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101.
目的:探讨甘氨双唑钠(CMNa)对III期肺癌的放射增敏作用及不良反应。方法:采用随机分组的方法将经病理学确诊的Ⅲ期非小细胞肺癌(NSCLC)患者分为实验组(A组,放疗加甘氨双唑钠)及对照组(B组,单纯放疗)。两组放疗方法均一样。A组在放疗同时,加用CMNa(800mg/m^2),每周3次,至疗程结束;B组为单纯放疗,评价两组疗效及观察不良反应。结果:A组的CR+PR为82.6%(19/23),显著高于B组的52.2%(12/23),P〈0.05,差异有统计学意义。两组的不良反应比较,P〉0.05,差异无统计学意义。结论:甘氨双唑钠对局部晚期非小细胞肺癌有放射增敏作用.可提高有效率(CR+PR),但不增加不良反应。 相似文献
102.
目的:分析两种标准空腹血糖受损人群葡萄糖负荷后血糖代谢特点。方法:对3828名40岁以上居民进行流行病学调查,对空腹血糖≥5.6mmol/L者行75g葡萄糖负荷试验,据不同空腹血糖受损诊断标准分析负荷后2h血糖代谢情况。结果:在以空腹血糖为6.1mmol/L为切点诊断的245例空腹血糖受损(IFG)人群中,糖耐量减低(IGT)的患病率为41.22%,女性(25.71%)高于男性(15.51%);2型糖尿病(T2DM)患病率为20.82%,女性(11.84%)高于男性(8.98%)。在以空腹血糖为5.6mmol/L为切点诊断的627例空腹血糖受损人群中,糖耐量减低的患病率为37.00%,女性(23.76%)高于男性(13.23%);2型糖尿病患病率为13.88%,女性(9.52%)高于男性(4.63%)。结论:以空腹血糖为5.6mmol/L和6.1mmol/L为切点诊断的空腹血糖受损人群葡萄糖负荷后2h血糖代谢异常率分别为50.88%和62.04%,患病率女性均高于男性。 相似文献
103.
目的:探讨泌尿生殖道支原体感染及耐药情况,为临床治疗提供合理、科学的抗生素用药依据.方法:应用支原体培养鉴定药敏试剂盒检测从患者中分离培养的支原体对10种抗生素的药敏情况,并对结果进行分析.结果:2 137例患者中1 163例支原体阳性,阳性率为54.42%;其中女性标本中阳性率为59.58%、男性标本中阳性率为38.78%,女性感染率明显高于男性,Uu、Mh、Uu+Mh阳性率分别为41.18%(880/2137)、3.88%(83/2137)、9.36%(200/2137),以Uu感染率最高,对Uu敏感率最高的抗生素为强力霉素,耐药率最高者为环丙沙星.结论:泌尿生殖道支原体的感染相当普遍,以Uu阳性率最高,女性高于男性,其耐药性已相当严重,应引起临床重视. 相似文献
104.
Not only does breast milk provides an ideal nutrient composition for the newborn, but it also contains a variety of substances that may actively influence growth and development of the infant and stimulate neonatal protection against gastrointestinal diseases. Hormones, growth factors, cytokines and even whole cells are present in breast milk and act to establish biochemical and immunological communication between mother and child. In addition, milk nutrients such as nucleotides, glutamine and lactoferrin have been shown to influence gastrointestinal development and host defense. The unique properties of milk as a mediator of biochemical messages will be presented and the clinical significance of breastfeeding in the prevention of neonatal gastrointestinal diseases will be discussed. 相似文献
105.
