全文获取类型
收费全文 | 3719篇 |
免费 | 188篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 71篇 |
妇产科学 | 38篇 |
基础医学 | 532篇 |
口腔科学 | 62篇 |
临床医学 | 197篇 |
内科学 | 827篇 |
皮肤病学 | 79篇 |
神经病学 | 225篇 |
特种医学 | 147篇 |
外科学 | 701篇 |
综合类 | 14篇 |
预防医学 | 162篇 |
眼科学 | 20篇 |
药学 | 186篇 |
中国医学 | 6篇 |
肿瘤学 | 642篇 |
出版年
2023年 | 19篇 |
2022年 | 31篇 |
2021年 | 69篇 |
2020年 | 43篇 |
2019年 | 64篇 |
2018年 | 51篇 |
2017年 | 41篇 |
2016年 | 78篇 |
2015年 | 77篇 |
2014年 | 99篇 |
2013年 | 105篇 |
2012年 | 170篇 |
2011年 | 215篇 |
2010年 | 105篇 |
2009年 | 86篇 |
2008年 | 161篇 |
2007年 | 182篇 |
2006年 | 179篇 |
2005年 | 194篇 |
2004年 | 180篇 |
2003年 | 179篇 |
2002年 | 156篇 |
2001年 | 147篇 |
2000年 | 131篇 |
1999年 | 146篇 |
1998年 | 67篇 |
1997年 | 47篇 |
1996年 | 45篇 |
1995年 | 34篇 |
1994年 | 35篇 |
1993年 | 35篇 |
1992年 | 82篇 |
1991年 | 94篇 |
1990年 | 91篇 |
1989年 | 61篇 |
1988年 | 66篇 |
1987年 | 68篇 |
1986年 | 50篇 |
1985年 | 50篇 |
1984年 | 38篇 |
1983年 | 21篇 |
1982年 | 18篇 |
1979年 | 19篇 |
1977年 | 9篇 |
1973年 | 6篇 |
1972年 | 10篇 |
1971年 | 7篇 |
1970年 | 7篇 |
1969年 | 10篇 |
1968年 | 8篇 |
排序方式: 共有3924条查询结果,搜索用时 10 毫秒
51.
Erin J Aiello Shelley S Tworoger Yutaka Yasui Frank Z Stanczyk John Potter Cornelia M Ulrich Melinda Irwin Anne McTiernan 《Cancer epidemiology, biomarkers & prevention》2005,14(6):1411-1417
OBJECTIVE: Hormone therapy use has been positively associated with mammographic density in several studies. However, few studies have examined the association between endogenous hormone levels and mammographic density. Therefore, we evaluated the relationship of endogenous sex hormones, insulin-like growth factor (IGF), and lipids with mammographic density in 88 overweight, postmenopausal women not taking hormone therapy. METHODS: Percent density and dense area were evaluated as continuous measures using a computer-assisted program. We used multiple linear regression to evaluate the associations of sex hormones, IGF, and cholesterol with mammographic density, adjusting for confounders, including adiposity. We evaluated stratification by history of hormone therapy use (former versus never) and hormone therapy latency (<5 versus > or = 5 years). RESULTS: Among former hormone therapy users, mammographic density was inversely associated with circulating levels of estrone (P = 0.01), estradiol (P = 0.003), free estradiol (P = 0.004), testosterone (P = 0.04), free testosterone (P = 0.02), androstenedione (P < 0.001), dehydroepiandrosterone (P = 0.01), and the ratio of IGF-I to its binding protein (IGF-I/IGFBP-3; P = 0.04). We found similar associations when we limited the analyses to women who had used hormone therapy within the past 5 years. We also noted positive associations of mammographic density with total cholesterol (P = 0.03) and low-density lipoprotein (P = 0.03) among former hormone therapy users. No associations were noted among women who had never used hormone therapy. CONCLUSIONS: These results suggest that there is an inverse relationship between endogenous sex hormones and mammographic density in postmenopausal women among former users of hormone therapy. This is not consistent with the hormone therapy literature and should be confirmed in larger studies. 相似文献
52.
