全文获取类型
收费全文 | 5749篇 |
免费 | 318篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 52篇 |
儿科学 | 336篇 |
妇产科学 | 75篇 |
基础医学 | 655篇 |
口腔科学 | 114篇 |
临床医学 | 570篇 |
内科学 | 1248篇 |
皮肤病学 | 85篇 |
神经病学 | 494篇 |
特种医学 | 136篇 |
外科学 | 1013篇 |
综合类 | 139篇 |
一般理论 | 3篇 |
预防医学 | 316篇 |
眼科学 | 149篇 |
药学 | 320篇 |
中国医学 | 15篇 |
肿瘤学 | 363篇 |
出版年
2023年 | 59篇 |
2022年 | 77篇 |
2021年 | 187篇 |
2020年 | 118篇 |
2019年 | 162篇 |
2018年 | 193篇 |
2017年 | 134篇 |
2016年 | 163篇 |
2015年 | 148篇 |
2014年 | 232篇 |
2013年 | 241篇 |
2012年 | 418篇 |
2011年 | 454篇 |
2010年 | 230篇 |
2009年 | 221篇 |
2008年 | 337篇 |
2007年 | 314篇 |
2006年 | 311篇 |
2005年 | 264篇 |
2004年 | 261篇 |
2003年 | 262篇 |
2002年 | 224篇 |
2001年 | 120篇 |
2000年 | 116篇 |
1999年 | 99篇 |
1998年 | 49篇 |
1997年 | 37篇 |
1996年 | 29篇 |
1995年 | 19篇 |
1994年 | 28篇 |
1993年 | 23篇 |
1992年 | 45篇 |
1991年 | 38篇 |
1990年 | 35篇 |
1989年 | 33篇 |
1988年 | 37篇 |
1987年 | 20篇 |
1986年 | 24篇 |
1985年 | 37篇 |
1984年 | 27篇 |
1983年 | 24篇 |
1982年 | 20篇 |
1981年 | 15篇 |
1980年 | 13篇 |
1979年 | 22篇 |
1978年 | 17篇 |
1977年 | 16篇 |
1975年 | 12篇 |
1974年 | 17篇 |
1971年 | 16篇 |
排序方式: 共有6083条查询结果,搜索用时 15 毫秒
61.
Heart failure (HF) is the most common cause of hospitalization and rehospitalization among those 65 years and older. Effective HF self-management is recommended for reducing readmissions. This pilot study, through a one-group, pretest-posttest design, examines the effects of nurse-guided, patient-centered HF education on readmissions among older adults (n?=?26) in a post-acute care unit. All selected participants received 3 sessions of tailored patient education. Their knowledge and self-care skills were measured pre- and post-intervention with the Atlanta Heart Failure Knowledge Test (A-HFKT) and the Self-Care of Heart Failure Index (SCHFI). Patients' HF-related knowledge and self-care skills showed statistically significant improvements, and only 1 patient was rehospitalized for any HF-related reason within 30 days post-discharge. These results suggest that HF rehabilitation teams could support better patient outcomes by assigning nursing staff to provide individualized patient education, as this can help ensure that patients understand discharge instructions for effective self-care. 相似文献
62.
Monique Lhussier HND MSc PhD Simon Eaton BMedSci BMBS FRCP DM CertMEd Natalie Forster BA PGCert Mathew Thomas BA Sue Roberts MBBS MSc FRCP Susan M Carr BA MSc PhD 《Health expectations》2015,18(5):605-624
Objective
This article focuses on approaches within clinical practice that seek to actively involve patients with long‐term conditions (LTCs) and how professionals may understand and implement them. Personalized care planning is one such approach, but its current lack of conceptual clarity might have impeded its widespread implementation to date. A variety of overlapping concepts coexist in the literature, which have the potential to impair both clinical and research agendas. The aim of this article is therefore to explore the meaning of the concept of care planning in relation to other overlapping concepts and how this translates into clinical practice implementation.Methods
Searches were conducted in the Cochrane database for systematic reviews, CINHAL and MEDLINE. A staged approach to conducting the concept mapping was undertaken, by (i) an examination of the literature on care planning in LTCs; (ii) identification of related terms; (iii) locating reviews of those terms. Retrieved articles were subjected to a content analysis, which formed the basis of our concept maps. (iv) We then appraised these against knowledge and experience of the implementation of care planning in clinical practice.Results and Conclusions
Thirteen articles were retrieved, in which the core importance of patient‐centredness, shared decision making and self‐management was highlighted. Literature searches on these terms retrieved a further 24 articles. Our concept mapping exercise shows that whilst there are common themes across the concepts, the differences between them reflect the context and intended outcomes within clinical practice. We argue that this clarification exercise will allow for further development of both research and clinical implementation agendas. 相似文献63.