BACKGROUND: Studies of fetal cocaine exposure and newborn neurologic function have obtained conflicting results. Although some studies identify abnormalities, others find no differences between cocaine-exposed and cocaine-unexposed infants. To determine the effects of prenatal cocaine exposure on intrauterine growth and neurologic function in infants, we prospectively evaluated 253 infants shortly after birth. METHODS: Women who delivered a live singleton >36 weeks by dates were eligible for enrollment. Maternal exclusionary criteria were known parenteral drug use, alcoholism, and acquired immunodeficiency syndrome; infant exclusionary criteria were Apgar scores =4 at 5 minutes, obvious congenital malformations, seizures, or strokes. A total of 98% of infants were evaluated between 1 to 7 days of age. Newborns were assessed with the Neurological Examination for Children (NEC) by a pediatric neurologist (C.A.C.) who was blinded to exposure status. Gestational age was determined by Ballard's examination. Cocaine exposure was determined for the last trimester by radioimmunoassay of maternal hair (RIAH). Exposure values ranged from 2 to 4457 ng/10 mg hair. Infants were excluded if a maternal hair sample was missing (N = 13). The sample comprises 240 woman and infant pairs-104 cocaine-exposed and 136 cocaine-unexposed. RESULTS: Compared with unexposed controls, cocaine-exposed infants exhibited higher rates of intrauterine growth retardation (24% vs 8%), small head circumference ([HC] <10th% percentile) (20% vs 5%) and neurologic abnormalities: global hypertonia (32% vs 11%), coarse tremor (40% vs 15%), and extensor leg posture (20% vs 4%). We found increasing odds (odds ratio) of growth and neurologic impairment with increasing level of cocaine exposure in stratified analyses. The odds ratio associated with three levels of cocaine exposure (no exposure, low exposure = RIAH 2-66 ng/mg; and high exposure = RIAH 81-4457 ng/mg) respectively are: 1.0, 3.3, and 6.1 for small head size (chi2 for trend); 1.0, 3. 3, and 4.3 for global hypertonia (chi2 for trend); 1.0, 3.4, and 7.4 for extensor leg posturing (chi2 for trend); and 1.0, 3.8, and 3.8 for coarse tremor (chi2 for trend). Significant associations between cocaine exposure and neurologic signs were found in logistic regression equations that controlled for 20 or more variables. CONCLUSION: We conclude that adverse neonatal effects associated with fetal cocaine exposure follow a dose-response relationship: newborns with higher levels of prenatal cocaine exposure show higher rates of impairments in fetal head growth and abnormalities of muscle tone, movements, and posture. Significant relationships between cocaine exposure and these outcomes remain in controlled analyses. 相似文献
106.
Proximal segment histology of resected bowel in Hirschsprung's disease predicts postoperative bowel function. 总被引:1,自引:0,他引:1
The authors present an overview of 101 patients operated for Hirschsprung's disease by Rehbein procedure. Special attention is directed to the histomorphological findings in the proximal segment of the resected bowel specimens. A strong link was confirmed between these specific features and postoperative bowel function. A histologically regular proximal bowel segment generally predicted good postoperative bowel function with a constipation rate of 10.5%. In patients with intestinal neuronal dysplasia (IND) of the proximal segment the overall clinical result remained unchanged, although the constipation rate rose to 17.8%. Postoperative bowel function was seriously affected in cases characterized by proximal segment hypoganglionosis with a constipation rate of 23.1% and an additional 7.7% with encopresis. Finally, the distinct group of children with aganglionosis of the proximal segment followed a complicated postoperative course with secondary bowel resections and recurrent episodes of enterocolitis. In addition, the authors state their general observation that histological findings become less important whenever a more extensive resection than left hemicolectomy is required. Discussing the results, guidelines are given to further patient treatment once the particular proximal segment histology is diagnosed. 相似文献
107.
目的:明确切牙管区的解剖结构,为鼻缺失后种植体支持的赝复体修复提供依据,以明确种植钉植入部位及方向。方法:对60例正常咬合人群的上颌骨进行64排螺旋CT扫描和三维重建,观察切牙管开口的形状及周围骨质形态,并在中切牙之间的矢状位截面上测量切牙管的长度、鼻腔和口腔开口的纵径、与鼻底平面所成角度及与牙槽骨前壁的距离。结果:研究得出了切牙管口腔开口的形态、平均长度、口腔和鼻腔开口的矢状径、切牙管口腔开口和鼻腔开口距牙槽骨前壁的距离、切牙管前壁与鼻底平面的交角∠α、上前牙牙槽突与鼻底平面的交角∠β。结论:切牙管与牙槽骨前壁之间可植入直径5mm以内的种植体1枚,方向由后上方向前下方,与鼻底所成的角度介于∠α与∠β之间;双侧中切牙之间水平向可植入长度<5mm的种植体1枚。 相似文献
108.
