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991.
992.
The prevalence of diet-induced migraine 总被引:2,自引:1,他引:1
RC Peatfield V Glover JT Littlewood M Sandler F Clifford Rose 《Cephalalgia : an international journal of headache》1984,4(3):179-183
Nineteen percent of about 490 patients with classical or common migraine reported that headaches can be precipitated by chocolate, 18% by cheese and 11% by citrus fruit, and a highly significant majority of these patients were sensitive to all three foods. Twenty-nine percent of the patients reported sensitivity to alcohol; again this was significantly associated with sensitivity to the three food stuffs, though a substantial number of patients were sensitive to alcohol but not foods. Thirty-one percent of 331 female patients believed that oral contraceptives precipitated headaches, but this could not be related to any dietary response. Patients with affected relatives were significantly more likely to report sensitivity to alcohol and chocolate; sensitivity to cheese and citrus fruit was less strongly related, and there was no relationship at all for oral contraceptives. These correlations suggest that food induced headaches are mediated by chemical constituents common to these foods. 相似文献
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Superficial Thrombophlebitis of the Breast in a Patient with an Arteriovenous Fistula for Hemodialysis 下载免费PDF全文
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Menezes R Bramante CM Garcia RB Letra A Carvalho VG Carneiro E Brunini S Oliveira RC Canova GC Moraes FG 《Journal of applied oral science : revista FOB》2004,12(2):104-107
Considering previous studies on the similarity between the chemical composition of the mineral trioxide aggregate and the Portland cement, the purpose of this study was to investigate the pulp response of dog's teeth after pulpotomy and direct pulp protection with MTA Angelus and white Portland cement. Thirty eight pulp remnants were protected with these materials. One hundred and twenty days after treatment, the animals were sacrificed and the specimens removed and prepared for histological analysis. Both materials demonstrated the same results when used as pulp capping materials, inducing hard tissue bridge formation and maintaining pulp vitality in all specimens. The MTA Angelus and the white Portland cement showed to be effective as pulp protection materials following pulpotomy. 相似文献
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MRP1 expression in CTCs confers resistance to irinotecan‐based chemotherapy in metastatic colorectal cancer 下载免费PDF全文
Emne Ali Abdallah Marcello Ferretti Fanelli Virgílio Souza e Silva Marcelo Calil Machado Netto José Luiz Gasparini Junior Daniel Vilarim Araújo Luciana Menezes Mendonça Ocea Marcilei Eliza Cavicchioli Buim Milena Shizue Tariki Vanessa da Silva Alves Victor Piana de Andrade Aldo Lourenço Abbade Dettino Celso Abdon Lopes de Mello Ludmilla Thomé Domingos Chinen 《International journal of cancer. Journal international du cancer》2016,139(4):890-898
Circulating tumor cells are important markers of tumor progression and can reflect tumor behavior in metastatic colorectal cancer (mCRC). Identification of proteins that confer resistance to treatment is an important step to predict response and better selection of treatment for patients. Multidrug resistance‐associated protein 1 (MRP1) and Multidrug resistance‐associated protein 4 (MRP4) play a role in irinotecan‐resistance, and Excision Repair Cross‐Complementation group 1 (ERCC1) expression can confer resistance to platinum compounds. Here, we included 34 patients with mCRC and most of them received FOLFIRI or FOLFOX chemotherapy (91.1%). CTCs were isolated by ISET® Technology and identified in 30 patients (88.2%), with a median of 2.0 CTCs/mL (0–31.0). We analyzed the immunocytochemical expression of MRP1, MRP4 and ERCC1 only in patients who had previously detectable CTCs, accordingly to treatment received (n = 19, 15 and 13 patients, respectively). Among patients treated with irinotecan‐based chemotherapy, 4 out of 19 cases with MRP1 positive CTCs showed a worse progression free survival (PFS) in comparison to those with MRP1 negative CTCs (2.1 months vs. 9.1 months; p = 0.003). None of the other proteins studied in CTCs had significant association with PFS. We analyzed also histological sections of primary tumors and metastases by immunohistochemistry, and found no association with clinicopathological characteristics or with PFS. Our results show MRP1 as a potential biomarker of resistance to treatment with irinotecan when found in CTCs from mCRC patients. This is a small proof‐of‐principle study and these early findings need to be validated in a larger cohort of patients. 相似文献
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The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism 下载免费PDF全文
Joana Peixoto Telmo A. Catarino Nathalia Cristina Campanella Weder Menezes Aline Paixão Becker Gisele Caravina de Almeida Marcus M. Matsushita Carlos Clara Luciano Neder Marta Viana‐Pereira Mrinalini Honavar Lígia Castro José Manuel Lopes Bruno Carvalho Rui Manuel Vaz Valdemar Máximo Paula Soares Manuel Sobrinho‐Simões Rui Manuel Reis Jorge Lima 《International journal of cancer. Journal international du cancer》2016,139(2):414-423
Human hotspot TERT promoter (TERTp) mutations have been reported in a wide range of tumours. Several studies have shown that TERTp mutations are associated with clinicopathological features; in some instances, TERTp mutations were considered as biomarkers of poor prognosis. The rs2853669 SNP, located in the TERT promoter region, was reported to modulate the increased TERT expression levels induced by the recurrent somatic mutations. In this study we aimed to determine the frequency and prognostic value of TERTp mutations and TERT rs2853669 SNP in 504 gliomas from Portuguese and Brazilian patients. TERTp mutations were detected in 47.8% of gliomas (216/452). Glioblastomas (GBM) exhibited the highest frequency of TERTp mutations (66.9%); in this glioma subtype, we found a significant association between TERTp mutations and poor prognosis, regardless of the population. Moreover, in a multivariate analysis, TERTp mutations were the only independent prognostic factor. Our data also showed that the poor prognosis conferred by TERTp mutations was restricted to GBM patients carrying the rs2853669 A allele and not in those carrying the G allele. In conclusion, the presence of TERTp mutations was associated with worse prognosis in GBM patients, although such association depended on the status of the rs2853669 SNP. The status of the rs2853669 SNP should be taken in consideration when assessing the prognostic value of TERTp mutations in GBM patients. TERTp mutations and the rs2853669 SNP can be used in the future as biomarkers of glioma prognosis. 相似文献