全文获取类型
收费全文 | 2736篇 |
免费 | 136篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 50篇 |
儿科学 | 40篇 |
妇产科学 | 39篇 |
基础医学 | 317篇 |
口腔科学 | 38篇 |
临床医学 | 197篇 |
内科学 | 830篇 |
皮肤病学 | 118篇 |
神经病学 | 243篇 |
特种医学 | 53篇 |
外国民族医学 | 25篇 |
外科学 | 245篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 294篇 |
眼科学 | 13篇 |
药学 | 163篇 |
中国医学 | 10篇 |
肿瘤学 | 209篇 |
出版年
2023年 | 22篇 |
2022年 | 43篇 |
2021年 | 103篇 |
2020年 | 63篇 |
2019年 | 95篇 |
2018年 | 102篇 |
2017年 | 52篇 |
2016年 | 71篇 |
2015年 | 56篇 |
2014年 | 122篇 |
2013年 | 166篇 |
2012年 | 197篇 |
2011年 | 244篇 |
2010年 | 134篇 |
2009年 | 96篇 |
2008年 | 175篇 |
2007年 | 157篇 |
2006年 | 159篇 |
2005年 | 160篇 |
2004年 | 129篇 |
2003年 | 131篇 |
2002年 | 106篇 |
2001年 | 28篇 |
2000年 | 32篇 |
1999年 | 28篇 |
1998年 | 18篇 |
1997年 | 19篇 |
1996年 | 17篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 14篇 |
1991年 | 13篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 13篇 |
1983年 | 7篇 |
1982年 | 8篇 |
1981年 | 4篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1970年 | 2篇 |
1968年 | 3篇 |
1967年 | 2篇 |
排序方式: 共有2889条查询结果,搜索用时 15 毫秒
31.
32.
Sergi Mas Patricia Gassó Miquel Bernardo Amalia Lafuente 《European neuropsychopharmacology》2013,23(4):329-337
Risperidone is a potent antagonist of both dopamine and serotonin receptors. However, little is known about the underlying molecular mechanism by which risperidone acts. Although a number of genetic variants have been observed to correlate with treatment response there are no definitive predictors of response. We performed a genome-wide gene expression analysis (Human Genome U219 Array Plate) of a human neuroblastoma cell line (SK-N-SH) exposed to risperidone to identify molecular mechanisms involved in the cellular response to risperidone and thus identify candidate genes for pharmacogenetic studies. Our results revealed that cellular risperidone treatment is associated with a range of gene expression changes, which are time (6–48 h) and dose related (0.1–10 μM). We found that functional clusters of these changes correspond to Gene Ontology categories related to neural cell development functions, and synaptic structure and functions. We also identified Canonical Pathways related to these functional categories: neurogenesis and axon guidance; synaptic vesicle; and neurotransmitter signaling (dopamine, serotonin and glutamate). Finally, we identified candidate genes for pharmacogenetic studies related to the main risperidone secondary effects: motor disorders, cardiovascular disorders and metabolic disorders. Our results suggest that risperidone treatment affects the neurogenesis and neurotransmission of neuroblastoma cells, which is in agreement with the “initiation and adaptation” model to explain the mechanism of action of psychotropic drugs. 相似文献
33.
Impact of induction treatment before autologous stem cell transplantation on long‐term outcome in patients with newly diagnosed multiple myeloma
下载免费PDF全文
![点击此处可从《European journal of haematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
34.
Javier Vzquez-Bourgon Jaqueline Mayoral-van Son Marcos Gmez-Revuelta María Juncal-Ruiz Víctor Ortiz-García de la Foz Diana Tordesillas-Gutirrez Rosa Ayesa-Arriola Miquel Bioque Benedicto Crespo-Facorro 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2021,24(1):1
BackgroundPatients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort.MethodsA total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected.ResultsPatients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up.ConclusionsTreatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels. 相似文献
35.
36.
37.
Desirée Gutiérrez-Marín Joaquin Escribano Ricardo Closa-Monasterolo Natalia Ferré Michelle Venables Priya Singh Jonathan C.K. Wells Judit Muñoz-Hernando Marta Zaragoza-Jordana Mariona Gispert-Llauradó Carmen Rubio-Torrents Mireia Alcázar Mercè Núñez-Roig Raquel Monné-Gelonch Albert Feliu Josep Basora Ana M. Alejos Veronica Luque 《Clinical nutrition (Edinburgh, Scotland)》2021,40(3):1102-1107
38.
José Sanz-Santos Mireia Martínez-Palau Àngels Jaen Ramón Rami-Porta Bienvenido Barreiro Sergi Call Carme Obiols José Manuel González José Ángel De Marcos Montserrat Ysamat Lydia Canales Mireia Serra Josep Belda 《The Annals of thoracic surgery》2021,111(4):1190-1197
- Download : Download high-res image (252KB)
- Download : Download full-size image
39.
40.
Rosa A González-Polo José M Bravo-San Pedro Rubén Gómez-Sánchez Elisa Pizarro-Estrella Mireia Niso-Santano José M Fuentes 《British journal of pharmacology》2013,168(1):60-62
Huntington''s disease (HD) is a neurodegenerative disorder caused by a mutation in the gene encoding the huntingtin protein. Although the precise mechanism by which neuronal degeneration occurs is still unclear, several elements are important to its development: (1) altered gene expression and protein synthesis, (2) mitochondrial damage and (3) improper regulation of the autophagy programme. In this issue of British Journal of Pharmacology, Galindo and co-workers provide the first evidence for a role of the mitochondrial permeability transition pore (mPTP) in mitochondrial fragmentation and autophagy activation. In a model of cell death induced by 3-nitropropionic acid (3-NP) in human neural cells, the authors describe clear functions for mPTP and Bax, but not the mitochondrial fusion/fission machinery, mitochondrial fragmentation and autophagy (mitophagy). This commentary summarises the significance of this relationship and suggests several points for future development. 相似文献