全文获取类型
收费全文 | 7472篇 |
免费 | 306篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 80篇 |
儿科学 | 177篇 |
妇产科学 | 104篇 |
基础医学 | 1115篇 |
口腔科学 | 182篇 |
临床医学 | 369篇 |
内科学 | 2174篇 |
皮肤病学 | 140篇 |
神经病学 | 464篇 |
特种医学 | 261篇 |
外科学 | 1153篇 |
综合类 | 25篇 |
预防医学 | 176篇 |
眼科学 | 80篇 |
药学 | 463篇 |
中国医学 | 22篇 |
肿瘤学 | 826篇 |
出版年
2023年 | 24篇 |
2022年 | 47篇 |
2021年 | 113篇 |
2020年 | 80篇 |
2019年 | 113篇 |
2018年 | 109篇 |
2017年 | 102篇 |
2016年 | 125篇 |
2015年 | 117篇 |
2014年 | 195篇 |
2013年 | 279篇 |
2012年 | 460篇 |
2011年 | 498篇 |
2010年 | 270篇 |
2009年 | 233篇 |
2008年 | 466篇 |
2007年 | 531篇 |
2006年 | 575篇 |
2005年 | 566篇 |
2004年 | 510篇 |
2003年 | 472篇 |
2002年 | 471篇 |
2001年 | 76篇 |
2000年 | 66篇 |
1999年 | 81篇 |
1998年 | 154篇 |
1997年 | 106篇 |
1996年 | 93篇 |
1995年 | 73篇 |
1994年 | 66篇 |
1993年 | 73篇 |
1992年 | 51篇 |
1991年 | 58篇 |
1990年 | 48篇 |
1989年 | 46篇 |
1988年 | 37篇 |
1987年 | 37篇 |
1986年 | 21篇 |
1985年 | 28篇 |
1984年 | 25篇 |
1983年 | 19篇 |
1982年 | 25篇 |
1981年 | 32篇 |
1980年 | 36篇 |
1979年 | 15篇 |
1978年 | 18篇 |
1975年 | 19篇 |
1973年 | 16篇 |
1972年 | 13篇 |
1968年 | 15篇 |
排序方式: 共有7811条查询结果,搜索用时 93 毫秒
121.
122.
Masato Kiyoshi Minoru Tada Hiroko Shibata Michihiko Aoyama Akiko Ishii-Watabe 《Journal of pharmaceutical sciences》2021,110(3):1189-1196
Pre-filled syringes (PFS) have been in widespread use as an administration device for therapeutic antibodies in recent decades. Generally, the inner barrel and syringe of PFS are coated with silicone oil (SO) for lubrication. Multiple studies have focused on the fact that the SO adsorbs denatured antibody molecules, and induces antibody aggregation. Aggregated antibodies are recognized as a potential risk for evoking immunogenic responses in patients. The characteristics of the aggregated antibody-SO complexes, including their concentration, population, shape, three-dimensional (3D) image, and Fcγ Receptors (FcγRs) activation have been obscurely acknowledged so far. In the present work, we prepared aggregated antibody-SO complexes by agitation and analyzed using multifaceted techniques such as flow imaging, confocal fluorescence microscopy, and cell-based assays for FcγRs activation. The results emphasized that the SO accelerates the increase in sub-visible particles and antibody aggregation. The confocal fluorescence microscopy analysis revealed the high-resolution 3D images of aggregated antibody-SO complexes. The FcγRs reporter cell assay clarified that the pre-mixed and agitated Ab + SO have higher FcγRs activation capability compared to the agitated Ab. Overall, this study advances the view that SO has an effect to increase the risk of agitation-induced aggregated antibody particles. 相似文献
123.
124.
125.
Junya Sakamoto Yoshitaka Manabe Joichi Oyamada Hideki Kataoka Jiro Nakano Kazunobu Saiki Keishi Okamoto Toshiyuki Tsurumoto Minoru Okita 《Clinical anatomy (New York, N.Y.)》2018,31(5):705-709
Introduction : Referred pain in the anterior knee joint is the most common symptom in hip disease patients. The development of referred pain is considered to be related to dichotomizing peripheral sensory fibers. However, no gross anatomical findings identify any dichotomizing fibers innervating both the hip and knee joints. We dissected the femoral and obturator nerves in human cadavers to investigate the distribution of the articular branches in the hip and knee joints. Fourteen embalmed left lower limbs from 14 Japanese adult cadavers (five from females, nine from males, average age 73.8 ± 14.1 years) were observed macroscopically. The articular branches of the femoral and obturator nerves were dissected at the anterior margin of the groin toward the thigh region. After dissections of the articular nerves of the hip joints, the femoral and obturator nerves were exposed from proximally to distally to identify the articular nerves of the knee joints. The branching pattern of the articular branches in the hip and knee joints was recorded. In six of 14 limbs (42.9%), the femoral nerve supplied articular branches to the anteromedial aspect of both the hip and knee joints. These articular branches were derived from the same bundle of femoral nerve. These gross anatomical findings suggested that dichotomizing peripheral sensory fibers innervate the hip and knee joints and these could relate to the referred pain confirmed in the anterior knee joints of patients with hip disease. Clin. Anat. 31:705–709, 2018. © 2018 Wiley Periodicals, Inc. 相似文献
126.
