我们对发生在急诊科的死亡病例了解多少？

目的：通过尸体解剖检查结果来观测临床死亡诊断与实际死凶之间的差异，本研究中的死亡病例均发生在急诊科并向苏格兰地方检查院上报，随后进行尸检。方法：这是在格拉斯哥某医院急诊科进行的一个为期1年的前瞻性研究，所有入选病例系来院前死亡和在急诊科死亡的患者。由有经验的急诊科医师在场判断死亡原因，然后与尸枪结果确定的真正死因进行对照，比较两者之间的差异。     

Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats.

Cerebral ischemic preconditioning protects against stroke, but is clinically feasible only when the occurrence of stroke is predictable. Reperfusion plays a critical role in cerebral injury after stroke; we tested the hypothesis that interrupting reperfusion lessens ischemic injury. We found for the first time that such postconditioning with a series of mechanical interruptions of reperfusion significantly reduces ischemic damage. Focal ischemia was generated by permanent distal middle cerebral artery (MCA) occlusion plus transient bilateral common carotid artery (CCA) occlusion. After 30 secs of CCA reperfusion, ischemic postconditioning was performed by occluding CCAs for 10 secs, and then allowing for another two cycles of 30 secs of reperfusion and 10 secs of CCA occlusion. Infarct size was measured 2 days later. Cerebral blood flow (CBF) was measured in animals subjected to permanent MCA occlusion plus 15 mins of bilateral CCA occlusion, which demonstrates that postconditioning disturbed the early hyperemia immediately after reperfusion. Postconditioning dose dependently reduced infarct size in animals subjected to permanent MCA occlusion combined with 15, 30, and 60 mins of bilateral CCA occlusion, by reducing infarct size approximately 80%, 51%, and 17%, respectively. In addition, postconditioning blocked terminal deoxynucleotidyl transferase-mediated uridine 5'-triphosphate-biotin nick end labeling-positive staining, a marker of apoptosis, in the penumbra 2 days after stroke. Furthermore, in situ superoxide detection using hydroethidine suggested that postconditioning attenuated superoxide products during early reperfusion after stroke. In conclusion, postconditioning reduced infarct size, most plausibly by blocking apoptosis and free radical generation. With further study it may eventually be clinically applicable for stroke treatment.     

霍奇金淋巴瘤组织中H／RS细胞与其背景细胞的微切割及其IgH基因重排检测

目的 从基因水平探讨霍奇金淋巴瘤(HL)组织中H／RS细胞(Hodgkin and Reed-Sternberg cells)是否起源于B细胞、H／RS细胞的克隆性以及与背景淋巴细胞的相互关系。方法 对33例经典霍奇金淋巴瘤(cHL)石蜡刮片组织进行IgH基因重排分析，并对其中6例重排阳性的病例经B细胞特异性激活蛋白(BSAP)免疫标记，将标记阳性的H／RS细胞和背景淋巴细胞进行微切割后进一步行IgH基因重排分析。结果 16例石蜡刮片组织IgH基因重排阳性。对6例经BSAP标记的cHL成功进行了微切割，其中19管H／RS细胞中，有14管出现重排阳性，细胞数目不同的各管阳性率无显著性差异(P=0．290)；12管背景淋巴细胞有2管出现重排阳性，H／RS细胞与背景淋巴细胞的阳性率有显著性差异(P=0．002)。结论 支持H／RS细胞来源于B细胞的理论，认为部分背景淋巴细胞可能具有瘤性增生活性，参与H／RS细胞的前体细胞组成。     

RNA-DNA杂交法研究乳酸脱氢酶-C基因在睾丸中特异性表达

用同位32~P标记乳酸脱氢酶-C(LDH-C)cDNA作为探针,与小鼠胸腺、脑、胰、心肌、骨骼肌、睾丸、肾、肺、肝的RNA以及人胰、皋丸、肝、骨骼肌、心肌及脑的RNA分别作点溃杂交(dot blot hybridization)及Northern印迹杂交,证实LDH-C基因只在睾丸中特异性表达。     

胎儿主要肢骨发育时间表──超声骨龄

用Ｂ超检测正常妊娠中的胎儿。选择受精龄为１２至３８整周（ｃｏｍｐｌｅｔｅｄｗｅｅｋ）的胎儿２９７例。测量其主要肢骨（干）长度。并将所测数据进行统计学处理。结果表明胎儿肢骨的生长发育与胎龄有显著的正相关关系。     

Effect of Captopril on Antithrombus Function of Endothelium

ＥｆｆｅｃｔｏｆＣａｐｔｏｐｒｉｌｏｎＡｎｔｉｔｈｒｏｍｂｕｓＦｕｎｃｔｉｏｎｏｆＥｎｄｏｔｈｅｌｉｕｍＸＩＯＮＧＹｉ－ｌｉ（熊一力）；ＺＨＡＯＨｕａ－ｙｕｅ（赵华月）（ＤｅｐａｒｔｍｅｎｔｏｆＭｅｄｉｃｉｎｅ，ＴｏｎｇｊｉＨｏｓｐｉｔａｌ，Ｔｏｎｇ...     

儿童糖尿病30例临床分析

30例儿童糖尿病患者年龄2～14岁,83.3％病前有感染史,起病多较急,年龄越小“三多一少”症状越不典型,多以酮症酸中毒昏迷就诊,其中20％被误诊。建议采用小剂量胰岛素静脉滴注治疗。     

β—环糊精高聚物对芳香类化合物包络吸附性能研究

选择酚类和芳香胺类化合物作为底物分子，研究了一类新型的β－环糊精高聚物（ＰＳ－ＰＧＭＡ－βＣＤ）对它们的包络吸附性能．结果表明．β－环糊精高聚物依据β－环糊精分子的包络作用，可以选择性地识别位置异构体．吸附容量与β－环糊精固载容量有关．     

两种MRI序列对听神经瘤成象的比较与评价

为选择中等场强的ＭＲＩ听神经瘤成像最佳序列。收集手术和病理证实的听神经瘤１３５例，分析序列Ⅰ、Ⅱ对内听道中心层面、三叉神经显示率及ＭＲ征象的显示情况。结果：序列Ｉ择内听道中心层面及三叉神经的显示均优于序列Ⅱ，序列Ⅱ在显示肿瘤内囊变、出血、不肿优于序列Ｉ；对肿瘤钙化、肿瘤血管、脑干移位的观察，两者相仿。结果显示：序列Ｉ在中等场经下作为听神经瘤成像的首选序列，并中运用到小脑角区ＭＲＩ成像。