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Ryushi Shudo Takeshi Obara Satoshi Tanno Tsuneshi Fujii Noriyuki Nishino Miho Sagawa Hitoshi Ura Yutaka Kohgo 《Journal of gastroenterology》1998,33(2):289-294
"Groove pancreatitis", a form of segmental pancreatitis affecting the head of the pancreas, is local-ized within the "groove"
between pancreas head, duo-denum, and common bile duct. Differentiation between groove pancreatitis and pancreatic head carcinoma
is often difficult. We report a case of groove pancreatitis in which a hypoechoic mass between the duodenal wall and pancreas
was clearly imaged, and narrowing of the second portion of the duodenum and bile duct stenosis were also found. The diagnosis
was confirmed by surgery (pylorus-preserving pancreato duodenectomy). The patient was relieved from abdominal pain post operation.
Up to the present, the patient has been good condition. We review the clinicopathologic and radiologic features of groove
pancreatitis in the Japanese literature and discuss the possible role of Santorini's duct in its pathogenesis. We consider
that impacted protein plugs in Santorini's duct are a pathogenic factor in the development of groove pancreatitis. Therefore,
the findings of Santorini's duct on endoscopic retrograde pancreatography are very important in the diagnosis of groove pancreatitis.
Groove pancreatitis presents various clinical features, such as biliary stenosis, duodenal stenosis, and pancreatic mass,
and often masquerades as pancreatic head carcinoma. This condition should be kept in mind in the differential diagnosis of
pancreatic head carcinoma.
(Received Apr. 17, 1997; accepted Sept. 26, 1997) 相似文献
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Yusuke Nakade Tadashi Toyama Kengo Furuichi Shinji Kitajima Yoshiyasu Miyajima Mihiro Fukamachi Akihiro Sagara Yasuyuki Shinozaki Akinori Hara Miho Shimizu Yasunori Iwata Hiroyasu Oe Mikio Nagahara Hiroshi Horita Yoshio Sakai Shuichi Kaneko Takashi Wada 《Clinical and experimental nephrology》2015,19(5):909-917
76.
Hideo Wada Miho Sakakura Fumihiko Kushiya Masakatu Nisikawa Katsuya Onishi Kaname Nakatani Hiroshi Shiku Tsutomu Nobori 《Blood coagulation & fibrinolysis》2005,16(1):17-24
Thrombomodulin (TM) has been under development as a medicine for disseminated intravascular coagulation (DIC), and is expected to exhibit strong anticoagulant activity by inhibiting thrombin generation via the acceleration of protein C activation. In the present study, we examined the pharmacological action of TM in plasma obtained from DIC patients. TM was found to inhibit thrombin generation and accelerate activated protein C (APC) production at 0.3-30 TM units/ml in plasma obtained from DIC patients irrespective of their underlying disorders. In addition, there was a positive correlation between the inhibition of thrombin generation and the amount of APC produced. Thrombin generation was inhibited by over 50% when the plasma level of APC was increased by more than 0.2 microg/ml. These results indicate that TM inhibits thrombin generation in plasma obtained from DIC patients by accelerating APC production. Moreover, the results imply that the thrombin generation test may be a good method to speculate the efficacy of TM on every patient before the administration of TM. 相似文献
77.
Shinji Morimoto Yoshio Fujioka Hiroshi Hosoai Takahiro Okumura Miho Masai Tsuyoshi Sakoda Takeshi Tsujino Mitsumasa Ohyanagi Tadaaki Iwasaki 《Hypertension research》2003,26(4):315-323
Triglyceride-rich lipoproteins have been suggested to promote atherosclerosis. Plasminogen activator inhibitor type 1 (PAI-1) plays an important role in the events of cardiovascular pathophysiology. The renin-angiotensin system influences various vascular functions, including PAI-1 production. We examined whether or not chylomicron remnants increased PAI-1 mRNA and protein production in endothelial cells and whether or not an inhibition of the renin-angiotensin system interfered with this effect. Chylomicron remnants were isolated from functionally hepatectomized rats injected with chylomicrons. Human umbilical vein endothelial cell cultures (HUVECs) were incubated with chylomicron remnants with or without an angiotensin-converting enzyme inhibitor (temocaprilat), an angiotensin II receptor type 1 antagonist (RNH-6270), or an angiotensin II receptor type 2 antagonist (PD123319). Chylomicron remnants increased PAI-1 secretion in HUVECs (0.5 microg/ml; 128.3 +/- 6.1%, the mean +/- SEM) as well as angiotensin II (10 nmol/l; 130.7 +/- 9.5%) in 18 h, as compared with the controls, as well as stimulated PAI-1 mRNA expression to a maximum level at 4 h. Temocaprilat and RNH-6270, but not PD123319, attenuated all of these effects. Chylomicron remnants enhanced nuclear extract binding to a very low-density lipoprotein response element in the PAI-1 promoter region and activated nuclear factor-kappaB. Extracellular signal-regulated kinase (ERK 1/2) was phosphorylated in response to chylomicron remnants. These effects were inhibited by temocaprilat or RNH-6270. In conclusion, chylomicron remnants increased protein secretion and mRNA expression of PAI-1 in HUVECs. Inhibition of the renin-angiotensin system reduced this stimulation. 相似文献
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A Y-linked anti-Müllerian hormone duplication takes over a critical role in sex determination 总被引:2,自引:0,他引:2