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991.
Changes in the Expression of Circulating microRNAs in Systemic Lupus Erythematosus Patient Blood Plasma After Passing Through a Plasma Adsorption Membrane 下载免费PDF全文
Yusuke Ishibe Makio Kusaoi Go Murayama Takuya Nemoto Takayuki Kon Michihiro Ogasawara Kazuo Kempe Ken Yamaji Naoto Tamura 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2018,22(3):278-289
992.
Differential diagnosis of cholangiocarcinoma and IgG4‐related sclerosing cholangitis by fluorescence in situ hybridization using transpapillary forceps biopsy specimens 下载免费PDF全文
993.
Ryuta Shigefuku Tsunamasa Watanabe Takuro Mizukami Kotaro Matsunaga Nobuhiro Hattori Takuya Ehira Tatsuya Suzuki Hiroyasu Nakano Yoshinori Sato Yasumasa Matsuo Kazunari Nakahara Hiroki Ikeda Nobuyuki Matsumoto Takashi Tsuda Masafumi Katayama Satoshi Koizumi Chiaki Okuse Michihiro Suzuki Takehito Otsubo Takako Eguchi Nakajima Hiroshi Yasuda Fumio Itoh 《Clinical journal of gastroenterology》2018,11(6):487-492
Oxaliplatin, a chemotherapeutic agent for colorectal cancer, has been associated with pathological evidence of sinusoidal endothelial injury in the liver. However, esophagogastric varices are a poorly recognized outcome of oxaliplatin-based chemotherapy. We report a 78-year-old man, whose past history of colon cancer was resection and treatment with mFOLFOX6 for 20 weeks, as adjuvant chemotherapy. After 3.5-year follow-up of the oxaliplatin-based chemotherapy, he was diagnosed with esophageal varices without liver dysfunction, indicating that the hepatotoxicity caused by oxaliplatin could be prolonged after its administration. Patients who have received oxaliplatin-based chemotherapy should be followed up carefully over the long term. 相似文献
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Akiko Inoue Ryo Suzuki Keisuke Urabe Yutaro Kawamura Midori Masuda Kanta Kishi Kimitaka Takitani Hiroshi Katayama Hideki Tomiyama Michihiro Hayashi Shintaro Nemoto Kazuhisa Uchiyama Hiroshi Tamai 《Pediatric blood & cancer》2018,65(8)
Trisomy 18 is often fatal, but patients with this disease can now have longer survival due to proactive treatment intervention. However, hepatoblastomas may develop in these patients. In this study, we report four cases of hepatoblastoma associated with trisomy 18. All of the patients had congenital heart disease and three had undergone intracardiac surgical repair. Tumor growth was relatively slow in all cases, and there were no problems with chemotherapy tolerability and surgical resection. Three of the patients are currently disease‐free and the fourth is alive with remaining of the tumor. These cases suggest that combined chemotherapy and surgical resection may be an option to treat hepatoblastoma associated with trisomy 18 when cardiac pulmonary function is relatively stable. 相似文献
996.
Haruhiro Yamashita Kazunari Sugihara Chiaki Yamada Shunsuke Tsutsumi Yoshinobu Iwaki 《Experimental eye research》2010,90(5):591-363
The aim of this study is to investigate the effects of estrogen on functional changes in the retinas of streptozotocin (STZ)-induced diabetic rats by using an electroretinography. Female rats were randomly divided into four treatment groups: (1) Control (sham operation and vehicle administration); (2) STZ (sham operation and STZ administration); (3) OVX (ovariectomy and vehicle administration); and (4) OVX + STZ (ovariectomy and STZ administration). Full-field electroretinograms (ERGs) were recorded before OVX and STZ administration and 4 and 12 weeks after STZ administration. At 4 weeks after STZ administration, although there were no differences in the STZ and OVX groups compared with the Control group, the amplitude of the cone-response was significantly lower in the OVX + STZ group than in the Control group (P = 0.013). At 12 weeks after STZ administration, this response showed a similar tendency in the STZ and the OVX + STZ groups. At 12 weeks after STZ administration, the implicit times of OP3 and OP4 and of the cone-response were significantly delayed in the STZ and OVX + STZ groups (OP3: P = 0.030 and 0.050, OP4: P = 0.0060 and 0.0053, cone-response: P = 0.014 and 0.039), compared with in the Control group. Thus, the retinal functions in STZ-induced diabetic female rats were aggravated by OVX. OVX-induced estrogen deficiency resulted in earlier changes in the amplitudes of cone-response, especially in the diabetes, although this is a transient effect and it is difficult to explain. Recognizing the early neurosensory change would enable a better understanding of the effect of estrogen in the retina. 相似文献
997.
