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排序方式: 共有290条查询结果,搜索用时 15 毫秒
91.
92.
E Mikus 《Zentralblatt für Chirurgie》1975,100(23):1432-1435
93.
K. W. Vietor C. Simon V. Malerczyk E. Pandel E. Dumke 《European journal of pediatrics》1974,117(3):175-182
In 6 healthy adults and in 10 small children with congenital heart defects and heart failure, the pharmacokinetics of ampicillin during and after continuous infusion (over a period of 4 hrs) were compared. There was no significant difference in biological half-life (on average 1 hr) between these two groups. In 5 children with transposition of the great arteries, ampicillin plasma levels during the 4th hr of continuous infusion were twice as high as in the other patients with hearts defects. In all patients ampicillin was excreted normally. In conclusion, then ampicillin may be given in normal dosages despite heart defects in small children. 相似文献
94.
95.
Vikas Prasad Aurora Sainz-Esteban Ruza Arsenic Ursula Plöckinger Timm Denecke Ulrich-Frank Pape Andreas Pascher Peter Kühnen Marianne Pavel Oliver Blankenstein 《European journal of nuclear medicine and molecular imaging》2016,43(9):1593-1600
Purpose
To explore the role of 68Ga-DOTATATE/DOTATOC PET/CT (SR PET/CT) in patients with suspicion of or histopathologically proven pancreatogenic hyperinsulinaemic hypoglycaemia.Methods
We included 13 patients with histopathologically proven or a high clinical suspicion of pancreatogenic hyperinsulinaemia. All the patients underwent a SR PET/CT scan. The results were correlated with histopathological findings. Normalization of blood glucose levels after resection of the pancreatic lesion, as well as a cytological and/or pathological diagnosis of insulinoma, was considered the diagnostic gold standard for insulinoma. The diagnosis of nesidioblastosis was based on exclusion of an insulinoma and conclusive pathological examination of a segment of the pancreas. Malignant insulinoma was defined as the presence of locoregional or distant metastases.Results
Based on histopathology, 13 patients were found to have pancreatic hyperinsulinaemia: two patients had malignant insulinoma, eight had nonmetastasized insulinoma, and three had nesidioblastosis. SR PET was positive in 11 of the 13 patients (84.6 %) with a final diagnosis of endogenous pancreatic hypoglycaemia. Histopathological staining confirmed 16 foci of hyperinsulinism (insulin positivity). SR PET detected 14 of the 16 lesions, resulting in a sensitivity of 87 %. One intrapancreatic spleen was falsely diagnosed as insulinoma focus on SR PET, resulting in positive predictive value of 93.3 %. Immunohistochemical staining of somatostatin receptor (SSR) subtype 2a was available in ten specimens: two nesidioblastosis, and seven benign and one malignant insulinoma. Eight out of the ten specimens (80 %) stained strongly to moderately positive. Seven of the eight SSR2a-positive lesions were picked up on SR PET. Based on the results of SR PET/CT, nine patients achieved complete remission of the hypoglycaemic events during follow-up.Conclusion
This explorative study suggests that SR PET in combination with CT may play a significant role in the detection and management of patients with pancreatogenic hyperinsulinaemic hypoglycaemia. A large proportion of insulinomas express SSR2a, and a larger study is needed to fully assess the diagnostic accuracy of SR PET in patients with insulinoma and nesidioblastosis compared with current localizing studies used in clinical practice.96.
Marák J Mikus P Maráková K Kaniansky D Valásková I Havránek E 《Journal of pharmaceutical and biomedical analysis》2008,46(5):870-876
The present work illustrates potentialities of on-line combined isotachophoresis-capillary zone electrophoresis (ITP-CZE) separation techniques coupled with on-capillary diode array detector (DAD) for enantiomeric purity testing of drugs in pharmaceuticals. The general advantages of the proposed method are its (i) high selectivity, (ii) low concentration limit of detection (LOD) obtainable, (iii) enhanced sample loadability, and (iv) enhanced reliability. For separation of brompheniramine (BP) enantiomers, serving as model analytes, carboxyethyl-β-cyclodextrin (CE-β-CD) was appropriate chiral selector providing complete enantioresolution. Given by a high sample load capacity (30 μl sample injection volume) and preconcentration of the analytes in ITP stage, concentration LOD of levobrompheniramine (LBP), serving as model impurity, was 2.5 ng/ml (8 × 10−9 mol/l). Such separation and detection conditions enabled to easily determine LBP in samples containing a 103 excess of dexbrompheniramine (DBP). DAD detection in comparison with single wavelength detection can enhance value of analytical information when analytes and interferents have different spectra (distinguishing impurities in analyte zone, confirmation of migration positions of migrants). In this context purity of BP zones was confirmed with higher reliability in pharmaceutical sample. Moreover, distinguishing the trace analyte signal superposed on the baseline noise was provided with sufficient reliability (for this purpose the background correction and smoothing procedure had to be applied to the raw DAD spectra). Successful validation and application of the proposed ITP-CZE-DAD method suggest its routine use for the enantiomeric purity testing of pharmaceuticals. 相似文献
97.
