Comparative study of 2 transplantable lines of murine L cells

A continuous line of mouse L cells chronically infected with SV5 paramyxovirus differs from mouse L0 cells free from this virus in the mitotic activity and karyologic features. The LSV5 line is characterized by inhibition of the mitotic activity, a decrease in the number of chromosomes and the presence of the marker chromosome. LSV5 and L0 cell cultures do not differ in the number of pathological mitoses, structural aberrations of chromosomes and the cytomorphological picture. The persisting SV5 virus can be detected in LSV5 line cultures by a number of methods (immunofluorescence, virological methods, etc.).     

低浓度胰岛素样生长因子Ⅱ可以预报正常体重2型糖尿病患者的体重增加

目的:胰岛素样生长因子(insulin-likegrowthfactor,IGF)-I与IGF-Ⅱ在代谢和生长调节中都发挥着重要的作用。先前我们报道过在血糖正常的正常体重个体中,低浓度IGF-Ⅱ预示着将来体重的增加。我们接着又研究了在2型糖尿病的情况下这一关系是否仍旧成立。方法:在为期5年的随访中,我们对224例2型糖尿病患者中基线时IGF-Ⅱ水平与体重增加风险(>2.0kg)之间的关系作了评估。结果:在随访期间有90位受试者(40.2%)体重增加高于2.0kg。对于基线时的受试者[体重指数(bodymassindex)<26],在体重增加高于2.0kg受试者的平均IGF-Ⅱ水平要显著低于体重…