53.
PURPOSE: To compare higher order wavefront aberrations in eyes implanted with acrylic aspherical intraocular lenses (IOLs) with a modified prolate anterior surface with conventional acrylic spherical IOLs by using the optical path difference method. METHODS: In a nonrandomized parallel cohort investigation, 36 eyes of 31 patients implanted with aspherical IOLs (Tecnis ZA9003) and 37 eyes of 23 age-matched patients implanted with spherical IOLs (SENSOR AR40e) were evaluated with a wavefront analyzer (OPD-Scan II) preoperatively and 1 month after surgery. The higher order aberrations for a 4.0-mm pupil diameter were expanded into Zernike's polynomial expression. Coma aberration, spherical aberration, and total higher order aberrations were evaluated as root mean square values. RESULTS: Postoperatively, coma and total higher order aberrations of spherical and aspherical IOLs significantly improved in both eyes. Spherical aberration improved in eyes with aspherical IOLs only (P < 0.01). CONCLUSION: After implantation of acrylic aspherical IOLs, postoperative higher order aberrations were not necessarily lower than after implantation of acrylic spherical IOLs, but compared with levels following implantation of acrylic spherical IOLs, a significant reduction in spherical aberration was achieved. 相似文献
54.
Ryota Imai Masakazu Imaoka Hidetoshi Nakao Mitsumasa Hida Fumie Tazaki Takao Inoue Junya Orui Misa Nakamura 《Medicine》2022,101(32)
Older people with chronic pain are at higher risk of developing sarcopenia. Central sensitization (CS) has been implicated in chronic pain among community-dwelling older adults. However, a relationship between CS and chronic pain with sarcopenia has not been established. This cross-sectional study aimed to clarify the relationship between chronic pain with sarcopenia or presarcopenia and CS among community-dwelling older adults. We assessed chronic pain and sarcopenia in 104 older adults participating in community health checks. We defined sarcopenia using the Asian Working Group for Sarcopenia (AWGS) consensus recommendations based on the following outcomes: low muscle mass, low muscle strength, and slow gait speed. Pain-related assessments included pain intensity, the Pain Catastrophizing Scale, the CS Inventory-9, the pressure pain threshold, the Tampa Scale of Kinesiophobia-11, and the EuroQol 5-dimension 5-level (EQ5D-5L). Chronic pain was defined by related symptoms within the month prior to the health check that had continued for ≥ 3 months and corresponded to a numerical rating scale score of ≥ 1 at the site of maximum pain. The prevalence of chronic pain was 43.3%. In addition, the prevalence of chronic pain with sarcopenia or presarcopenia was 29.8%. A logistic regression analysis revealed that the pressure pain threshold (odds ratio: 0.82, 95% CI: 0.95–1.02) and the EQ5D-5L (odds ratio: 0.58, 95% CI: 0.36–0.76) were significantly associated with the presence of chronic pain with sarcopenia or presarcopenia. Chronic pain with sarcopenia or presarcopenia was affected by central sensitization. Therefore, CS should be evaluated in the elderly. 相似文献
55.
