心脏机械膜瓣置换术后血浆蛋白C和蛋白S活性变化及其与INR的关系

目的:探讨机械瓣膜置换术后口服华法令抗凝的患者血浆蛋白C(PC)、蛋白S(PS)活性改变的意义及其与国际标准IL比值(INR)的关系。方法:动态监测15例心脏机械瓣膜置换术后口服抗凝药初期患者服药1-2 d、3~10 d及1个月的PC、PS活性及INR值。结果:患者组PC、PS活性低于正常对照组(P<0.05),特别是术后3-10 d PC、PS活性明显低于正常对照组(P<0.01),已下降到正常的50％左右,而此时INR尚未达到治疗范围,提示口服抗凝药治疗初期在人体凝血功能未下调时,抗凝系统功能已经开始下降,有发生血栓的倾向;并且,随着抗凝强度的增高(INR低于1.5-高于2.5),PC、PS活性明显下降。结论:口服华法令抗凝患者在监测INR的同时,需要进行血浆PC、PS活性监测,以更好地预防血栓的发生。     

脑干、三叉神经及大脑动脉环的可视化研究

目的 建立人体脑干、三叉神经及大脑动脉环的可视化数字模型。方法 采用首例中国数字化可视人体数据集，在SGI工作站上对脑干及其周围毗邻结构进行计算机三维重建并立体显示。结果 获得人体脑干、三叉神经及大脑动脉环等器官组织的三维重建结构，可对其进行任意径线和角度的适时三维测量。结论 首例中国数字化可视人体数据集能够提供完整而精确的解剖断面数据，脑干及其毗邻的三叉神经、大脑动脉环的可视化模型准确反映出该区域复杂的解剖学结构特点及其相邻器官间的空间毗邻关系，可为该区域的疾病的影像诊断和外科治疗提供形态学依据。     

高血压病患者心肌灌注断层显像的相关因素研究

目的探讨高血压病患者心肌灌注断层显像的结果和多种临床因素的关系.方法将97例高血压病患者的心肌灌注断层显像结果同患者的年龄、性别、体重指数、患高血压病的时间、有无抗高血压治疗,有无高血压家族史,患者的血清葡萄糖、肌酐、尿素氮、甘油三酯、胆固醇、脉搏、收缩压、舒张压、脉压差、平均动脉压、患者是否吸烟、饮酒进行非条件Logistic回归分析.结果患高血压病的时间(βi=0.4914,P=0.0017)、吸烟(βi=3.5022,P=0.0176)、高胆固醇血症(βi=1.6147,P=0.0194)是高血压病患者并发心肌缺血的危险因素.结论高血压痛患者戒烟、治疗高胆固醇血症,可降低其并发心肌缺血的风险.     

简易立体定位仪定位微创治疗高血压脑出血

目的　探讨高血压脑出血微创治疗的方法和手术时机的选择对该病疗效的影响。方法　对 12例高血压脑出血患者 ,采用脑内血肿定位仪微创血肿穿刺引流术清除血肿 ,观察疗效。结果　ADL1～ 3级 75 % ,病死率 8.3%。结论　颅内血肿定位仪定位微创血肿穿刺引流术 ,具有效果肯定、定位准确、损伤轻微、适应症广的特点 ,超早期治疗是预后的关键     

Paired kidney analysis of tacrolimus and cyclosporine microemulsion-based therapy in Chinese cadaveric renal transplant recipients

Few studies used paired kidneys for comparison between tacrolimus and cyclosporine in renal transplantation. Most of the published data used whole blood trough levels for drug monitoring. However, the use of limited sampling strategy and abbreviated formula to estimate the 12-h area under concentration-time curve (AUC(0-12)) allowed better prediction of drug exposure. Sixty-six first cadaveric renal transplant recipients receiving paired kidneys were randomized to receive either tacrolimus-based (n = 33) or cyclosporine microemulsion (Neoral)-based therapies (n = 33). Abbreviated AUC(0-12) was used for drug monitoring and dose titration. Mean follow-up duration was 2.8 +/- 2 years. The patient and graft survival were comparable. Fewer incidence of acute rejection was observed in tacrolimus group (15% vs. 27.3%) though the difference was not significant (P = 0.23). The absolute value and the rate of decline of creatinine clearance were both significantly better in tacrolimus-treated patients. Prevalence of hypertension, post-transplant diabetes mellitus, infection, and malignancy were similar in both groups. Prevalence of hypercholesterolemia (11/33 vs. 4/33) and gum hypertrophy (6/33 vs. 1/33) was more common in cyclosporine-treated patients (P = 0.04 in both parameters). This was the first prospective, randomized study with paired kidney analysis showing the renal function was significantly better in tacrolimus-treated patients than in cyclosporine-treated patients.     

SURGICAL TREATMENT OF GYNECOLOGIC MALIGNANCES IN PATIENTS 70 YEARS OF AGE AND OLDER

Accordingtothedatafromepidemiology,thein-cidenceofcancerrisessteadilywithadvancingage.Age?specificincidenceratesfromtheThirdNationalCancerSurveyoftheUnitedStatesrevealedthattheriskofcancerdevelopmentinthe6thdecadeoflifeisapproximately1%,whichincreasesto2%inthe81styearoflife(1).Theincidencesofmostgyneco-logiccancersincludingcervicalcancer,endometrialcancer,ovariancancerandvulvarcancerpeakaftertheageof60years(2-4).Surgeryisoneofthemaintreatmentoptionsforgynecologiccancerandmaybringaboutsomeeff…     

吸烟对健康人血液流变学影响的观察

本文报道对59例健康吸烟者血液流变学9项指标的观察,并与非吸烟组进行比较。吸烟组的血小板粘附率、红细胞压积和全血粘度均较非吸烟组升高,差异非常显著(P<0.001)血浆比粘度在大量吸烟组升高,差异有显著性(P<0.05)说明吸烟使部份血粘滞因素升高,给血液的流变性带来不利影响。不同吸烟量的两组之间各项指标变化无显著差异。本文对发生机制及临床意义略加讨论。     

TiO2光触媒对流动采血车空气消毒与常规消毒效果的对比性研究

目的本课题主要是对TiO_2光触媒用于流动采血车空气消毒的可行性进行研究,探讨一种更适合街头流动采血车车内空气消毒的方法。方法通过跟踪监测,对比分析TiO_2光触媒对流动采血车空气消毒的效果。结果在采血车内喷涂TiO_2光触媒后,在自然光线下,将喷涂后的每一次空气监测结果分别与喷涂前的空气检测结果进行t检验,差异性非常显著(P<0.001);经过近三年的霉雨季节考验,空气当中的霉菌数为零。达到了《山东省固定采血点(室)、流动采血车基本标准》中规定的空气质量标准。     

橄榄油对单核吞噬细胞系统的影响

本文采用橄榄油皮下注射、观察其对小鼠腹腔单核吞噬细胞的游出、活化及吞噬功能。结果发现、橄榄油对上述功能均有明显的抑制作。