Hafner V Rutsch C Ding R Heinrich T Diedrichs L Schmidt-Gayk H Walter-Sack I Bommer J Mikus G 《International journal of clinical pharmacology and therapeutics》2008,46(3):131-135
OBJECTIVE: Secondary hyperparathyroidism in hemodialysis patients requires optimal correction of vitamin D deficiency with active vitamin D and analogues. It has been postulated that new vitamin D analogues, i.e. paricalcitol, efficiently suppress parathyroid hormone serum levels (PTH), but do not increase intestinal calcium absorption as much as calcitriol. The effects of calcitriol and paricalcitol on calcium balance can best be characterized under standardized conditions in healthy individuals with normal renal function, because the urinary calcium excretion at steady state corresponds to the net calcium absorption in the gut. METHODS: In a randomized, double-blind, placebo-controlled, 3-way crossover Phase I study in 13 healthy individuals we investigated the changes compared to placebo in PTH and urinary calcium excretion during 6-day treatment periods with paricalcitol (1.5 microg/day) and calcitriol (0.5 microg/day). RESULTS: 24-hour urinary calcium excretion was stable during 6 days of placebo administration. Neither paricalcitol nor calcitriol significantly changed calcium excretion. Urinary creatinine, magnesium and phosphate excretion also remained unchanged over the study periods irrespective of the treatment. However, calcitriol was shown to be effective in reducing iPTH levels during 6 days of treatment (mean reduction 4.03+/-0.69 pmol/l), whereas paricalcitol had no effect. CONCLUSION: Using a dosing ratio of 1:3 for calcitriol:paricalcitol, i.e. the same conversion factor used previously in studies on hemodialysis patients, only calcitriol was able to reduce iPTH levels in healthy individuals. Low-dose calcitriol reduced iPTH levels without raising calcium absorption and without including any hypercalcemia. 相似文献
98.
Harenberg J Jörg I Vukojevic Y Mikus G Weiss C 《European journal of clinical pharmacology》2008,64(6):555-563
Aim To gather information on anticoagulant effects after the termination of long-term therapy with idraparinux.
Methods The anticoagulant effects of idraparinux, a synthetic polymethylated analogue of its pentasaccharide, were analysed in 23
patients after termination of a 6- or 12-month therapy period for the prevention of recurrent venous thromboembolism (VTE).
Plasma samples of patients initially randomized to 2.5 mg idraparinux (normal creatinine clearance) or 1.5 mg idraparinux
(creatinine clearance <30 ml/min) were investigated in the van Gogh trials. At 3-month intervals for up to 15 months following
the termination of the therapy, the factor Xa-specific S2222 chromogenic substrate (aXa) assay and Heptest were used to determine
various pharmacokinetic parameters and prothrombin-induced clotting time (PiCT), activated partial thromboplastin time (aPTT)
and prothrombin time (PT) were determined.
Results Based on the aXa assay and Heptest, the half lives (t1/2) were 60.2 days and 107.7 days (p < 0.0001), maximum drug concentrations (Cmax) were 0.30 and 0.39 μg/l (p = 0.0016), areas under the activity time curve (AUC) were 33.7 and 38.0 μg/l per day (p = 0.0002), plasma clearances were 0.09 and 0.06 ml/min (p < 0.0001), mean residence times (MRT) were 75.4 and 121.9 (p < 0.0001) and volumes of distribution (Vdiss) were 7.4 and 8.6 l (p = 0.1336), respectively. After 12 months of treatment (n = 18), the S2222 and Heptest results showed significantly higher Cmax and AUC, lower Vdiss and clearance and unchanged t1/2
and MRT values compared to 6 months of treatment (n = 5). The PiCT was prolonged for a period of 9 months. Coagulation times of aPTT and PT were not influenced. The results
of these parameters did not differ between 12 and 6 months of treatment.
Conclusion The data support reports on a non-ionic binding of idraparinux to antithrombin and other proteins. We suggest that these findings
may explain some of the findings of the van Gogh Extension trial. 相似文献
99.
Arpesella G Mikus E Arabia M Loforte A Mikus PM 《The International journal of artificial organs》2007,30(7):604-610
Mechanical circulatory support is an essential issue in the management of patients with end-stage cardiac failure. The aim of this study is to evaluate the efficacy of temporary support with a centrifugal blood pump as bridge to heart function recovery or bridge to transplantation. Heart recovery is achieved by improving ventricular mechanical working conditions with proper modifications of preload and afterload. This article assesses the advantages of a novel 'cardiac chambers' cannulation setting versus the traditional one, in the case of biventricular or isolated right ventricular failure. The study was conducted using a numerical computer model based on the work by Guyton, Sagawa, Westerhof, and Noordergraaf. Simulation of the planned trials was achieved by changing the model parameters, the pump angular velocity, and the inflow and outflow settings. 相似文献
100.
Dorao P. Vazquez J. L. Ruza F. García S. Delgado M. A. Calvo C. Jennifer J. Verhoeven Jan A. Hazelzet Koen F. M. Joosten George Briassoulis Shekhar Venkataraman Ann Thompson Leite H. P. Iglesias S. Faria C. Ikeda A. Albuquerque M. P. Carvalho W. B. Paolo Cogo Giuseppe Giordano Tamara Badon Alberto Orzali Luc Zimmerman Pieter Sauer Virgilio Carnielli Champion M. P. Marsh M. J. Dalton R. N. Murdoch I. A. Morrison G. C. Sajjanhar T. Subir K. Chatterjee Sugato Banerjee 《Intensive care medicine》1996,22(2):S195-S196