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991.
Aytekin FO Tekin K Kabay B Erdem E Guney Y Firat P Sungurtekin U Kaya SO Ozden A 《American journal of surgery》2005,189(2):161-166
BACKGROUND: Mesenteric ischemia-reperfusion (I/R) is a well-known event causing both local and remote organ injuries, including the lungs. Recently, several studies indicated that activated leukocyte-endothelial cell interactions play an important role in the mechanisms of these injuries. As a natural inhibitor of serine proteases, antithrombin was shown previously to attenuate the tissue damage after local I/R in several organ systems. Here, we examined the effects of antithrombin on pulmonary injury after mesenteric I/R. METHODS: Wistar albino rats underwent median laparotomy and were randomized into 3 groups: (1) sham-operated control (n = 12), (2) 60 minutes of mesenteric ischemia and 3 hours of reperfusion (n = 12), and (3) antithrombin-pretreated (250 U/kg) group before the I/R (n = 12). At the end of reperfusion, animals were killed and neutrophil sequestration, myeloperoxidase (MPO) activity, and Evans blue dye extravasation in the lung parenchyma were assessed and compared. RESULTS: There was a statistically significant increase in the quantity of Evans blue dye concentration, leukocyte sequestration, and MPO activity in the I/R group when compared with the control group. The pretreatment of animals with antithrombin significantly decreased the pulmonary injury characterized by increased Evans blue dye extravasation, leukocyte sequestration, and MPO activity. CONCLUSION: The data of the present study suggest that mesenteric ischemia and reperfusion induces pulmonary injury characterized by activated neutrophil sequestration and increased microvascular leakage in the lungs. A significant attenuation of intestinal I/R-related lung injury with the use of antithrombin concentrate warrants further studies to elucidate the potential role of this natural serine protease inhibitor in clinical settings. 相似文献
992.
993.
994.
Kazakov DV Suster S LeBoit PE Calonje E Bisceglia M Kutzner H Rütten A Mentzel T Schaller J Zelger B Baltaci M Leivo I Rose C Fukunaga M Simpson RH Yang Y Carlson JA Cavazza A Hes O Mukensnabl P Vanecek T Fidalgo A Pizinger K Michal M 《The American journal of surgical pathology》2005,29(6):764-782
We present the largest series of mucinous carcinoma involving the skin, describing the histopathologic, immunohistochemical, electron microscopic, and cytogenetic findings. Our aim was fully to characterize the clinicopathologic spectrum and compare it with that seen in the breast. In addition, we wished to reevaluate the differential diagnostic criteria for distinguishing primary mucinous carcinomas from histologically similar neoplasms involving the skin secondarily, and study some aspects of their pathogenesis. We demonstrate that primary cutaneous mucinous carcinomas span a morphologic spectrum compatible to their mammary counterparts. Both pure and mixed types can be delineated morphologically, and some lesions have mucocele-like configurations. Most lesions seem to originate from in situ lesions that may represent, using mammary pathology terminology, ductal hyperplasia, atypical ductal hyperplasia, or ductal carcinoma in situ or a combination of the three. Inverse cell polarity appears to facilitate the progression of the changes similar to lesions in the breast. The presence of an in situ component defines the neoplasm as primary cutaneous, but its absence does not exclude the diagnosis; although for such neoplasms, full clinical assessment is essential. Mammary mucinous carcinoma involving the skin: all patients presented with lesions on chest wall, breast, axilla, and these locations can serve as clue to the breast origin. Microscopically, cutaneous lesions were of both pure and mixed type, and this correlated with the primary in the breast. Dirty necrosis was a constant histologic finding in intestine mucinous carcinomas involving the skin, and this feature may serve as a clue to an intestinal origin. 相似文献
995.
Sönmez A Bişkin N Bayramiçli M Numanoğlu A 《Annals of plastic surgery》2005,54(2):172-5; discussion 176-7
Surgery is a serious stressor and a cause of anxiety for the patients. Reconstructive surgery patients are mostly operated on because of certain functional impairment or disability; on the contrary, cosmetic surgery patients do not have any physical impairment and they are operated on because of mostly psychologic reasons. The aim of this study was to compare the anxiety levels in the reconstructive surgery patients and cosmetic surgery patients preoperatively. Thirty-two patients in the reconstructive surgery group and 30 patients in the cosmetic surgery group were included in the study. State Trait Anxiety Inventory was used to measure the anxiety levels in these 2 groups preoperatively. The 2 groups were similar in characteristics such as age, gender distribution, number of previous operations, and trait anxiety scores. Mean state anxiety scores obtained for the reconstructive surgery group was 38.0 +/- 8.7, while it was 44.2 +/- 10.79 for the cosmetic surgery group (t test, degrees of freedom = 60, P = 0.015). This study reveals that preoperative anxiety levels in the cosmetic surgery patients are higher than those of the reconstructive surgery patients. Therefore, adequate preoperative preparation for cosmetic surgery should include attempts to cope with anxiety. Anxiolytics may be used more liberally and professional psychologic assistance may be required. 相似文献
996.
997.
