全文获取类型
收费全文 | 2354篇 |
免费 | 129篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 71篇 |
妇产科学 | 43篇 |
基础医学 | 297篇 |
口腔科学 | 67篇 |
临床医学 | 189篇 |
内科学 | 540篇 |
皮肤病学 | 63篇 |
神经病学 | 274篇 |
特种医学 | 102篇 |
外科学 | 297篇 |
综合类 | 23篇 |
预防医学 | 109篇 |
眼科学 | 102篇 |
药学 | 157篇 |
中国医学 | 10篇 |
肿瘤学 | 141篇 |
出版年
2024年 | 4篇 |
2023年 | 31篇 |
2022年 | 50篇 |
2021年 | 77篇 |
2020年 | 40篇 |
2019年 | 55篇 |
2018年 | 83篇 |
2017年 | 55篇 |
2016年 | 68篇 |
2015年 | 65篇 |
2014年 | 96篇 |
2013年 | 105篇 |
2012年 | 172篇 |
2011年 | 207篇 |
2010年 | 119篇 |
2009年 | 90篇 |
2008年 | 149篇 |
2007年 | 174篇 |
2006年 | 168篇 |
2005年 | 143篇 |
2004年 | 133篇 |
2003年 | 146篇 |
2002年 | 113篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 15篇 |
1998年 | 14篇 |
1997年 | 15篇 |
1996年 | 8篇 |
1995年 | 8篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1992年 | 4篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1988年 | 8篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1978年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有2495条查询结果,搜索用时 15 毫秒
31.
Naito Y Tsujino T Kawasaki D Okumura T Morimoto S Masai M Sakoda T Fujioka Y Ohyanagi M Iwasaki T 《Journal of hypertension》2003,21(6):1107-1115
32.
Quantitation of basal dyssynchrony and acute resynchronization from left or biventricular pacing by novel echo-contrast variability imaging 总被引:4,自引:0,他引:4
Kawaguchi M Murabayashi T Fetics BJ Nelson GS Samejima H Nevo E Kass DA 《Journal of the American College of Cardiology》2002,39(12):2052-2058
OBJECTIVES: This study sought to test a novel echocardiographic method based on contrast variability imaging (CVI), to quantify cardiac dyssynchrony and magnitude of resynchronization achieved by left ventricular (LV) and biventricular (BiV) pacing therapy. BACKGROUND: Left ventricular or BiV pacing is a promising new therapy for patients with heart failure and intraventricular conduction delay. However, precise quantitation of the extent of resynchronization achieved remains scant. METHODS: Ten patients treated with BiV or LV pacing therapy were studied. Echo-contrast was infused slowly, and gated images were acquired before and during contrast appearance. The temporally normalized variance derived from 30 to 50 sequential beats was determined at each pixel to yield the CVI image-displaying improved wall delineation. Systolic regional fractional area of radial sectors was calculated with active and temporarily suspended (AAI) pacing. All analyses were performed blinded to both patient and treatment. RESULTS: Pacing increased septal inward motion from -20.4 +/- 9.6% to -30.5 +/- 14.0%, whereas lateral wall motion occurred earlier with no net magnitude change. Both spatial and temporal dyssynchrony in the LV declined nearly 40% with LV or BiV pacing (p < or = 0.001), and this correlated with increasing ejection fraction (31% to 39%; p < 0.02; p < 0.004 for correlation with dyssynchrony). CONCLUSIONS: The new imaging and regional dyssynchrony analysis methods provide quantitative assessment of resynchronization analogous to that previously obtained only by tagged magnetic resonance imaging. This could provide a useful noninvasive method for both identifying candidates and following long-term therapy. 相似文献
33.
Patrizio Caturegli Noel R Rose Miho Kimura Hiroaki Kimura Shey-Cherng Tzou 《Thyroid》2003,13(5):419-426
The pathogenesis of autoimmune diseases is frequently studied in murine models, in which disease outcome is traditionally assessed by light microscopy. To determine whether digital imaging improves reliability of the histopathologic assessment, and whether flow cytometry is applicable directly on the murine thyroid, we studied 395 CBA/J mice 3 weeks after thyroglobulin immunization, and 192 nonimmunized CBA/J mice. Digital imaging significantly improved reliability of the histopathological assessment (r = 0.988, 95% confidence interval: 0.980-0.992, p < 0.0001), and flow cytometry on the murine thyroid could be performed successfully. We also found that normal thyroids contained a higher than expected number of hematopoietic cells in the interstitium. We suggest that digital imaging offers a better means of estimating disease outcome, and that flow cytometry performed at the target organ levels reflects the autoimmune pathogenesis more closely than when performed on peripheral lymphoid organs. These methods should also be applicable to other organ systems targeted by autoimmune attack, such as heart, exocrine, and other endocrine glands. 相似文献
34.
