全文获取类型
收费全文 | 2840篇 |
免费 | 164篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 36篇 |
妇产科学 | 31篇 |
基础医学 | 351篇 |
口腔科学 | 55篇 |
临床医学 | 219篇 |
内科学 | 753篇 |
皮肤病学 | 143篇 |
神经病学 | 120篇 |
特种医学 | 161篇 |
外科学 | 446篇 |
综合类 | 11篇 |
预防医学 | 165篇 |
眼科学 | 89篇 |
药学 | 146篇 |
中国医学 | 3篇 |
肿瘤学 | 279篇 |
出版年
2022年 | 34篇 |
2021年 | 52篇 |
2020年 | 31篇 |
2019年 | 39篇 |
2018年 | 60篇 |
2017年 | 41篇 |
2016年 | 57篇 |
2015年 | 49篇 |
2014年 | 87篇 |
2013年 | 90篇 |
2012年 | 115篇 |
2011年 | 108篇 |
2010年 | 59篇 |
2009年 | 54篇 |
2008年 | 95篇 |
2007年 | 98篇 |
2006年 | 85篇 |
2005年 | 104篇 |
2004年 | 84篇 |
2003年 | 114篇 |
2002年 | 102篇 |
2001年 | 106篇 |
2000年 | 126篇 |
1999年 | 90篇 |
1998年 | 34篇 |
1997年 | 30篇 |
1996年 | 25篇 |
1994年 | 24篇 |
1993年 | 23篇 |
1992年 | 75篇 |
1991年 | 75篇 |
1990年 | 78篇 |
1989年 | 68篇 |
1988年 | 66篇 |
1987年 | 50篇 |
1986年 | 52篇 |
1985年 | 43篇 |
1984年 | 37篇 |
1983年 | 41篇 |
1982年 | 22篇 |
1979年 | 29篇 |
1977年 | 21篇 |
1974年 | 34篇 |
1973年 | 29篇 |
1972年 | 23篇 |
1971年 | 34篇 |
1970年 | 34篇 |
1969年 | 27篇 |
1968年 | 20篇 |
1967年 | 21篇 |
排序方式: 共有3018条查询结果,搜索用时 15 毫秒
51.
Postoperative bleeding risk after gastric endoscopic submucosal dissection during antithrombotic drug therapy 下载免费PDF全文
52.
Makoto Sugaya Kaoru Funamizu Michihiro Kono Yusuke Okuno Taisuke Kondo Ryusuke Ono Masashi Akiyama Chikako Nishigori Shinichi Sato 《The Journal of dermatology》2021,48(1):96-100
A case of xeroderma pigmentosum (XP) group D in a 39‐year‐old Japanese man is reported. The patient had suffered from moderate to severe solar sensitivity and freckle‐like pigmented macules in sun‐exposed areas since 6 years of age, and developed skin malignancies such as squamous cell carcinoma, actinic keratosis, Bowen’s disease and basal cell carcinoma. The minimal erythema dose for ultraviolet (UV) radiation was decreased with a delayed peak reaction. The level of unscheduled DNA synthesis of fibroblasts from the patient was 70% of normal, while they expressed POLH, a gene product responsible for the XP variant. Whole‐exome sequencing indicated that the patient harbored a homozygous mutation of c.1802G>T, p.Arg601Leu in ERCC2. A genetic complementation test was carried out by host cell reactivation assay, which showed that the patient’s fibroblasts recovered only when they were transfected with XPD cDNA, confirming the diagnosis of XP‐D. Arg601Leu mutation in ERCC2 may be related to mild UV radiation sensitivity and moderate skin lesions. 相似文献
53.
54.
55.
Le TA Chen J Changchien C Peterson MR Kono Y Patton H Cohen BL Brenner D Sirlin C Loomba R;for the San Diego Integrated NAFLD Research Consortium 《Hepatology (Baltimore, Md.)》2012,56(3):922-932
Bile acid sequestrants (BAS) lower plasma low density lipoprotein levels and improve glycemic control. Colestimide, a BAS, has been claimed by computed tomography to reduce liver fat. Therefore, we examined the efficacy of colesevelam, a potent BAS, to decrease liver fat in patients with biopsy-proven nonalcoholic steatohepatitis (NASH). Liver fat was measured by a novel magnetic resonance imaging (MRI) technique, the proton-density-fat-fraction (PDFF), as well as by conventional MR spectroscopy (MRS). Fifty patients with biopsy-proven NASH were randomly assigned to either colesevelam 3.75 g/day orally or placebo for 24 weeks. The primary outcome was change in liver fat as measured by MRI-PDFF in colocalized regions of interest within each of the nine liver segments. Compared with placebo, colesevelam increased liver fat by MRI-PDFF in all nine segments of the liver with a mean difference of 5.6% (P = 0.002). We cross-validated the MRI-PDFF-determined fat content with that assessed by colocalized MRS; the latter showed a mean difference of 4.9% (P = 0.014) in liver fat between the colesevelam and the placebo arms. MRI-PDFF correlated strongly with MRS-determined hepatic fat content (r(2) = 0.96, P < 0.0001). Liver biopsy assessment of steatosis, cellular injury, and lobular inflammation did not detect any effect of treatment. Conclusion: Colesevelam increases liver fat in patients with NASH as assessed by MRI as well as MRS without significant changes seen on histology. Thus, MRI and MRS may be better than histology to detect longitudinal changes in hepatic fat in NASH. Underlying mechanisms and whether the small MR-detected increase in liver fat has clinical consequences is not known. (HEPATOLOGY 2012;56:922-932). 相似文献
56.
