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排序方式: 共有282条查询结果,搜索用时 53 毫秒
61.
Antje Micka Anne Siepelmeyer Anja Holz Stephan Theis 《International journal of food sciences and nutrition》2017,68(1):82-89
Constipation is among the most common health impairments in Western countries. This study aimed to determine the effect of the chicory-derived fermentable dietary fiber Orafti® Inulin on stool frequency in healthy subjects with constipation. The study was conducted according to recent guidance documents for investigating bowel function and used a randomized, double-blind, placebo-controlled, cross-over design with a 2-week wash-out phase. Each study period comprised a run-in phase followed by 4 weeks daily intake of 3?×?4g inulin or maltodextrin (placebo). Forty-four healthy volunteers with constipation documented stool frequency and consistency, gastrointestinal characteristics and quality of life. Consumption of Orafti® Inulin significantly increased stool frequency compared to placebo (median 4.0 [IQR 2.5–4.5] versus 3.0 [IQR 2.5–4.0] stools/week, p?=?0.038). This was accompanied by a softening of stools and trend toward higher satisfaction versus placebo (p?=?0.059). In conclusion, Orafti® Inulin was effective in volunteers with chronic constipation and significantly improved bowel function.Clinical trial registration: This trial was registered at clinicaltrials.gov as NCT02548247. 相似文献
62.
Marijn de Bruin Edwin J M Oberjé Wolfgang Viechtbauer Hans-Erik Nobel Mickaël Hiligsmann Cees van Nieuwkoop Jan Veenstra Frank J Pijnappel Frank P Kroon Laura van Zonneveld Paul H P Groeneveld Marjolein van Broekhuizen Silvia M A A Evers Jan M Prins 《The Lancet infectious diseases》2017,17(6):595-604
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Timothy H. Mungroop Bart F. Geerts Denise P. Veelo Timothy M. Pawlik Aurélie Bonnet Mickaël Lesurtel Koen M. Reyntjens Takehiro Noji Chao Liu Eduard Jonas Christopher L. Wu Eduardo de Santibañes Mohammed Abu Hilal Markus W. Hollmann Marc G. Besselink Thomas M. van Gulik 《Surgery》2019,165(2):337-344
Background
Fluid and pain management during liver surgery (eg, low central venous pressure) is a classic topic of controversy between anesthesiologists and surgeons. Little is known about practices worldwide. The aim of this study was to assess perioperative practices in liver surgery among and between surgeons and anesthesiologists worldwide that could guide the design of future international studies.Methods
An online questionnaire was sent to 22 societies, including 4 international hepatopancreatobiliary societies, the American Society of Anesthesiologists, and 17 other (inter-)national societies.Results
A total of 913 participants (495 surgeons and 418 anesthesiologists) from 66 countries were surveyed. A large heterogeneity in fluid management practices was identified, with 66% using low central venous pressure, 22% goal-directed fluid therapy, and 6% normovolemia. In addition, large heterogeneity was found regarding pain management practices, with 49% using epidural analgesia, 25% patient-controlled analgesia with opioids, and 12% regional techniques. Most participants assume that there is a relation between perioperative pain management and morbidity and mortality (78% of surgeons vs 89% of anesthesiologists; P < .001). Both surgeons and anesthesiologists have the highest expectations for minimally invasive surgery and enhanced recovery pathways for improving outcomes in liver surgery. No clear differences between continents were found.Conclusion
Worldwide there is a large heterogeneity in fluid and pain management practices in liver surgery. This survey identified several areas of interest for future international studies aiming to improve outcomes in liver surgery. 相似文献65.
Ali Pauline Labriffe Matthieu Paisant Paul Custaud Marc Antoine Annweiler Cédric Dinomais Mickaël 《Brain imaging and behavior》2022,16(1):228-238
Brain Imaging and Behavior - Patients with amnestic mild cognitive impairment (aMCI) present gait disturbances including slower speed and higher variability when compared to cognitively healthy... 相似文献
66.
Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms
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Micka?l Boyer Natalya Yutin Isabelle Pagnier Lina Barrassi Ghislain Fournous Leon Espinosa Catherine Robert Sa?d Azza Siyang Sun Michael G. Rossmann Marie Suzan-Monti Bernard La Scola Eugene V. Koonin Didier Raoult 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(51):21848-21853
Giant viruses such as Mimivirus isolated from amoeba found in aquatic habitats show biological sophistication comparable to that of simple cellular life forms and seem to evolve by similar mechanisms, including extensive gene duplication and horizontal gene transfer (HGT), possibly in part through a viral parasite, the virophage. We report here the isolation of “Marseille” virus, a previously uncharacterized giant virus of amoeba. The virions of Marseillevirus encompass a 368-kb genome, a minimum of 49 proteins, and some messenger RNAs. Phylogenetic analysis of core genes indicates that Marseillevirus is the prototype of a family of nucleocytoplasmic large DNA viruses (NCLDV) of eukaryotes. The genome repertoire of the virus is composed of typical NCLDV core genes and genes apparently obtained from eukaryotic hosts and their parasites or symbionts, both bacterial and viral. We propose that amoebae are “melting pots” of microbial evolution where diverse forms emerge, including giant viruses with complex gene repertoires of various origins. 相似文献
67.
Minoru Shinohara PhD Karim Sabra PhD Jean‐Luc Gennisson PhD Mathias Fink PhD Mickaél Tanter PhD 《Muscle & nerve》2010,42(3):438-441
A stand‐alone ultrasound shear wave imaging technology has been developed to quantify and visualize Young's modulus distribution by remotely applying ultrasound radiation force and tracking the resulting microvibrations in soft tissues with ultrafast ultrasound imaging. We report the first preliminary data that detected the distribution of local muscle stiffness within and between resting and contracting muscles at different muscle lengths with this technology. This technique may assist clinicians in characterizing muscle injuries or neuromuscular disorders. Muscle Nerve, 2010 相似文献
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D L Foster F J Ebling A F Micka L A Vannerson D C Bucholtz R I Wood J M Suttie D E Fenner 《Endocrinology》1989,125(1):342-350
The acute and long term effects of dietary restrictions on gonadotropin secretion were studied in ovariectomized female lambs. Nutritionally growth-restricted lambs which were chronically maintained at a body weight comparable to that at weaning (approximately 20 kg) became hypogonadotropic, exhibiting a low frequency of episodic LH discharges. Repeated administration of physiological doses of GnRH to these females at hourly intervals produced corresponding LH pulses, leading to the hypothesis that the dietary-induced hypogonadotropism arises from a deficiency in endogenous GnRH release, rather than an inability of the pituitary gland to secrete gonadotropins in response to hypothalamic stimulation. In such growth-restricted females receiving a single meal daily, initiation of ad libitum feeding led to a spontaneous LH pulse within 1 h. After 14 days of increased food intake, hourly LH pulses were evident; a marked reduction in LH pulse frequency was associated with the return to limited nutrition. No effects on pulse amplitude were evident. Changes in circulating FSH followed a pattern similar to that for LH, namely an increase in concentration with improved nutrition and a decrease with reduced nutrition. The rate of response of FSH secretion to these alterations in nutrition was slower than that for LH. PRL levels were not altered by changes in nutrition, and a clear annual rhythm of secretion was observed. GH concentrations changed inversely with the level of nutrition; high secretion was associated with periods of restricted feeding, and low secretion with increased nutrition. These findings indicate that dietary restriction in the developing female lamb depresses gonadotropin secretion without reducing other anterior pituitary gland secretions, such as PRL and GH. That these changes occur in the absence of the ovaries implies that metabolic and growth-related modulation of neuroendocrine function can occur independently of changes in sensitivity to the feedback actions of ovarian steroids and polypeptides. 相似文献