全文获取类型
收费全文 | 18994篇 |
免费 | 1115篇 |
国内免费 | 145篇 |
专业分类
耳鼻咽喉 | 220篇 |
儿科学 | 502篇 |
妇产科学 | 664篇 |
基础医学 | 2070篇 |
口腔科学 | 530篇 |
临床医学 | 1566篇 |
内科学 | 3799篇 |
皮肤病学 | 379篇 |
神经病学 | 886篇 |
特种医学 | 724篇 |
外国民族医学 | 11篇 |
外科学 | 3351篇 |
综合类 | 340篇 |
现状与发展 | 2篇 |
一般理论 | 11篇 |
预防医学 | 1636篇 |
眼科学 | 545篇 |
药学 | 1751篇 |
中国医学 | 138篇 |
肿瘤学 | 1129篇 |
出版年
2024年 | 17篇 |
2023年 | 249篇 |
2022年 | 771篇 |
2021年 | 1118篇 |
2020年 | 608篇 |
2019年 | 759篇 |
2018年 | 1022篇 |
2017年 | 599篇 |
2016年 | 627篇 |
2015年 | 636篇 |
2014年 | 898篇 |
2013年 | 1038篇 |
2012年 | 1514篇 |
2011年 | 1659篇 |
2010年 | 943篇 |
2009年 | 679篇 |
2008年 | 956篇 |
2007年 | 965篇 |
2006年 | 883篇 |
2005年 | 851篇 |
2004年 | 733篇 |
2003年 | 680篇 |
2002年 | 604篇 |
2001年 | 142篇 |
2000年 | 111篇 |
1999年 | 98篇 |
1998年 | 76篇 |
1997年 | 73篇 |
1996年 | 72篇 |
1995年 | 64篇 |
1994年 | 59篇 |
1993年 | 50篇 |
1992年 | 47篇 |
1991年 | 55篇 |
1990年 | 54篇 |
1989年 | 46篇 |
1988年 | 49篇 |
1987年 | 46篇 |
1986年 | 38篇 |
1985年 | 38篇 |
1984年 | 39篇 |
1983年 | 36篇 |
1982年 | 33篇 |
1981年 | 23篇 |
1980年 | 21篇 |
1978年 | 16篇 |
1977年 | 14篇 |
1976年 | 17篇 |
1974年 | 13篇 |
1973年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
Christoph A. Nienaber Natzi Sakalihasan Rachel E. Clough Mohamed Aboukoura Enrico Mancuso James S.M. Yeh Jean-Olivier Defraigne Nick Cheshire Ulrich Peter Rosendahl Cesare Quarto John Pepper 《The Journal of thoracic and cardiovascular surgery》2017,153(2):S3-S11
Objective
Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role in managing proximal aortic pathologies is unknown—this is important because in proximal (Stanford type A) aortic dissections, 10% to 30% are not accepted for surgery and 30% to 50% are technically amenable for TEVAR. We describe our case series of type A aortic dissections treated by using TEVAR.Methods
Between year 2009 and 2016, 12 patients with acute, subacute, or chronic type A aortic dissection with the proximal entry tear located between the coronaries and brachiocephalic artery were treated with TEVAR at 3 centers. Various stent-graft configurations were used to seal the proximal entry tear in the ascending aorta under rapid pacing.Results
A total of 12 patients (9 male, 3 female), mean age 81 ± 7 years, EuroSCORE II 9.1 ± 4.5, underwent TEVAR for the treatment of type A aortic dissection. Procedural success was achieved in 11 of 12 patients (91.7%). There was 1 minor stroke and 1 intraprocedural death. No additional deaths were reported at 30 days. At 36 months, there were 4 further deaths (all from nonaortic causes). The mean survival of these 4 deceased was 23 months (range 15-36 months). Follow-up computed tomography demonstrated favorable aortic remodeling.Conclusions
TEVAR is feasible and reveals promising early results in selected patients with type A aortic dissection who are poor candidates for surgical repair. The current iteration of stent-graft technology, however, needs to be adapted to features specific to the ascending aorta. 相似文献993.
Prenatal Stress Increases the Hypothalamo-Pituitary-Adrenal Axis Response in Young and Adult Rats 总被引:11,自引:0,他引:11
Chantal Henry Mohamed Kabbaj Hervé Simon Michel Le Moal Stefania Maccari 《Journal of neuroendocrinology》1994,6(3):341-345
Prenatal stress is considered as an early epigenetic factor able to induce long-lasting alterations in brain structures and functions. It is still unclear whether prenatal stress can induce long-lasting modifications in the hypothalamo-pituitary-adrenal axis. To test this possibility the effects of restraint stress in pregnant rats during the third week of gestation were investigated in the functional properties of the hypothalamo-pituitary-adrenal axis and hippocampal type I and type II corticosteroid receptors in the male offspring at 3, 21 and 90 days of age. Plasma corticosterone was significantly elevated in prenatally-stressed rats at 3 and 21 days after exposure to novelty. At 90 days of age, prenatally-stressed rats showed a longer duration of corticosterone secretion after exposure to novelty. No change was observed for type I and type II receptor densities 3 days after birth, but both receptor subtypes were decreased in the hippocampus of prenatally-stressed offspring at 21 and 90 days of life. These findings suggest that prenatal stress produces long term changes in the hypothalamo-pituitary-adrenal axis in the offspring. 相似文献
994.
995.
996.
997.
998.
ABSTRACT: The European Network for Breast Development and Cancer (ENBDC) meeting on 'Methods in Mammary Gland Development and Cancer' has become an annual international rendezvous for scientists with interests in the normal and neoplastic breast. The fourth meeting in this series, held in April in Weggis, Switzerland, focused on proteomics, epigenetics, symmetric division, and metastasis. 相似文献
999.
1000.