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排序方式: 共有3713条查询结果,搜索用时 15 毫秒
91.
Masatsugu Ohara Goki Suda Megumi Kimura Osamu Maehara Tomoe Shimazaki Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Tomoe Kobayashi Minoru Uebayashi Ryo Takagi Isao Yokota Tsuyoshi Shimamura Naoya Sakamoto 《Hepatology research》2020,50(6):715-725
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An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression
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Mio Yano Toshihiko Imamura Daisuke Asai Akiko Moriya‐Saito So‐ichi Suenobu Daiichiro Hasegawa Takao Deguchi Yoshiko Hashii Hirohide Kawasaki Hiroki Hori Yoshiyuki Kosaka Koji Kato Keizo Horibe Keiko Yumura‐Yagi Junichi Hara Kenji Matsumoto Nobutaka Kiyokawa Megumi Oda Atsushi Sato for the Japan Association of Childhood Leukemia Study 《Genes, chromosomes & cancer》2014,53(10):815-823
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Ohta Shin Tanaka Akihiko Jinno Megumi Hirai Kuniaki Miyata Yoshito Yamaguchi Munehiro Homma Tetsuya Muramoto Mayumi Watanabe Yoshio Suzuki Shintaro Yokoe Takuya Sagara Hironori 《Sleep & breathing》2020,24(2):523-532
Sleep and Breathing - Obesity increases the severity of asthma, and patients with severe asthma are often complicated with obstructive sleep apnea syndrome (OSAS), a concomitant disease of obesity.... 相似文献
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The study investigated age-related changes in the thickness of the deep and superficial abdominal muscles of 103 healthy women who could walk independently The participants were classified into five age groups: young (n=26; 20-24 years), young adult (n=26; 25-44 years), middle-aged (n=16; 45-64 years), young-old (n=16; 65-74 years), and old-old (n=19; 75-85 years). The muscle thicknesses of the right rectus abdominis, external oblique, internal oblique, and transversus abdominis were measured using ultrasound imaging. The rectus abdominis was significantly thicker in the young group compared with the young adult, middle-aged, young-old, and old-old groups (p<0.05). The external oblique and internal oblique muscles were significantly thicker in the young group compared with the middle-aged, young-old, and old-old groups (p<0.05). However, there were no significant differences in the thickness of the transversus abdominis between groups. The results suggest that age-related muscle atrophy occurs from an early age in superficial abdominal muscles, such as rectus abdominis, and that age-related atrophy is less in deep abdominal muscles such as the transversus abdominis. 相似文献
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Leung DT Bogetz J Itoh M Ganapathi L Pietroni MA Ryan ET Chisti MJ 《The American journal of tropical medicine and hygiene》2012,86(4):698-702
To characterize clinical correlates of typhoid fever-associated encephalopathy, we performed a retrospective chart review of patients with Salmonella enterica serotype Typhi bacteremia who were hospitalized at the International Centre for Diarrhoeal Disease Research, Bangladesh, from February of 2009 to June of 2011. Of 207 patients bacteremic with Salmonella Typhi who were ≥ 5 years of age, we identified 43 (21%) patients with encephalopathy. Univariate analysis revealed that patients with encephalopathy more often presented at ages of 10-24 years and had severe dehydration, low oxygen saturation, high respiratory rate, low leukocyte count, low platelet count, and Widal flagellar H agglutinin (TH) titer ≥ 1:640 compared with typhoid patients without encephalopathy. Multivariate analysis using logistic regression showed that age, dehydration, leukocyte count, and Widal TH titer were independently associated with encephalopathy. Our findings suggest that age, severity of disease, and immune responses are associated with encephalopathy during Salmonella Typhi bacteremia, perhaps reflecting the impact of prominent inflammatory responses. 相似文献
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I Bendit SS Sanabani M Conchon M Serpa MM Novaes L Nardinelli TD Pereira L Tucunduva PD Ferreira PE Dorlhiac-Llacer DD Fischer Chamone 《Acta haematologica》2012,128(4):223-232
Here we compare the management and survival outcomes of chronic myeloid leukemia (CML) patients who had early or late imatinib mesylate (IM) therapy. The cytogenetic and molecular responses of 189 CML patients were analyzed. Of this group, 121 patients were classified as the early chronic phase (ECP) group and started IM within 12 months of diagnosis. The other 68 patients were classified as the late chronic phase (LCP) group who had been treated with interferon (IFN)-alpha-2 and crossed over to IM more than 12 months after diagnosis. The overall rates of complete cytogenetic response (CCyR) and major molecular response (MMR) at last follow-up were 83.6 and 78.1% in the ECP and LCP groups, respectively. The CCyR rates were 89.3 (for ECP patients) versus 73.5% (for LCP patients; p < 0.0001). At last follow-up, 82.4% ECP and 64.2% LCP patients had achieved an MMR (p < 0.0001). No significant differences were noted between the two groups with regard to survival outcomes. Our experience reveals that IM is an effective rescue therapy in most CML LCP patients who are intolerant or in whom IFN-alpha therapy fails. Such therapeutic options should be considered in LCP patients, particularly in countries where IM may not be available. 相似文献