Kenichi Kono Nagatsuki Tomura Ryo Yoshimura Tomoaki Terada 《Acta neurochirurgica》2013,155(8):1559-1563
Computational fluid dynamics (CFD) studies on cerebral aneurysms have attempted to identify surrogate hemodynamic parameters to predict rupture risk. We present a case of bilateral mirror image aneurysms, one of which ruptured soon after imaging. Wall shear stress values of the ruptured aneurysm changed by 20–30 % after rupture because of change in the aneurysm shape. Findings from our case suggest that CFD studies comparing unruptured and ruptured aneurysms may not yield valid estimation on aneurysm rupture risk because of changes in aneurysm shape after rupture. Changes in aneurysm shape after rupture should be considered in CFD research. 相似文献
57.
58.
Susumu Matsukuma Hiroaki Takeo Takako Kono Yuiko Nagata Kimiya Sato 《Histopathology》2012,61(5):857-862
Matsukuma S, Takeo H, Kono T, Nagata Y & Sato K (2012) Histopathology 61, 857–862 Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study Aims: This study has attempted to elucidate the clinicopathological features of aberrant cytokeratin 7 (CK7) expression by centrilobular hepatocytes. Methods and results: A total of 113 liver biopsy specimens from patients with common non‐neoplastic liver diseases, including hepatitis B or C, non‐alcoholic steatohepatitis, alcoholic liver disease and other diseases were examined. In 56 specimens (49.6%), CK7‐positive centrilobular hepatocytes (CK7 + CHs) were identified and sometimes showed binuclear features. CK7 + CHs were associated with patients’ older age (P = 0.004), higher serum levels of aspartate aminotransferase (P = 0.016) and γ‐glutamyltransferase (P = 0.006), centrilobular fibrosis (P < 0.001), prominent thickening of hepatocytic plates (P < 0.001) and higher scores of total and periportal CK7‐positive hepatocytes (both P < 0.001), but were not correlated with gender, steatosis, serum levels of total bilirubin or alanine aminotransferase. In 55 cases of hepatitis B and hepatitis C only, CK7 + CHs were related to a higher stage of fibrosis (P = 0.006). Conclusion: CK7 + CHs occur relatively frequently in non‐neoplastic liver disease, associated with centrilobular scarring and the presence of CK7‐positive periportal hepatocytes, and appear to be a non‐specific phenomenon with respect aetiology of underlying disease. CK7 + CHs may represent age‐dependent activation of hepatic progenitor cells or a regenerative phenomenon of hepatocytes themselves, both of which might contribute to liver regeneration. 相似文献
59.
Kentaro Nakai Kentaro Watanabe Shuhei Watanabe Rie Awata Keiji Kono 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2016,38(5):476-481
Background: Hypertension is a crucial risk factor for cardiovascular death and loss of residual kidney function. Absence of the nocturnal decline in blood pressure (BP) predicts cardiovascular events and poor prognosis. However, characteristics of hypertension in moderate-to-severe chronic kidney disease (CKD) have not been fully evaluated. We aimed to assess the circadian variation of BP and kidney survival in CKD patients. Methods: Patients who were examined by 24-h ambulatory BP monitoring (ABPM) and estimated glomerular filtration rate (eGFR), <45 ml/min/1.73 m2, were enrolled in the study. The impacts of BP circadian rhythm and brain natriuretic peptide (BNP) on kidney survival were evaluated. Results: A total of 124 patients were enrolled. The average age was 64 ± 14 years, 57% were male, and 43% had diabetes. Forty-five percent of patients had a non-dipper pattern, 35% had a riser pattern, 19% had a dipper pattern, and 1% had an extreme-dipper pattern. The prevalence of diabetes and plasma BNP levels was higher and eGFR was lower in the riser-pattern group than in the non-riser-pattern group. Kidney survival rates were significantly worse in the riser-pattern group than in the non-riser-pattern group (p < 0.05). Moreover, among riser and non-riser pattern groups divided by BNP levels, the riser group with higher BNP level showed the worst kidney survival (p < 0.05). Conclusion: The riser pattern is frequently associated with several conditions at higher risk for kidney survival. Patients with a rising pattern and higher BNP levels have a worse kidney prognosis. 相似文献
60.