Mari Terada Satoshi Kutsuna Tomiteru Togano Sho Saito Noriko Kinoshita Yumiko Shimanishi Tetsuya Suzuki Yusuke Miyazato Makoto Inada Takahito Nakamoto Hidetoshi Nomoto Satoshi Ide Mitsuhiro Sato Kenji Maeda Akihiro Matsunaga Masahiro Satake Keiji Matsubayashi Hirokazu Tsuno Makiko Kojima Madoka Kuramistu Kenta Tezuka Emi Ikebe Kazu Okuma Isao Hamaguchi Katsuyuki Shiratori Motohiko Sato Yuiko Kawakami Kumi Inaba Saori Igarashi Reina Yamauchi Mina Matsumura Keiko Ishimaru Bijuan Zhang Chika Kuge Maiko Ishihara Miho Gouda Keiko Tanaka Yukihito Ishizaka Norio Ohmagari 《Transfusion》2021,61(7):1998-2007
35.
Takeshi Saraya Michiaki Mikoshiba Harumi Kamiyama Masakazu Yoshizumi Shigeru Tsuchida Hiroyuki Tsukagoshi Taisei Ishioka Miho Terada Eiichi Tanabe Chizuko Tomioka Haruyuki Ishii Hirokazu Kimura Kunihisa Kozawa Tetsuo Shiohara Hajime Takizawa Hajime Goto 《Journal of clinical microbiology》2013,51(6):1979-1982
The present case provides direct evidence of human herpesvirus 6 reactivation in resected lymph node tissue in a patient with drug-induced hypersensitivity syndrome. This case clearly demonstrates that appropriate pathological evaluation of lymphadenopathy for drug-induced hypersensitivity syndrome, which mimics malignant lymphoma in clinical, radiological, and pathological findings, is required. 相似文献
36.
Riyo Ueda Yoshimi Kaga Yosuke Kita Miho Tanaka Masaki Iwasaki Eri Takeshita Yuko Shimizu-Motohashi Akihiko Ishiyama Takashi Saito Eiji Nakagawa Kenji Sugai Masayuki Sasaki Takashi Okada Masumi Inagaki 《Brain & development》2021,43(2):280-287
IntroductionAn alteration in postoperative cognitive function varies according to the patients’ background characteristics, such as etiology, focus, and seizure duration. Accurate prediction and assessment of postoperative cognitive function is difficult in each patient. Adaptive behavior could describe the typical performance of daily activities and represents the ability to translate cognitive potential into real-world skills. We examined the relationship between alterations of executive function (EF) and adaptive behavior in school children undergoing surgery for intractable epilepsy.MethodologyWe enrolled 31 children with focal resection or corpus callosotomy for intractable epilepsy [mean age at surgery, 12.5 years; 16 boys; mean intellectual quotient, 73.3]. We surveyed answered questionnaires on attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and adaptive behavior using the Vineland Adaptive Behavior Scale, 2nd edition (VABS-II), and performed continuous performance tests (CPTs) on children pre- and postoperatively.ResultADHD and ASD symptoms improved after epilepsy surgery. The omission error (OE) in the CPT variable improved after epilepsy surgery, especially in children with a shorter preoperative period. Improved ASD symptoms led to an increased score of the coping skills subdomain. The reduced OE observed after surgery also increased the score of the community skills subdomain.ConclusionImprovement in EF and ASD symptoms resulted in better adaptive behavior postoperatively. These results were important for the pre- and postoperative evaluation and re-evaluation of children with epilepsy requiring special education and related services. 相似文献
37.
38.
39.
Anna Wakui Hiroto Sano Miho Kawachi Ayaka Aida Yuta Takenaka Akane Yonezawa Nana Nakahata Sachie Moriyama Mayumi Nishikata Jumpei Washio Yuki Abiko Gen Mayanagi Keiko Yamaki Reiko Sakashita Kaori Tanaka Nobuhiro Takahashi Takuichi Sato 《Journal of oral biosciences / JAOB, Japanese Association for Oral Biology》2021,63(2):161-168
ObjectivesTo clarify the characteristics and growth of bacteria that may infiltrate liquid baby formula during feeding and after storage for more than 3 h, the transfer of oral bacteria through artificial nipples, and bacterial survival in liquid baby formula and a baby drink were examined immediately after drinking and after storage at 4 °C for 12 h and 24 h.MethodsThirteen human subjects (aged 19–24 years) were asked to drink approximately 50 mL of liquid baby formula and a baby drink, via the artificial nipple of a baby bottle. Samples of the remaining liquid after storage at 4 °C for 12 h and 24 h were inoculated onto blood agar plates and incubated anaerobically at 37 °C for 7 days. Genomic DNA was extracted from individual colonies, and the bacterial species were identified by 16S rRNA gene sequencing.ResultsThe mean concentrations of bacteria in the liquid baby formula were (2.6 ± 2.8) × 104 and (4.1 ± 6.6) × 104 colony-forming unit/mL after storage at 4 °C for 12 h and 24 h, respectively. Streptococcus (43.2%), Veillonella (9.3%), and Schaalia (8.2%) species were recovered from the remaining liquid baby formula after storage at 4 °C for 12 h. In contrast, no bacteria were detected in the remaining baby drink after storage at 37 °C for 24 h.ConclusionsThe levels of bacteria immediately after drinking and after storage at 4 °C for 12 h or 24 h were similar, suggesting that remaining liquid baby formula may be preserved safely in a refrigerator for more than 3 h. 相似文献