Kensei Yamaguchi Keiko Minashi Daisuke Sakai Tomohiro Nishina Yasushi Omuro Masahiro Tsuda Shiroh Iwagami Hisato Kawakami Taito Esaki Naotoshi Sugimoto Takashi Oshima Ken Kato Kenji Amagai Hisashi Hosaka Keigo Komine Hisateru Yasui Yuji Negoro Kenji Ishido Takahiro Tsushima Shirong Han Shinichi Shiratori Tomoko Takami Kohei Shitara 《Cancer science》2022,113(8):2814
The KEYNOTE‐659 study evaluated the efficacy and safety of first‐line pembrolizumab plus S‐1 and oxaliplatin (SOX) (cohort 1) or S‐1 and cisplatin (SP) (cohort 2) for advanced gastric/gastroesophageal junction (G/GEJ) cancer in Japan. Herein, we update the results of cohort 1 and describe the results of cohort 2. This open‐label phase IIb study enrolled patients with advanced programmed death‐ligand 1 (PD‐L1)‐positive (combined positive score ≥ 1) human epidermal growth factor receptor 2 (HER2)‐negative G/GEJ adenocarcinoma. The primary end‐point was the objective response rate (ORR). Other end‐points were duration of response (DOR), disease control rate (DCR), progression‐free survival (PFS), overall survival (OS), and safety. One hundred patients were enrolled. In cohorts 1 and 2, median follow‐up time was 16.9 and 17.1 months; ORR (central review), 72.2% and 80.4%; DOR, 10.6 and 9.5 months; DCR (central review), 96.3% and 97.8%; median PFS (central review), 9.4 and 8.3 months; and median OS, 16.9 and 17.1 months, respectively. Treatment‐related adverse events (TRAEs) occurred in all patients, including peripheral sensory neuropathy (94.4%, cohort 1), decreased neutrophil count (82.6%, cohort 2), nausea (59.3% and 60.9% in cohorts 1 and 2), and decreased appetite (61.1% and 60.9% in cohorts 1 and 2). Grade 3 or higher TRAEs were reported by 59.3% (cohort 1) and 78.3% (cohort 2), including decreased platelet count (14.8%, cohort 1) and decreased neutrophil count (52.2%, cohort 2). Pembrolizumab in combination with SOX or SP showed favorable efficacy and safety in patients with PD‐L1‐positive, HER2‐negative G/GEJ adenocarcinoma. 相似文献
56.
An eight-year-old girl (second-year of elementary school) was strangled in an irrigation canal near her house and was left unconscious. The body of a male who hanged himself to death was discovered on the next day. The hanging mark on the neck of the man and the ligature mark on the neck of the girl were caused by double nooses of a rope, the width of the rope mark was nearly the same, and similar Zwischenkammblutung (subcutaneous bleeding in the middle of the rope mark) was observed in both cases. Therefore, we evaluated whether the marks were caused by the same rope. As a result, the DNA type of the skin fragment (keratinized epithelial cells) attached to the rope used by the man to hang himself was identical to that of the girl. On the basis of this evidence, the man who hanged himself to death was presumed to be the suspect who strangled the girl. 相似文献
57.
Value of percutaneous transhepatic cholangioscopy (PTCS) 总被引:4,自引:0,他引:4
Yuji Nimura Shigehiko Shionoya Naokazu Hayakawa Junichi Kamiya Satoshi Kondo Akihiro Yasui 《Surgical endoscopy》1988,2(4):213-219
Since July 1975, percutaneous transhepatic biliary drainage (PTBD) has been performed in 533 cases, and since April 1977 we have developed percutaneous transhepatic cholangioscopy (PTCS) as a diagnostic and therapeutic endoscopical tool in 198 cases of malignant disease and 195 benign cases. After dilating the sinus tract of PTBD using a 15-Fr catheter about 2 weeks after PTBD, PTCS was carried out through the sinus tract. PTCS has diagnostic advantages: the lesion can be accurately diagnosed histologically and the extent of cancer in the biliary tract can be assessed by taking biopsy specimens before the operation. PTCS has been applied for cholangioscopic lithotripsy in 145 cases of gallstone disease. In 44 cases, the Nd-YAG laser and/or electrohydraulic shock wave has been used to break up the stones. The PTCS morbidity was 6% and mortality was 0.3%. 相似文献
58.
Identifying Predictors of Longitudinal Decline in the Level of Medical Care Received by Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study 下载免费PDF全文
Jacqueline Casillas M.D. M.S.H.S. Kevin C. Oeffinger M.D. Melissa M. Hudson M.D. Mark W. Yeazel M.D. M.P.H. Kirsten K. Ness P.T. Ph.D. Tara O. Henderson M.D. Leslie L. Robison Ph.D. Gregory T. Armstrong M.D. Qi Liu M.S. Wendy Leisenring Sc.D. Yutaka Yasui Ph.D. Paul C. Nathan M.D. M.Sc. 《Health services research》2015,50(4):1021-1042
59.
60.