127.
Takaharu Ikeda Tamihiro Kawakami Yoshihiro Arimura Naoko Ishiguro Akihiro Ishizu Fuyu Ito Toshiko Ito-Ihara Naoko Okiyama Sachiko Ono Kazuo Suzuki Koji Sugawara Mariko Seishima Masanari Kodera Maiko Tanaka Minoru Hasegawa Fukumi Furukawa Yukie Yamaguchi Ayumi Yoshizaki Revised Committee for guidelines for the management of vasculitis vascular disorders of the Japanese Dermatological Association 《The Journal of dermatology》2020,47(5):534-537
We developed a questionnaire to examine the findings of cutaneous arteritis among dermatological specialists experienced in vasculitis as certified by the Committee for guidelines for the management of vasculitis and vascular disorders of the Japanese Dermatological Association. We sent a questionnaire to 12 dermatological facilities identified through the revised Committee for guidelines for the management of vasculitis and vascular disorders of the Japanese Dermatological Association. Retrospective data obtained from 84 patients at the 12 dermatological facilities between 2012 January 2016 December were evaluated. The 84 patients were categorized into two groups, a systemic steroid treatment group (group 1, n = 52) and a no systemic steroid treatment group (group 2, n = 32). C-reactive protein in group 1 patients was significantly higher than that in group 2 patients. Frequency of fever, arthritis, myalgia- and peripheral neuropathy in group 1 was significantly higher than that in group 2. We propose that these symptoms could serve as early markers for the transfer from cutaneous arteritis to systemic polyarteritis nodosa. We further suggest that patients who are subsequently associated with cerebral hemorrhage and infarction, who are originally diagnosed as having cutaneous arteritis, could progress to systemic polyarteritis nodosa. The study demonstrated that it is important for dermatologists to detect these findings early in order to establish an accurate diagnosis and a timely treatment. 相似文献
128.
Fumitake ONO Shinichiro YASUMOTO Minao FURUMURA Takahiro HAMADA Norito ISHII Takashi GYOTOKU Mitsunari HIGUCHI Kenichiro INOKUCHI Kazuo JYO Hideaki KOGA Ayako KOMAI Koji MARUTA Tami MASHIKO Tsukasa MIHARA Hiroko MIYAHARA Minoru MIYASATO Koichiro MUTO Koichi NAGASE Masakazu NAGATA Hideki SAKIHAMA Tomoko TANAHASHI Atsuto UEDA Kyoko YAMAKAWA Chika OHATA Teruki DAINICHI Daisuke TSURUTA Takashi HASHIMOTO 《The Journal of dermatology》2012,39(11):902-908
Famciclovir is a guanine analog antiviral drug used commonly for herpes zoster. Efficacy of famciclovir treatment has been reported to be comparable to valacyclovir treatment. Both of these medications reduce the time to complete cessation of zoster‐associated pain including post‐herpetic neuralgia, as compared to acyclovir. We conducted a multicenter, randomized, open clinical trial in order to evaluate the extent of pain relief afforded by these two antiviral drugs during the acute disease phase of herpes zoster. The study group comprised 86 immunocompetent adult patients suffering from herpes zoster, who were treated with either famciclovir or valacyclovir for 7 days. Of these, 55 patients enrolled in this study within 72 h of the onset of the rash and 31 patients after 72 h of the onset. There was a significant reduction in acute herpes zoster pain with famciclovir on day 7 and at 2–3 weeks in both of these patient groups, while with valacyclovir, there was not significant reduction in pain on day 7. Of patients aged 50 years or older, there was a significantly earlier reduction in pain with famciclovir than with valacyclovir. In addition, a significant reduction in the number of patients with pain was observed as early as days 3–4 with famciclovir treatment as compared with valacyclovir treatment. We conclude that famciclovir was superior to valacyclovir in the relief of acute pain of herpes zoster. Accordingly, famciclovir is recommended for herpes zoster patients with moderate symptoms and a visual analog scale score of under 50 mm. 相似文献
129.
130.