James W Murrough Katherine E Burdick Cara F Levitch Andrew M Perez Jess W Brallier Lee C Chang Alexandra Foulkes Dennis S Charney Sanjay J Mathew Dan V Iosifescu 《Neuropsychopharmacology》2015,40(5):1084-1090
The glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine displays rapid antidepressant effects in patients with treatment-resistant depression (TRD); however, the potential for adverse neurocognitive effects in this population has not received adequate study. The current study was designed to investigate the delayed neurocognitive impact of ketamine in TRD and examine baseline antidepressant response predictors in the context of a randomized controlled trial. In the current study, 62 patients (mean age=46.2±12.2) with TRD free of concomitant antidepressant medication underwent neurocognitive assessments using components of the MATRICS Consensus Cognitive Battery (MCCB) before and after a single intravenous infusion of ketamine (0.5 mg/kg) or midazolam (0.045 mg/kg). Participants were randomized to ketamine or midazolam in a 2:1 fashion under double-blind conditions and underwent depression symptom assessments at 24, 48, 72 h, and 7 days post treatment using the Montgomery–Asberg Depression Rating Scale (MADRS). Post-treatment neurocognitive assessment was conducted once at 7 days. Neurocognitive performance improved following the treatment regardless of treatment condition. There was no differential effect of treatment on neurocognitive performance and no association with antidepressant response. Slower processing speed at baseline uniquely predicted greater improvement in depression at 24 h following ketamine (t=2.3, p=0.027), while controlling for age, depression severity, and performance on other neurocognitive domains. In the current study, we found that ketamine was devoid of adverse neurocognitive effects at 7 days post treatment and that slower baseline processing speed was associated with greater antidepressant response. Future studies are required to further define the neurocognitive profile of ketamine in clinical samples and to identify clinically useful response moderators. 相似文献
64.
Nair Aswin M. Mathew John Goel Ruchika Chebbi Pramod Mathew Ashish Jacob Arvind G. Yadav Bijesh Rebekah Grace Prakash John A. J. Danda Debashish 《Clinical rheumatology》2021,40(7):2805-2819
Clinical Rheumatology - Consensus on treatment of idiopathic inflammatory myositis (IIM), particularly with regard to flares and interstitial lung disease (ILD), does not exist. We studied the... 相似文献
65.
66.
67.
Alvani D. Santos Puthenpurakal K. Mathew Ahmad Hilal Wayne A. Wallace 《The American journal of medicine》1981,71(5):746-750
To test the hypothesis that orthostatic hypotension could represent an alternative mechanism contributing to the symptoms of mitral valve prolapse, the systolic and diastolic arterial blood pressures were measured in the supine and standing positions in 86 patients with the diagnosis confirmed by echocardiography. Orthostatic hypotension was demonstrated in 12 patients. Ten of them presented with a history of recurrent lightheadedness, dizziness or syncope and constitute 59 percent of the total number of patients with such symptoms in this series. Although nine of these 10 patients reported transient lightheadedness or dizziness during periods of ambulatory electrocardiographic recording, in only one were the symptoms chronologically related to cardiac arrhythmias. On the other hand, eight of them described lightheadedness and two experienced near-syncope during the postural test in association with the orthostatic drop in blood pressure. Improvement in symptoms and correction of the orthostatic hypotension were demonstrated in seven patients after beta-adrenergic blockade with propranolol. Before therapy, the mean systolic blood pressure dropped from 114 ± 3 mm Hg in the supine position to 78 ± 1 mm Hg upon standing (p < 0.001). In repeated postural tests performed after four weeks of treatment, the systolic blood pressure changed from 120 ± 3 mm Hg supine to 115 ± 1 mm Hg upon standing (p > 0.01).We conclude that orthostatic hypotension is a commonly unrecognized mechanism responsible for some of the symptoms of mitral valve prolapse, particularly in patients affected by recurrent lightheadedness, dizziness or syncope. 相似文献
68.
69.
70.
Long-term survival of a patient with left ventricular free wall rupture without surgical repair 总被引:2,自引:0,他引:2
This report describes the case of a patient who developed postinfarction left ventricular free wall rupture and cardiac tamponade. He was managed conservatively, made a successful recovery, and is alive and asymptomatic 10 months after the index episode. Only 17 cases in which the patients survived subacute rupture of the ventricular free wall over the long term without surgical repair have been reported in the literature. 相似文献