DL Domingo MI Trujillo SE Council MA Merideth LB Gordon T Wu WJ Introne WA Gahl TC Hart 《Oral diseases》2009,15(3):187-195
Objective: Hutchinson-Gilford progeria syndrome (HGPS) is a rare early-onset accelerated senescence syndrome. In HGPS, a recently identified de novo dominant mutation of the lamin A gene ( LMNA ) produces abnormal lamin A, resulting in compromised nuclear membrane integrity. Clinical features include sclerotic skin, cardiovascular and bone abnormalities, and marked growth retardation. Craniofacial features include 'bird-like' facies, alopecia, craniofacial disproportion, and dental crowding. Our prospective study describes dental, oral soft tissue, and craniofacial bone features in HGPS.
Methods: Fifteen patients with confirmed p.G608G LMNA mutation (1–17 years, seven males, eight females) received comprehensive oral evaluations. Anomalies of oral soft tissue, gnathic bones, and dentition were identified.
Results: Radiographic findings included hypodontia ( n = 7), dysmorphic teeth ( n = 5), steep mandibular angles ( n = 11), and thin basal bone ( n = 11). Soft tissue findings included ogival palatal arch ( n = 8), median sagittal palatal fissure ( n = 7), and ankyloglossia ( n = 7). Calculated dental ages (9 months to 11 years 2 months) were significantly lower than chronological ages (1 year 6 months to 17 years 8 months) ( P = 0.002). Eleven children manifested a shorter mandibular body, anterior/posterior cranial base and ramus, but a larger gonial angle, compared to age/gender/race norms.
Conclusion: Novel oral-craniofacial phenotypes and quantification of previously reported features are presented. Our findings expand the HGPS phenotype and provide additional insight into the complex pathogenesis of HGPS. 相似文献
Methods: Fifteen patients with confirmed p.G608G LMNA mutation (1–17 years, seven males, eight females) received comprehensive oral evaluations. Anomalies of oral soft tissue, gnathic bones, and dentition were identified.
Results: Radiographic findings included hypodontia ( n = 7), dysmorphic teeth ( n = 5), steep mandibular angles ( n = 11), and thin basal bone ( n = 11). Soft tissue findings included ogival palatal arch ( n = 8), median sagittal palatal fissure ( n = 7), and ankyloglossia ( n = 7). Calculated dental ages (9 months to 11 years 2 months) were significantly lower than chronological ages (1 year 6 months to 17 years 8 months) ( P = 0.002). Eleven children manifested a shorter mandibular body, anterior/posterior cranial base and ramus, but a larger gonial angle, compared to age/gender/race norms.
Conclusion: Novel oral-craniofacial phenotypes and quantification of previously reported features are presented. Our findings expand the HGPS phenotype and provide additional insight into the complex pathogenesis of HGPS. 相似文献
109.
Oddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE Katsnelson M Pukenas B Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD 《中华神经外科疾病研究杂志》2011,(5):452-452
Background:Brain hypoxia(BH)can aggravate outcome after severe traumatic brain injury(TBI).Whether BH or reduced brain oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully elucidated.Objective To analyze the relationship between Pbto2,intracranial pressure(ICP),and cerebral perfusion pressure(CPP)and to examine whether BH correlates with worse outcome independently of ICP and CPP.Methods We studied103patients monitored 相似文献
110.
多重PCR法检测金黄色葡萄球菌耐药基因及致病毒素基因 总被引:1,自引:0,他引:1
目的:了解金黄色葡萄球菌(简称金葡菌)耐药基因及所携带致病毒素基因PVL与TSST-1的特点。方法:应用多重PCR法检测mecA基因、TSST-1基因及Py£基因。结果:84株金 葡球经多重PCR法对其mecA基因进行检测.检出率为58.3%(49/84)。PVL基因阳性菌株的分离率为23.8%(20/84),州£阳性的MRSA为13株(13/49,26.5%),PyL阳性的MSSA为7株(7/35,20.O%),差异无统计学意义(P〉0.05);未检出TSST-1基因。结论:金葡菌的耐药性呈上升趋势,且金葡菌可产生多种毒素,在分离金葡菌的同时,应加强其耐药基因及毒素基因的检测。 相似文献