Laboratory tumor lysis syndrome complicating LBH589 therapy in a patient with acute myeloid leukaemia

LBH589 is a novel cinnamic hydroxamic acid analog (HAA) pan-histone deacetylase inhibitor (HDACi) currently in early phase clinical development.     

Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis

OBJECTIVES: Use three-dimensional (3D) facial laser scanned images from children with fetal alcohol syndrome (FAS) and controls to develop an automated diagnosis technique that can reliably and accurately identify individuals prenatally exposed to alcohol. METHODS: A detailed dysmorphology evaluation, history of prenatal alcohol exposure, and 3D facial laser scans were obtained from 149 individuals (86 FAS; 63 Control) recruited from two study sites (Cape Town, South Africa and Helsinki, Finland). Computer graphics, machine learning, and pattern recognition techniques were used to automatically identify a set of facial features that best discriminated individuals with FAS from controls in each sample. RESULTS: An automated feature detection and analysis technique was developed and applied to the two study populations. A unique set of facial regions and features were identified for each population that accurately discriminated FAS and control faces without any human intervention. CONCLUSION: Our results demonstrate that computer algorithms can be used to automatically detect facial features that can discriminate FAS and control faces.     

Automatic axis generation for virtual bronchoscopic assessment of major airway obstructions.

Virtual bronchoscopy (VB) has emerged as a paradigm for more effective 3D CT image evaluation. Systematic evaluation of a 3D CT chest image using VB techniques, however, requires precomputed guidance data. This guidance data takes the form of central axes, or centerlines, through the major airways. We propose an axes-generation algorithm for VB assessment of 3D CT chest images. For a typical high-resolution 3D CT chest image, the algorithm produces a series of airway-tree axes, corresponding airway cross-sectional area measurements, and a segmented airway tree in a few minutes on a standard PC. Results for phantom and human airway-obstruction cases demonstrate the efficacy of the algorithm. Also, the algorithm is demonstrated in the context of VB-based 3D CT assessment.     

UNUSUAL BILIARY FISTULA

Agenesis of gall bladder is a clinical rarity, as most of the diagnoses are made at autopsy. Preoperative diagnosis of this anomaly is fraught with follies. External biliary fistulae are usually result of complications of trauma or biliary surgery. Internal fistulae on the other hand may result from erosion of wall by a stone, cancerous growth or peptic ulcer. Sites of opening of internal fistulae are stomach, duodenum, jejunum, ileum or colon. These should be suspected if gas shadows are seen in biliary tree.KEY WORDS: Biliary calculi, Choledochogastric fistula, Gall bladder agenesis, Pneumobilia     

The use of CPR in New Zealand: is it always lawful?

Since its development in the early 1960s, the use of CPR in the hospital setting has undergone intriguing changes. After initially being used very selectively, at the discretion of the doctor, the use of CPR rapidly expanded to the point that it was promptly begun on all patients having a cardiac arrest in hospital, regardless of the underlying illness. However, it soon became evident that the use of CPR on all patients created problems. In response to this, DNR orders were developed. The standard policy of New Zealand hospitals is now for CPR to be attempted on all patients having a cardiac arrest unless a DNR order is in place. We argue that this approach is not consistent with New Zealand law and that current policies should be amended to bring them into line with the Code of Rights and New Zealand law generally.     

Effect of implantation site and growth of hepatocellular carcinoma on apparent diffusion coefficient of water and sodium MRI

Hepatocellular carcinoma (HCC) and liver metastases are an increasing problem worldwide. Non-invasive methods for the early detection of HCC and understanding of the tumor growth mechanisms are highly desirable. Both the diffusion-weighted (1)H (DWI) and (23)Na MRI reflect alterations in tissue compartment volumes in tumors, as well as physiological and metabolic transformation in cells. Effects of untreated growth on apparent diffusion coefficient of water (ADC), single quantum (SQ) and triple quantum-filtered (TQF) (23)Na MRI were compared in intrahepatically and subcutaneously implanted HCCs in rats. Animals were examined weekly for 4 weeks after injection of N1S1 cells. ADC of intrahepatic HCC was 1.5-times higher compared to the nearby liver tissue, and with growth, the ADC did not increase. ADC of subcutaneous HCC was lower compared to intrahepatic HCC and it increased with growth. Untreated growth of both intrahepatic and subcutaneous HCCs was associated with an increase in SQ and TQF (23)Na signal intensity suggesting an increase in tissue Na(+) and intracellular Na(+) (Na(+)(i)), respectively, most likely due to an increase in relative extracellular space and Na(+)(i) concentration as a result of changes in tissue structure and cellular metabolism. Thus, SQ and TQF (23)Na MRI may be complementary to diffusion imaging in areas susceptible to motion for characterizing hepatic tumors and for other applications, such as, predicting and monitoring therapy response.     

An evaluation of social skills in children with and without prenatal alcohol exposure

Background The goal of this study was to examine social skills deficits among children with and without prenatal alcohol exposure (PAE) who were both referred to a respite programme. Methods Thirty‐seven children with PAE and 23 non‐exposed children (aged 3 to 8 years) were evaluated on the Social Skills Rating System (SSRS) by their caregivers and respite workers. Results As compared with the non‐exposed children, those with PAE showed more deficits on caregiver ratings of responsibility, hyperactivity, internalizing problems and overall social skills, as well as respite worker ratings of hyperactivity. The social skills among the PAE group were not related to home placement variables. Among both groups, caregivers rated social skills lower than respite workers, and among the PAE group, girls tended to display more social skills deficits than boys. Conclusions The SSRS is useful in identifying unique social skills deficits among children with PAE.