Seongah Han Chien-Ping Liang Marit Westerterp Takafumi Senokuchi Carrie L. Welch Qizhi Wang Michihiro Matsumoto Domenico Accili Alan R. Tall 《The Journal of clinical investigation》2009,119(4):1029-1041
Type 2 diabetes is associated with accelerated atherogenesis, which may result from a combination of factors, including dyslipidemia characterized by increased VLDL secretion, and insulin resistance. To assess the hypothesis that both hepatic and peripheral insulin resistance contribute to atherogenesis, we crossed mice deficient for the LDL receptor (Ldlr–/– mice) with mice that express low levels of IR in the liver and lack IR in peripheral tissues (the L1B6 mouse strain). Unexpectedly, compared with Ldlr–/– controls, L1B6Ldlr–/– mice fed a Western diet showed reduced VLDL and LDL levels, reduced atherosclerosis, decreased hepatic AKT signaling, decreased expression of genes associated with lipogenesis, and diminished VLDL apoB and lipid secretion. Adenovirus-mediated hepatic expression of either constitutively active AKT or dominant negative glycogen synthase kinase (GSK) markedly increased VLDL and LDL levels such that they were similar in both Ldlr–/– and L1B6Ldlr–/– mice. Knocking down expression of hepatic IR by adenovirus-mediated shRNA decreased VLDL triglyceride and apoB secretion in Ldlr–/– mice. Furthermore, knocking down hepatic IR expression in either WT or ob/ob mice reduced VLDL secretion but also resulted in decreased hepatic Ldlr protein. These findings suggest a dual action of hepatic IR on lipoprotein levels, in which the ability to increase VLDL apoB and lipid secretion via AKT/GSK is offset by upregulation of Ldlr. 相似文献
998.
Cornelis Blauwendraat Karl Heilbron Costanza L. Vallerga Sara Bandres‐Ciga Rainer von Coelln Lasse Pihlstrm Javier Simn‐Snchez Claudia Schulte Manu Sharma Lynne Krohn Ari Siitonen Hirotaka Iwaki Hampton Leonard Alastair J. Noyce Manuela Tan J. Raphael Gibbs Dena G. Hernandez Sonja W. Scholz Joseph Jankovic Lisa M. Shulman Suzanne Lesage Jean‐Christophe Corvol Alexis Brice Jacobus J. van Hilten Johan Marinus Johanna Eerola‐Rautio Pentti Tienari Kari Majamaa Mathias Toft Donald G. Grosset Thomas Gasser Peter Heutink Joshua M. Shulman Nicolas Wood John Hardy Huw R. Morris David A. Hinds Jacob Gratten Peter M. Visscher Ziv Gan‐Or Mike A. Nalls Andrew B. Singleton 《Movement disorders》2019,34(6):866-875
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1000.
Analysis of progressive ophthalmic lesion in a patient with subacute sclerosing panencephalitis 总被引:1,自引:0,他引:1
Zako M Kataoka T Ohno-Jinno A Inoue Y Kondo M Iwaki M 《European journal of ophthalmology》2008,18(1):155-158
PURPOSE: To evaluate the progressive lesions affecting the visual system in a patient with subacute sclerosing panencephalitis (SSPE). METHODS: The authors observed a 15-year-old boy with SSPE. Since the diagnosis was made before the appearance of ocular manifestations, the authors recorded the progressive ocular lesions using various ophthalmic examinations. RESULTS: The patient showed no ophthalmic abnormalities until he developed a left homonymous hemianopia with sudden bilateral disturbed visual acuity. Severe progressive macular lesions including a pigment epithelial window defect by fluorescein angiography, a marked decrease in foveal thickness by optical coherence tomography, and an extensive disorder mainly specific to cone cells in the central retina by electroretinography were demonstrated. Novel findings such as a transient relative afferent pupillary defect and an anterior uveitis were also observed. CONCLUSIONS: Analyses over a long period of time showed progressive ophthalmic findings in a patient with SSPE. 相似文献