The aim of this study was to determine the effect of a mechanical bowel preparation on postoperative surgical wound infections
in patients treated with identical antimicrobial prophylaxis undergoing wide excision and primary closure for chronic pilonidal
sinus disease. Patients more than 18 years old were included in the study. All patients had intravenous antimicrobial prophylaxis
at the time of anesthesia induction. In a prospective, randomized setting, patients were allocated to either the bowel preparation
group or the no-bowel-preparation group. Mechanical bowel preparation was performed using an oral sodium phosphate solution.
On the morning of the procedure a rectal enema was performed with the phosphate solution. The primary outcome measure was
the rate of wound infection, but all postoperative complications and recurrences were recorded. All patients were actively
observed for 1 year after discharge. The overall infection rate for the entire study population was 12.8% (13/101) including
14.3% (7/49) of those who had had the bowel preparation and 11.5% (6/52) of those with no bowel preparation. There was no
statistically significant difference between groups (P = 0.680). The mean rate of recurrence for all 101 patients was 4.9% (5/101) at 19.2 months (range 12–32 months) of follow-up.
The recurrence rate was 6.1% (3/49) in the bowel preparation group and 3.8% (2/52) in the no-bowel-preparation group (P = 1.000). Although the number of patients is small in this study, our results showed that the mechanical bowel preparation
does not cause a decrease in the rate of surgical wound infections after excision and primary closure in patients with chronic
pilonidal sinus disease. 相似文献
998.
Summary
Background
To investigate
dietary habits and evaluate
these with regard to cardiovascular
risk status in Turkish adolescents
aged 12–19 years.
Methods
A total
of 300 adolescents, 135 males and
165 females aged between 12 and
19, were included in the study. Dietary
intake was determined by using
3–day food records (including 1
weekend day). Adolescents smoking
habits and familial chronic diseases
were recorded. The values obtained
for energy and nutrient
intakes were compared with RDA
and DRI and recommendations
given by AHA.
Results
The mean
energy intakes of male and female
subjects were 1964 ± 723 kcal and
1804 ± 486 kcal respectively. According
to NHANES III, age–standardized (CDC: Centers for Disease
Control and Prevention) prevalence
of overweight indicated that
20.7% among male and 17.5%
among female adolescents were at
risk for becoming overweight. The
prevalence of premature CHD family
history was found to be 9.6%
for males and 11.5 % for females.
The prevalence of current smoking
was found to be 22.2 % for males
and 18.2 % for females. In addition,
29.6% of the males and 37.6% of
the females were physically inactive
(p < 0.05); however, male adolescents
(48.2%) were significantly
more likely than female adolescents
(52.1 %) to report sufficient
moderate physical activity
(p < 0.05). The dietary fiber intake
was slightly below the recommended
intake of 10 g per 1000
kcal. Compared to the AHA averages,
these adolescents had significantly
higher intake of total fat, saturated
fat, sodium and dietary
cholesterol and lower intake of
polyunsaturated fat, monounsaturated
fat and dietary fiber. The
Turkish adolescents also had
higher amounts of energy from fat.
The mean percentage of energy
from fat was 34.2 ± 6% TE for
males and 35.2 ± 6.8 % TE for females;
saturated fat was
11.8 ± 6.8 % TE for males and
12.1 ± 8.9 for females. The intake of
fat and saturated fat was higher
than the AHA recommendations.
The polyunsaturated to saturated
fat ratio was 0.4 ± 0.2 and reflected
a high saturated fat (12.0 ± 7.7%
TE) and low polyunsaturated fat
(5.5 ± 3.9 % TE) diet. In addition,
the percentage of adolescents who
did not meet 66% of RDA for vitamin
E, B6, and folates and the recommendation
for RDA dietary
fiber is presented. Approximately,
80% of adolescents failed to meet
the dietary recommendation of the
AHA for polyunsaturated fatty
acids, and about 26.7% reported a
cholesterol intake higher than
100 mg/1000 kcal.
Conclusion
It can
be said that fiber, total fat, saturated
fatty acid, cholesterol and
sodium intake of Turkish adolescents
are found to be high; however,
their vitamin E, vitamin B6
and folate intake are found to be
low compared to AHA recommendations.
Turkish adolescents fruit
and vegetable intake are also found
to be low. 相似文献
999.
1000.
AIM: A high rate of seropositivity for antibodies against Helicobacter pylori has been found in many extra-gastrointestinal diseases. In addition, it has been reported that the risk of chronic bronchitis may be increased in subjects infected with H. pylori. This study was designed to determine the H. pylori seroprevalence in patients with and without chronic bronchitis. MATERIALS AND METHODS: This study enrolled 68 patients with chronic bronchitis (40 men and 28 women, aged 50.5+/-16.2 years (mean+/-standard deviation) and 95 control subjects (60 men and 35 women, aged 51.8+/-15.9 years) matched for age and sex. An enzyme-linked immunosorbent assay immunoglobulin (Ig) G test for H. pylori diagnosis was performed on all enrolled subjects (those with chronic bronchitis and controls). RESULTS: Forty-five of 68 patients with chronic bronchitis (66.1%) and 48 of 95 subjects in the control group (57.7%) tested positive for H. pylori (P=0.008). Rates of H. pylori infection are higher in patients with chronic bronchitis than in the control group. CONCLUSION: The main conclusion of this study is that H. pylori infection is associated with an increased prevalence chronic bronchitis. Further studies should be planned to understand the potential pathogenetic mechanisms that might underlie this association. 相似文献