPD-L1 level at diagnosis was significantly higher than that at end of treatment (P?<?0.001). Patients who achieved partial response (PR) had significantly higher serum sPD-L1 level at end of treatment than controls (P?<?0.001). In contrast, all patients especially those who achieved complete response (CR) had insignificantly different serum sPD-L1 level at end of treatment than controls (P?=?0.354 and P?=?0.090, respectively). There was a significant difference between serum sPD-L1 level at diagnosis and that at end of treatment in patients who achieved PR and CR (P?=?0.023 and P?<?0.001, respectively). On univariate analysis, presence of comorbidities, Ann Arbor stage IV, high serum sPD-L1 level at diagnosis and high serum sPD-L1 level at end of treatment were significantly associated with achievement of PR (P?=?0.018 and P?=?0.043, P?=?0.045 and P?<?0.001, respectively). On multivariate analysis, serum sPD-L1 levels at diagnosis and at end of treatment were still influencing metabolic response significantly (P?=?0.014 and P?=?0.007, respectively). Serum sPD-L1 is a predictor for metabolic response to immunochemotherapy in DLBCL patients. 相似文献
1000.
Genotypic and phenotypic resistance patterns of human immunodeficiency virus type 1 variants with insertions or deletions in the reverse transcriptase (RT): multicenter study of patients treated with RT inhibitors 下载免费PDF全文